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T15621Rilematovir;化合物RilematovirJNJ-53718678|||JNJ-678;JNJ-53718678|||JNJ-678
Rilematovir (JNJ-678) is an inhibitor of fusion protein with antiviral activity and low cytotoxicity. Rilematovir can be used in studies about respiratory syncytial virus treatment.
价 格:¥电议型 号:T15621产 地:中国大陆
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T15619JNJ-46778212;化合物 JNJ-46778212VU 0409551;VU 0409551
JNJ-46778212 (VU 0409551) is a selective and potent mGlu5 allosteric modulator (EC50: 260 nM) for the study of neurodissection.
价 格:¥电议型 号:T15619产 地:中国大陆
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T15578Indotecan;化合物IndotecanNSC-724998|||LMP-400;NSC-724998|||LMP-400
Indotecan (LMP-400) is an effective inhibitor of topoisomerase 1(Top1) (IC50: 300, 1200, 560 nM for P388, HCT116, MCF-7 cell lines, respectively).
价 格:¥电议型 号:T15578产 地:中国大陆
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T1546Nitazoxanide;硝唑尼特NSC 697855;NSC 697855|||硝唑尼特
Nitazoxanide (NSC-697855) is a synthetic benzamide with antiprotozoal activity. Nitazoxanide exerts its antiprotozoal activity by interfering with the pyruvate ferredoxin/flavodoxin oxidoreductase dependent electron transfer reaction.
价 格:¥电议型 号:T1546产 地:中国大陆
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T15435GSK2837808A;化合物GSK2837808AGSK2837808A
GSK2837808A is a potent and selective inhibitor of lactate dehydrogenase A (LDHA) (IC50s: 1.9 and 14 nM for LDHA and LDHB, respectively).
价 格:¥电议型 号:T15435产 地:中国大陆
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T15412GPP78;化合物 T15412CAY10618;CAY10618
GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-cancer and anti-inflammatory effects.
价 格:¥电议型 号:T15412产 地:中国大陆
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T15405GNE-781;GNE-781GNE-781
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, respectively).
价 格:¥电议型 号:T15405产 地:中国大陆
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T15278Fezolinetant;化合物FezolinetantESN-364;ESN-364
Fezolinetant (ESN-364) is an antagonist of the neurokinin 3 receptor (NK3R). It is used for the treatment of menopausal hot flushes.
价 格:¥电议型 号:T15278产 地:中国大陆
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T15209Elobixibat;依洛西巴特AZD 7806|||A 3309;AZD 7806|||A 3309
Elobixibat (A 3309) is an inhibitor of the ileal bile acid transporter (IC50: 0.13 nM, 0.53 nM, and 5.8 nM for mouse, human, and canine IBAT). Elobixibat can be used in studies about chronic idiopathic constipation.
价 格:¥电议型 号:T15209产 地:中国大陆
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T15178dTRIM24;化合物dTRIM24dTRIM24
dTRIM24 is a selective bifunctional TRIM24 degradation agent based on PROTAC technology, consisting of the ligands von Hippel-Lindau and TRIM24.
价 格:¥电议型 号:T15178产 地:中国大陆
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T15136LDiZPK Hydrochloride (1337883-32-5 free base);化合物 T15136LDiZPK Hydrochloride;DiZPK Hydrochloride
DiZPK Hydrochloride is a structural analog of pyrrolysine (Pyl), acting as a photocrosslinker for identifying direct protein-protein interactions in living prokaryotic and eukaryotic cells.
价 格:¥电议型 号:T15136L产 地:中国大陆
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T15078DBCO-Sulfo-NHS ester sodium;化合物 T15078DBCO-Sulfo-NHS ester sodium
DBCO-Sulfo-NHS ester sodium is a cleavable linker predominantly employed in the synthesis of antibody-drug conjugates (ADCs)[1].
价 格:¥电议型 号:T15078产 地:中国大陆
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T14978CL-82198;化合物CL-82198CL-82198
CL-82198, a selective MMP-13 inhibitor, serves as a pharmacological intervention to halt the progression of osteoarthritis (OA). Its mechanism of action involves binding to the S1’ pocket of MMP-13, ensuring its selectivity and preventing inhibition of other MMPs.
价 格:¥电议型 号:T14978产 地:中国大陆
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T14878CAY10566;化合物CAY10566CAY10566
CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively..
价 格:¥电议型 号:T14878产 地:中国大陆
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T14789Bromo-PEG2-C2-acid;化合物 T14789Bromo-PEG2-C2-acid
Bromo-PEG2-C2-acid is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T14789产 地:中国大陆
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T14788Bromo-PEG2-bromide;化合物 T14788Bromo-PEG2-bromide
Bromo-PEG2-bromide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T14788产 地:中国大陆
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T14787Bromo-PEG2-alcohol;化合物 T14787Bromo-PEG2-alcohol
Bromo-PEG2-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T14787产 地:中国大陆
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T14786Bromo-PEG1-CH2COOH;化合物 T14786Bromo-PEG1-CH2COOH
Bromo-PEG1-CH2COOH is a PROTAC linker can be used in the synthesis of PROTACs[1].
价 格:¥电议型 号:T14786产 地:中国大陆
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T14785Bromo-PEG1-CH2-Boc;化合物 T14785Bromo-PEG1-CH2-Boc
Bromo-PEG1-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T14785产 地:中国大陆
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T14784Bromo-PEG1-C2-Boc;化合物 T14784Bromo-PEG1-C2-Boc
Bromo-PEG1-C2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T14784产 地:中国大陆