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T19244CNP-AFU;化合物CNP-AFU2-Chloro-4-nitrophenyl α-L-fucopyranoside;2-Chloro-4-nitrophenyl α-L-fucopyranosid
CNP-AFU (2-Chloro-4-nitrophenyl α-L-fucopyranoside) is the substrate of alpha-L-fucosidase.
价 格:¥电议型 号:T19244产 地:中国大陆
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T1924LDN-57444;化合物LDN-57444LDN57444;LDN57444
LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .
价 格:¥电议型 号:T1924产 地:中国大陆
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T1898RKI-1447;化合物RKI-1447RKI1447;RKI1447
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
价 格:¥电议型 号:T1898产 地:中国大陆
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T18944CY3-YNE化合物 T18944Sulfo-Cyanine3-alkyne
CY3-YNE (Sulfo-Cyanine3-alkyne) is a dye for the labeling of oligonucleotides/DNA, soluble proteins, and peptides.
价 格:¥电议型 号:T18944产 地:中国大陆
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T18844Thiol-PEG9-alcohol;化合物 T18844HS-PEG9-OH;HS-PEG9-OH
Thiol-PEG9-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T18844产 地:中国大陆
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T1881AR-A014418;化合物AR-A014418AR 0133418|||GSK-3beta Inhibitor VIII|||AR 014418|||GSK 3β inhibitor VIII;AR
AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.
价 格:¥电议型 号:T1881产 地:中国大陆
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T18744t-Boc-Aminooxy-PEG7-bromide;化合物 T18744t-Boc-Aminooxy-PEG7-bromide
t-Boc-Aminooxy-PEG7-bromide is a polyethylene glycol (PEG)-based bifunctional linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
价 格:¥电议型 号:T18744产 地:中国大陆
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T18691SNIPER(ABL)-044;化合物 T18691SNIPER(ABL)-044
SNIPER(ABL)-044, a compound that links HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, achieving a DC50 value of 10 μM[1].
价 格:¥电议型 号:T18691产 地:中国大陆
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T18644PTAD-PEG4-N3;化合物 T18644PTAD-PEG4-N3
PTAD-PEG4-N3 is a cleavable four-unit polyethylene glycol (PEG) antibody-drug conjugate (ADC) linker, utilized in ADC synthesis[1].
价 格:¥电议型 号:T18644产 地:中国大陆
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T18544Phthalimide-PEG4-PDM-OTBS;化合物 T18544Phthalimide-PEG4-PDM-OTBS
Phthalimide-PEG4-PDM-OTBS is a PROTAC linker comprised of polyethylene glycols (PEGs). This compound is utilized in the synthesis of a range of PROTACs, which consists of two distinct ligands connected by a linker. One ligand binds to an E3 ubiquitin ligase, while the other ligand binds to the target protein. By leveraging the intracellular ubiquitin-proteasome system, PROTACs selectively degrade target proteins[1].
价 格:¥电议型 号:T18544产 地:中国大陆
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T18443N-Me-N-bis(PEG4-C2-Boc);化合物 T18443N-Me-N-bis(PEG4-C2-Boc)
N-Me-N-bis(PEG4-C2-Boc) is a PROTAC linker utilizing alkyl and ether functionalities, which is instrumental in PROTAC synthesis. [1]
价 格:¥电议型 号:T18443产 地:中国大陆
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T18442N-Me-N-bis(PEG4-acid);化合物 T18442N-Me-N-bis(PEG4-acid)
N-Me-N-bis(PEG4-acid) is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T18442产 地:中国大陆
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T18441N-Me-N-bis-PEG3;化合物 T18441N-Me-N-bis-PEG3
N-Me-N-bis-PEG3 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T18441产 地:中国大陆
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T18440N-(Mal-PEG6)-N-bis(PEG7-TCO);化合物 T18440N-(Mal-PEG6)-N-bis(PEG7-TCO)
N-(Mal-PEG6)-N-bis(PEG7-TCO) is a polyethylene glycol (PEG)-based PROTAC linker employed for PROTAC synthesis[1].
价 格:¥电议型 号:T18440产 地:中国大陆
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T1844KPT330,(E)-;化合物KPT330,(E)-(E)-RN|||KPT-330|||KPT330|||KPT 330;(E)-RN|||KPT-330|||KPT330|||KPT 330
(E)-RN (KPT 330) is a CRM1-selective inhibitor of nuclear export. It inhibits protein trafficking from the nucleus and induces cell cycle arrest and apoptosis in mesothelioma cells.
价 格:¥电议型 号:T1844产 地:中国大陆
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T18344Methyltetrazine-PEG24-Boc;化合物 T18344Methyltetrazine-PEG24-Boc
Methyltetrazine-PEG24-Boc is a polyethylene glycol (PEG) derivative utilized as a linker compound in PROTAC synthesis. This PEG-based linker enables the construction of PROTACs[1].
价 格:¥电议型 号:T18344产 地:中国大陆
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T1820CK-636;化合物CK-636CK-0944636|||CK 636;CK-0944636|||CK 636
CK-636 (CK-0944636), an Arp2/3 complex inhibitor, can inhibit actin polymerization induced by the human (IC50: 4 μM), fission yeast (IC50: 24 μM) and bovine (IC50: 32 μM) Arp2/3 complex, respectively.
价 格:¥电议型 号:T1820产 地:中国大陆
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T18144m-PEG12-Thiol;化合物 T18144m-PEG12-Thiol
m-PEG12-Thiol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T18144产 地:中国大陆
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T18053Ipatasertib-NH2;化合物 T18053RG7440-NH2|||GDC-0068-NH2;RG7440-NH2|||GDC-0068-NH2
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 to degrade AKT[1].
价 格:¥电议型 号:T18053产 地:中国大陆
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T18044Hydroxy-PEG4-C2-nitrile;化合物 T18044Hydroxy-PEG4-C2-nitrile
Hydroxy-PEG4-C2-nitrile is a polyethylene glycol (PEG) based linker commonly employed in the synthesis of Proteolysis Targeting Chimeras (PROTACs)[1].
价 格:¥电议型 号:T18044产 地:中国大陆