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  • T69091CBP501；化合物 CBP501CBP501

    CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle.

    价 格：￥电议型 号：T69091产 地：中国大陆

  • T69052P552-02 free base；化合物 P552-02 free baseP552-02 free base

    P552-02, also known as KM-003, PS 552-02, or 552-02, is a sodium channel blocker potentially for the treatment of cystic fibrosis.

    价 格：￥电议型 号：T69052产 地：中国大陆

  • T684145-ClTEP；化合物 5-ClTEP5-ClTEP

    5-ClTEP is a HIV-1 integrase inhibitor.

    价 格：￥电议型 号：T68414产 地：中国大陆

  • T67972LAmp579 TFA；Amp579三氟乙酸盐Amp579 TFA(213453-89-5 Free base)；Amp579 TFA(213453-89-5 Free base)

    Amp579 TFA is a novel adenosine A1/A2a receptor agonist that induces acute and delayed preconditioning against myocardial shock in vivo.

    价 格：￥电议型 号：T67972L产 地：中国大陆

  • T67858STIMA-1；2-乙烯基-3H-4-喹唑啉酮2-Vinylquinazolin-4-ol|||p53 Activator VII；2-Vinylquinazolin-4-ol|||p53 Activ

    STIMA-1 (2-Vinylquinazolin-4-ol), an active compound, can restore the activity of p63. STIMA-1 can stimulate the proliferation and differentiation of keratinocytes.

    价 格：￥电议型 号：T67858产 地：中国大陆

  • T67698p53-Mdm2 inhibitor 4；化合物 p53-Mdm2 inhibitor 4p53-Mdm2 inhibitor 4

    p53-Mdm2 inhibitor 4 inhibits the p53-MDM2 protein-protein interaction.

    价 格：￥电议型 号：T67698产 地：中国大陆

  • T64182HP590；化合物 HP590HP590

    HP590 is a novel, potent, orally active STAT3 inhibitor (STAT3 luciferase activity: IC50=27.8 nM; ATP inhibition: IC50=24.7 nM). HP590 has an anti-proliferative effect on gastric cancer cells and induces apoptosis.

    价 格：￥电议型 号：T64182产 地：中国大陆

  • T64154CYP51/HDAC-IN-1；化合物 CYP51/HDAC-IN-1CYP51/HDAC-IN-1

    CYP51/HDAC-IN-1 is an orally active, potent, dual CYP51/HDAC inhibitor that inhibits important virulence factors and down-regulates the expression of associated drug resistance genes.CYP51/HDAC-IN-1 has shown effective therapeutic effects in both Candidiasis tropicalis and Cryptococcal meningitis.

    价 格：￥电议型 号：T64154产 地：中国大陆

  • T64079Mutant p53 modulator-1；化合物 Mutant p53 modulator-1Mutant p53 modulator-1

    Mutant p53 modulator-1 is a mutant p53 modulator. mutant p53 modulator-1 is able to hinder the progression of cancers containing p53 mutations.

    价 格：￥电议型 号：T64079产 地：中国大陆

  • T63748rel-MDM2/4-p53-IN-2；化合物 rel-MDM2/4-p53-IN-2rel-MDM2/4-p53-IN-2

    rel-MDM2/4-p53-IN-2 (2q) is a potent dual MDM2/MDM4 inhibitor and p53 activator that acts on both the MDM2-p53 complex (IC50: 70.7 nM) and the MDM4-p53 complex (IC50: 81.4 nM). rel-MDM2/4-p53-IN-2 is capable of regulating cell cycle, induce apoptosis, and exhibit anti-cancer effects.

    价 格：￥电议型 号：T63748产 地：中国大陆

  • T63438rel-MDM2/4-p53-IN-3；化合物 rel-MDM2/4-p53-IN-3rel-MDM2/4-p53-IN-3

    rel-MDM2/4-p53-IN-3 is an MDM2/4-p53 protein-protein interaction (PPI) inhibitor that acts on MDM2-p53 and MDM4-p53 with IC50 values of 18.5 nM and 14.8 nM, respectively. rel-MDM2/4-p53-IN-3 can be used to study cancers, such as colon cancer.

    价 格：￥电议型 号：T63438产 地：中国大陆

  • T63373S100A2-p53-IN-1；化合物 S100A2-p53-IN-1S100A2-p53-IN-1

    S100A2-p53-IN-1 (compound 51), an inhibitor of S100A2-p53 interactions, targets S100A2, a Ca 2+ binding protein involved in cell signaling and commonly upregulated in pancreatic cancer. This compound effectively inhibits the growth of the MiaPaCa-2 pancreatic cancer cell line, showing a growth inhibition (GI 50) range of 1.2-3.4 μM [1].

    价 格：￥电议型 号：T63373产 地：中国大陆

  • T63202AP5 sodium；化合物 AP5 sodiumAP5 sodium

    AP5 sodium is a selective, potent, orally active GPR40 receptor agonist that exhibits positive allosteric modulation of endogenous ligands (AgoPAM). sodium exhibits potential for the study of type II diabetes.

    价 格：￥电议型 号：T63202产 地：中国大陆

  • T62657SHP504；化合物 SHP504SHP504

    SHP504 is an inhibitor of SHP2 phosphatase and acts on SHP21-525 (IC50: 21 μM).

    价 格：￥电议型 号：T62657产 地：中国大陆

  • T62041XP5；化合物 XP5XP5

    XP5 is a potent, orally active HDAC6 inhibitor (IC50= 31 nM). XP5 inhibits the proliferation of various cancer cell lines including the HDACi-resistant YCC3/7 gastric cancer cells (IC50=0.16-2.31 μM).

    价 格：￥电议型 号：T62041产 地：中国大陆

  • T61369p53 Activator 2；化合物 p53 Activator 2p53 Activator 2

    p53 Activator 2 (compound 10ah) intercalates into DNA, causing significant DNA double-strand breaks and upregulates the expression of p53, p-p53, CDK4, and p21, leading to cell cycle arrest at the G2/M phase. It induces apoptosis, significantly reduces the expression of anti-apoptosis proteins Bcl-2, Bcl-xL, and cyclin B1 levels, and exhibits anti-proliferative activity against MGC-803 cells with an IC50 of 1.73 μM. Furthermore, p53 Activator 2 demonstrates potent anticancer effectiveness in MGC

    价 格：￥电议型 号：T61369产 地：中国大陆

  • T60839SLMP53-1；化合物 SLMP53-1SLMP53-1

    SLMP53-1 is a p53 activator with anti-tumor activity, inhibits wt and mutp53, activates reprogramming of glucose metabolism in xenografted human tumor tissues, and interferes with angiogenesis and migration. SLMP53-1 inhibits tumor cell growth and can be used to study human rectal cancer.

    价 格：￥电议型 号：T60839产 地：中国大陆

  • T60130USP5-IN-1；化合物USP5-IN-1USP5-IN-1

    USP5-IN-1 (compound 64) is a potent deubiquitinase USP5 inhibitor, which binds to the USP5 ZnF-UBD with a KD of 2.8 μM and is selective over nine proteins containing structurally similar ZnF-UBD domains. USP5-IN-1 inhibits the USP5 catalytic cleavage of a di-ubiquitin substrate [1].

    价 格：￥电议型 号：T60130产 地：中国大陆

  • T5514Epibrassinolide表油菜素内酯24-Epibrassinolide|||B1105|||表油菜素内酯|||BP55

    Epibrassinolide (BP55) (EBR) is a biologically active compound of the brassinosteroids, is a natural brassinosteroid (BR) derivative, is a plant regulator with a similar structure to mammalian steroids.

    价 格：￥电议型 号：T5514产 地：中国大陆

  • T5473ASP5878；化合物ASP-5878ASP-5878；ASP-5878

    ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.

    价 格：￥电议型 号：T5473产 地：中国大陆

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