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T18692SNIPER(ABL)-047；化合物 T18692SNIPER(ABL)-047
SNIPER(ABL)-047, a compound that links HG-7-85-01 (an ABL inhibitor) to MV-1 (an IAP ligand) via a linker, effectively decreases the BCR-ABL protein levels, achieving a DC50 value of 2 μM[1].
价 格：￥电议型 号：T18692产 地：中国大陆
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T18647Pyrene-PEG5-propargyl；化合物 T18647Pyrene-PEG5-propargyl
Pyrene-PEG5-propargyl is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T18647产 地：中国大陆
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T18547(+)-Biotin-PEG10-OH；化合物 T18547(+)-Biotin-PEG10-alcohol；(+)-Biotin-PEG10-alcohol
(+)-Biotin-PEG10-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T18547产 地：中国大陆
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T18479NH-bis(C1-Boc)亚氨基二乙酸二异丁酯亚氨基二乙酸二异丁酯
NH-bis(C1-Boc)is a uncleavable linker. NH-bis can be used for antibody-drug conjugates (ADC).
价 格：￥电议型 号：T18479产 地：中国大陆
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T18478NAMPT inhibitor-linker 2；化合物 T18478NAMPT inhibitor-linker 2
NAMPT inhibitor-linker 2, a drug-linker conjugate for antibody-drug conjugates (ADCs), comprises an NAMPT inhibitor payload and a linker. When combined with an anti-c-Kit monoclonal antibody to form ADC-4, it demonstrates potent efficacy against c-Kit expressing cell lines, including GIST-T1 and NCI-H526, with IC50 values of <7 pM and 40 pM, respectively.
价 格：￥电议型 号：T18478产 地：中国大陆
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T18477NAMPT inhibitor-linker 1；化合物 T18477NAMPT inhibitor-linker 1
NAMPT inhibitor-linker 1, a drug-linker conjugate for ADC, integrates an NAMPT inhibitor (as a payload) with a linker. In the formulation of ADC-3, it pairs with an anti-c-Kit monoclonal antibody, demonstrating strong efficacy against c-Kit expressing cell lines, specifically GIST-T1 and NCI-H526, where it exhibits IC50 values of <3 pM and 9 pM, respectively.
价 格：￥电议型 号：T18477产 地：中国大陆
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T18476N3-Ph-NHS ester琥珀酰亚胺基 4-叠氮基苯甲酸酯琥珀酰亚胺基 4-叠氮基苯甲酸酯
N3-Ph-NHS ester is a noncleavable ADC linker. N3-Ph-NHS ester can be used in the synthesis of antibody-drug conjugates (ADCs).
价 格：￥电议型 号：T18476产 地：中国大陆
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T18475N3-PEG6-Propanehydrazide；化合物 T18475N3-PEG6-Propanehydrazide
N3-PEG6-Propanehydrazide is a polyethylene glycol (PEG) derived linker, specifically designed for use in the synthesis of proteolysis targeting chimeras (PROTACs) [1].
价 格：￥电议型 号：T18475产 地：中国大陆
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T18474N3-PEG5-aldehyde；化合物 T18474N3-PEG5-aldehyde
N3-PEG5-aldehyde is a 5-unit cleavable polyethylene glycol (PEG) linker specifically designed for antibody-drug conjugates (ADCs) synthesis[1].
价 格：￥电议型 号：T18474产 地：中国大陆
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T18473N3-PEG3-vc-PAB-MMAE；化合物 T18473N3PEG3vcPABMMAE|||N3-PEG3-vc-PAB-MMAE|||N-3-PEG3-vc-PAB-MMAE|||N3 PEG3
N3-PEG3-vc-PAB-MMAE, a drug-linker conjugate designed for Antibody-Drug Conjugates (ADC), features the integration of monomethyl auristatin E (MMAE), a tubulin inhibitor, via a 3-unit polyethylene glycol (PEG) linker. This compound demonstrates significant antitumor activity.
价 格：￥电议型 号：T18473产 地：中国大陆
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T18472N3-PEG3-Propanehydrazide；化合物 T18472N3-PEG3-Propanehydrazide
N3-PEG3-Propanehydrazide serves as a PEG-based PROTAC linker, employed for PROTAC synthesis [1].
价 格：￥电议型 号：T18472产 地：中国大陆
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T18471N3-PEG24-Hydrazide；化合物 T18471N3-PEG24-Hydrazide
N3-PEG24-Hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T18471产 地：中国大陆
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T18470N3-PEG16-Hydrazide；化合物 T18470N3-PEG16-Hydrazide
N3-PEG16-Hydrazide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T18470产 地：中国大陆
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T1847Necrostatin-1；化合物Necrostatin-1Nec-1|||Necrostatin 1；Nec-1|||Necrostatin 1
Necrostatin-1 (Nec-1) is a necrotic apoptosis inhibitor and RIP1 inhibitor with specificity. Necrostatin-1 inhibits TNF-α-induced necrotic apoptosis. Necrostatin-1 also inhibits IDO.
价 格：￥电议型 号：T1847产 地：中国大陆
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T18347Methyltetrazine-PEG25-acid；化合物 T18347Methyltetrazine-PEG25-acid
Methyltetrazine-PEG25-acid is a PEG-derived PROTAC linker utilized for the synthesis of PROTACs[1].
价 格：￥电议型 号：T18347产 地：中国大陆
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T18247Mal-C2-Gly3-EDA；化合物 T18247Mal-C2-Gly3-EDA
Mal-C2-Gly3-EDA is a cleavable antibody-drug conjugate (ADC) linker equipped with a Maleimide moiety. It serves the purpose of facilitating the synthesis of ADCs.
价 格：￥电议型 号：T18247产 地：中国大陆
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T1815Dapivirine；达匹维林R147681|||TMC120；R147681|||达匹维林|||TMC120
Dapivirine (R147681) is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor.
价 格：￥电议型 号：T1815产 地：中国大陆
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T18147m-PEG13-NHS ester；化合物 T18147m-PEG13-NHS ester
m-PEG13-NHS ester is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T18147产 地：中国大陆
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T18047Hydroxy-PEG8-CH2-Boc；化合物 T18047HO-PEG8-CH2COOtBu；HO-PEG8-CH2COOtBu
Hydroxy-PEG8-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T18047产 地：中国大陆
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T17947Fmoc-aminooxy-PEG12-acid；化合物 T17947Fmoc-aminooxy-PEG12-acid
Fmoc-aminooxy-PEG12-acid, a PEG-based PROTAC linker, is employed for synthesizing PROTACs[1].
价 格：￥电议型 号：T17947产 地：中国大陆
