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T41231GP 1a;化合物GP 1aGP 1a
GP 1a is a potent agonist of cannabinoid receptor 2 (CB2) (EC50=7.1), as shown in cAMP, GTPγS and β-arrestin recruitment assays. GP 1a is approximately 30-fold more selective for CB2 receptors than CB1 receptors and increases P-ERK1/2 expression in HL-60 cells in vitro. GP 1a is beneficial for skin wound healing. GP 1a inhibits inflammation and fibrogenesis while promoting epithelial re-formation.
价 格:¥电议型 号:T41231产 地:中国大陆
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T41230CB 65;化合物CB 65CB 65
CB 65 is a high affinity and selective CB2 receptor agonist with Ki values of 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.
价 格:¥电议型 号:T41230产 地:中国大陆
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T4123LYN-1604;化合物LYN1604LYN1604;LYN1604
LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
价 格:¥电议型 号:T4123产 地:中国大陆
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T40998S-6123;S-6123S-6123
S-6123 is a highly effective antimicrobial compound classified under the oxazolidinone series, and it acts by selectively inhibiting ribosomal protein synthesis while not affecting DNA or RNA synthesis.
价 格:¥电议型 号:T40998产 地:中国大陆
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T4049Genz-123346 free base;化合物Genz-123346 free baseGenz-123346 free base
Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.
价 格:¥电议型 号:T4049产 地:中国大陆
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T40123BMS-986251;BMS-986251BMS-986251
BMS-986251 is a potent and specific RORγt inverse agonist that exerts its action via oral administration. It shows an EC 50 of 12 nM for RORγt GAL4. In human whole blood assay, BMS-986251 effectively inhibits IL-17 with an EC 50 of 24 nM. Furthermore, BMS-986251 exhibits strong therapeutic effects in mouse acanthosis and Imiquimod-induced models, which are commonly used preclinical models for psoriasis.
价 格:¥电议型 号:T40123产 地:中国大陆
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T39442AM-8123;AM-8123AM-8123
AM-8123 is an APJ agonist with high oral bioavailability and potency. It effectively inhibits Forskolin-stimulated cAMP production and activates Gα proteins. This compound is valuable for cardiovascular disease research.
价 格:¥电议型 号:T39442产 地:中国大陆
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T39123Givosiran;GivosiranALN-AS1|||Givosiran;ALN-AS1|||Givosiran
Givosiran (ALN-AS1) is a small interfering RNA (siRNA) compound that specifically targets hepatic aminolevulinate synthase 1 (ALAS1) messenger RNA (mRNA) to downregulate its expression. By doing so, Givosiran effectively inhibits the accumulation of neurotoxic δ-aminolevulinic acid and porphobilinogen levels. This compound holds significant potential for further research on acute intermittent porphyria.
价 格:¥电议型 号:T39123产 地:中国大陆
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T38617LBiotin-TAT (47-57) acetate;化合物Biotin-TAT (47-57) acetateBiotin-TAT (47-57) acetate(1231898-25-1 free
Biotin-TAT (47-57) acetate is a biotin-labeled TAT polypeptide and a transactivator of transcription. Biotin-TAT (47-57) acetate is one of the most widely used peptides in protein transduction domains.
价 格:¥电议型 号:T38617L产 地:中国大陆
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T38521Patamostat mesylatePatamostat mesylateE-3123 mesylate
Patamostat mesylate (E-3123) is a highly potent protease inhibitor, displaying strong inhibitory activity against trypsin, plasmin, and thrombin, with IC 50 values of 39 nM, 950 nM, and 1.9 μM, respectively. This compound, Patamostat mesylate, shows promising potential in suppressing the pathogenesis and development of acute pancreatitis.
价 格:¥电议型 号:T38521产 地:中国大陆
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T381235(6)-Carboxy-2′,7′-dichlorofluorescein diacetate;5(6)-Carboxy-2′,7′-dichlorofluorescein diacetate5(6
5(6)-Carboxy-2’,7’-dichlorofluorescein diacetate is an oxidant-sensitive and cell-permeable fluorescent probe.1Base hydrolysis of the ester bonds by intracellular esterases releases the acetate groups and the resulting compound, 5(6)-carboxy-2’,7’,-dichlorofluorescein, is oxidized by reactive oxygen species (ROS) and nitric oxide (NO) and displays excitation/emission maxima of 504 and 530 nm, respectively, which can be quantified as a measure of oxidant production.
价 格:¥电议型 号:T38123产 地:中国大陆
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T371231,2-Dioctanoyl PC;1,2-Dioctanoyl PC1,2-Dioctanoyl PC
Phosphatidylcholine (PC) species are a common class of phospholipids that comprise the mammalian cell membrane. 1,2-Dioctanoyl PC is a synthetic analog of natural phosphatidylcholine species containing saturated C8:O fatty acids in the sn-1 and sn-2 positions of the glycerol backbone. It exhibits a critical micelle concentration (CMC) value of 0.25 mM at 27°C. 1,2-Dioctanoyl PC serves as an efficient substrate for phospholipase D (PLD) as well as sPLA2 isozymes from bovine pancreas and bee venom
价 格:¥电议型 号:T37123产 地:中国大陆
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T361233-Phenyltoxoflavin;化合物3-PhenyltoxoflavinZINC267655|||Phenyltoxoflavin;ZINC267655|||Phenyltoxoflavin
3-Phenyltoxoflavin (Phenyltoxoflavin) is an inhibitor of HSP90 (Kd = 585 nM) with anti-cancer activity.
价 格:¥电议型 号:T36123产 地:中国大陆
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T35114WAY-123398 free base;化合物 T35114Way-123398|||Way 123398|||Way 123,398|||Way123398|||Way-123,398|||Way
Way 123398 is a class III antiarrhythmic agent.
价 格:¥电议型 号:T35114产 地:中国大陆
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T35110Way 123783;化合物 T35110Way-123783|||Way123783;Way-123783|||Way123783
Way 123783 is a bioactive chemical.
价 格:¥电议型 号:T35110产 地:中国大陆
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T35109Way 123223;化合物 T35109Way123223|||Way-123223;Way123223|||Way-123223
Way 123223 is a bioactive chemical.
价 格:¥电议型 号:T35109产 地:中国大陆
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T34939Triethyl aconitate;化合物 T34939AI3 11238|||AI311238|||AI3-11238;AI3 11238|||AI311238|||AI3-11238
Triethyl aconitate is a biochemical.
价 格:¥电议型 号:T34939产 地:中国大陆
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T34508Sanazole;化合物 T34508AK2123|||AK-2123|||AK 2123;AK2123|||AK-2123|||AK 2123
Sanazole is a 3-nitrotriazole cpd. It can affect the human cervical cancer cell line.
价 格:¥电议型 号:T34508产 地:中国大陆
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T34387Ronomilast;化合物 RonomilastAWD 12353|||ELB-353|||Elbimilast|||ELB353|||ELB 353;AWD 12353|||ELB-353|||E
Ronomilast (ELB353) can be used in the study of obstructive pulmonary disease.
价 格:¥电议型 号:T34387产 地:中国大陆