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T63027Antibacterial agent 66;化合物 Antibacterial agent 66Antibacterial agent 66
Antibacterial agent 66 (Compound 6q) is a trifluoromethylpyridine 1,3,4-oxadiazole derivative active against Xanthomonas oryzae pv. oryzae (Xoo) (EC50: 7.2 μg/mL).
价 格:¥电议型 号:T63027产 地:中国大陆
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T63025Antitubercular agent-26;化合物 Antitubercular agent-26Antitubercular agent-26
Antitubercular agent-26 (Compound 32) is an orally active antitubercular agent that acts on M. tuberculosisH37Rv cells (IC50: 0.50 μM extracellularly and 0.51 μM intracellularly). 26 has good metabolic stability, low risk of cardiotoxicity and no genotoxicity.
价 格:¥电议型 号:T63025产 地:中国大陆
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T62935Anticancer agent 26;化合物 Anticancer agent 26Anticancer agent 26
Anticancer agent 26 is a promising candidate for cancer therapy and deserves further development.
价 格:¥电议型 号:T62935产 地:中国大陆
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T62710Antitrypanosomal agent 6;化合物 Antitrypanosomal agent 6Antitrypanosomal agent 6
Antitrypanosomal agent 6 (compound 18a) is a potent antitrypanosomal agent showing good ADME properties. Antitrypanosomal agent 6 is more than twice as active as Nifurtimox against Trypanosoma brucei (T. brucei) with an IC50 of 0.47 μM. Antitrypanosomal agent 6 has a strong interaction with DNA and selectively binds AT-rich DNA.
价 格:¥电议型 号:T62710产 地:中国大陆
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T62613ALK5-IN-26;化合物 ALK5-IN-26ALK5-IN-26
ALK5-IN-26 (EX-22) is an ALK (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 (IC50 ≤ 1 nM).
价 格:¥电议型 号:T62613产 地:中国大陆
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T62574Antileishmanial agent-6;化合物 Antileishmanial agent-6Antileishmanial agent-6
Antileishmanial agent-6 is a potent anti-leishmanial agent with anti-leishmanial activity (IC50: 0.54 μM) and cytotoxicity (IC50: 10.2 μM) against Leishmania donovani and L-6.
价 格:¥电议型 号:T62574产 地:中国大陆
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T62360AChE-IN-26;化合物AChE-IN-26AChE-IN-26
AChE-IN-26 (compound 4a) is an AChE (acetylcholinesterase) inhibitor (IC50: 0.42 μM).
价 格:¥电议型 号:T62360产 地:中国大陆
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T6232Vilazodone Hydrochloride;盐酸维拉佐酮SB659746A|||EMD 68843|||Vilazodone HCl;盐酸维拉佐酮|||SB659746A|||EMD 68843
Vilazodone Hydrochloride (EMD 68843) , a partial agonist of 5-HT1A receptors and specific serotonin reuptake inhibitor (SSRI), is utilized in treating of the major depressive disorder.
价 格:¥电议型 号:T6232产 地:中国大陆
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T62278Anticancer agent 36;化合物 Anticancer agent 36Anticancer agent 36
Anticancer agent 36 (compound 11) is a potent anti-microbial and anti-cancer agent, a sulfonylurea derivative. anticancer agent 36 inhibits the microbial growth of Bacillus mycoides, Escherichia coli and Candida albicans (MIC: 0.156 - 0.039 mg/mL). Anticancer agent 36 inhibited the growth of A549 cells (IC50: 19.7 μg/mL), PC3 cells (IC50: 11.9 μg/mL).
价 格:¥电议型 号:T62278产 地:中国大陆
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T62160AS-136A;化合物 AS-136AAS-136A
AS-136A is an orally active, non-nucleoside inhibitor of measles virus RNA-dependent RNA polymerase (RdRp) that acts against measles virus (IC50: 2 μM).
价 格:¥电议型 号:T62160产 地:中国大陆
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T62063Antibacterial agent 76;化合物 Antibacterial agent 76Antibacterial agent 76
Antibacterial agent 76 (compound 9) is a potent antibacterial agent.
价 格:¥电议型 号:T62063产 地:中国大陆
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T62052AMPK activator 6;化合物 AMPK activator 6AMPK activator 6
AMPK activator 6 (Compound GC) activates the AMPK pathway and reduces lipid content in HepG2 and 3T3-L1 cells. AMPK activator 6 significantly suppresses the increase of total cholesterol (TC), low-density lipoprotein-C (LDL-C), triglyceride (TG), and other biochemical indices in blood serum. AMPK activator 6 has research value in non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome .
价 格:¥电议型 号:T62052产 地:中国大陆
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T61996Antiproliferative agent-6;化合物 Antiproliferative agent-6Antiproliferative agent-6
Antiproliferative agent-6 (compound 8a) is a potent antitumor compound. Antiproliferative agent-6 shows antiproliferative activity. Antiproliferative agent-6 inhibits cancer cell lines HCT116, MCF-7, H460 and non-tumor aneuploid immortal keratinocyte HaCaT cells with GI 50 s of 0.5 μM, 2 μM, 0.7 μM and 3.5 μM, respectively.
价 格:¥电议型 号:T61996产 地:中国大陆
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T61868Antitumor agent-66;化合物 Antitumor agent-66Antitumor agent-66
Antitumor agent-66 (Compound 4) is a derivative of (-)-cleistenolide, showcasing potential as a research tool for cancer diseases [1].
价 格:¥电议型 号:T61868产 地:中国大陆
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T61849AM8936;化合物 AM8936AM8936
AM8936 is a well-balanced and highly potent agonist for the cannabinoid receptor type-1 (CB1) in functional assays, with EC50 values of 8.6 nM and 1.4 nM for the rat CB1 (rCB1) and human CB1 (hCB1) receptors, respectively. It demonstrates a strong affinity for the rat CB1 receptor, exhibiting a K i value of 0.55 nM. In vivo studies have confirmed that AM8936 is a powerful and effective agonist for the CB1 receptor. Due to its therapeutic potential, AM8936 is particularly valuable for research fo
价 格:¥电议型 号:T61849产 地:中国大陆
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T61810Anti-inflammatory agent 16;化合物 Anti-inflammatory agent 16Anti-inflammatory agent 16
Anti-inflammatory agent 16 (compound 14) is a highly effective peptidomimetic with potent anti-inflammatory properties. It effectively reduces the expression levels of TNFα, NO, CD40, and CD86 [1].
价 格:¥电议型 号:T61810产 地:中国大陆
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T61790AKR1C3-IN-6;化合物 AKR1C3-IN-6AKR1C3-IN-6
AKR1C3-IN-6 (Compound 1) is a powerful and specific inhibitor of AKR1C3, with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. It demonstrates significant antitumor activity [1].
价 格:¥电议型 号:T61790产 地:中国大陆
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T61673Anticancer agent 56;化合物 Anticancer agent 56Anticancer agent 56
Anticancer agent 56 (compound 4d) is a powerful anti-cancer compound with favorable drug-like properties. It shows significant anticancer activity against multiple cancer cell lines, with an IC50 value of less than 3 μM. Anticancer agent 56 exerts its effects by causing cell cycle arrest at the G2/M phase and activating the mitochondrial apoptosis pathway. Mechanistically, it induces the accumulation of reactive oxygen species (ROS), upregulates BAX, downregulates Bcl-2, and triggers the activat
价 格:¥电议型 号:T61673产 地:中国大陆
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T61624Antibacterial agent 106;化合物 Antibacterial agent 106Antibacterial agent 106
Antibacterial agent 106 (compound 8) is a highly effective orally active antibacterial compound with antibiofilm activity. It demonstrates potent antibacterial effects against multi-drug resistant (MDR)-Gram-positive pathogens, including the eradication of 99.7% of intracellular methicillin-resistant S. aureus (MRSA) harbored within macrophages [1].
价 格:¥电议型 号:T61624产 地:中国大陆
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T61555Aldose reductase-IN-6;化合物 Aldose reductase-IN-6Aldose reductase-IN-6
Aldose reductase-IN-6 (Compound 3) is a competitive inhibitor of aldose reductase (AR), possessing an IC50 of 3.164 μM and a Ki of 0.018 μM. Notably, Aldose reductase-IN-6 demonstrates no cytotoxicity toward normal cells [1].
价 格:¥电议型 号:T61555产 地:中国大陆