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T11373GCN2-IN-1；化合物GCN2-IN-1A-92；A-92
GCN2-IN-1 (A-92) is an effective GCN2 inhibitor and can be used in research on the treatment of cancer as a chemotherapeutic agent.
价 格：￥电议型 号：T11373产 地：中国大陆
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T11321FR194738 free base；化合物FR194738 free baseFR194738 free base
FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.?
价 格：￥电议型 号：T11321产 地：中国大陆
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T11320FR194738；化合物FR194738FR194738
FR194738 is an inhibitor of squalene epoxidase with an IC50 of 9.8 nM in HepG2 cell homogenates.
价 格：￥电议型 号：T11320产 地：中国大陆
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T11282LFGTI-2734 mesylate (1247018-19-4 free base)；化合物 T11282LFGTI-2734 mesylate；FGTI-2734 mesylate
FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors.
价 格：￥电议型 号：T11282L产 地：中国大陆
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T11282FGTI-2734；化合物FGTI-2734FGTI-2734
FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localization of KRAS, addressing the issue of KRAS resistance and inhibiting the growth of mutant KRAS patient-derived pancreatic tumors.
价 格：￥电议型 号：T11282产 地：中国大陆
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T11273Fenpiverinium D3 bromide；化合物 T11273Fenpiverinium D3 bromide
Fenpiverinium bromide has anti-cholinergic and anti-spasmodic effects.Fenpiverinium D3 bromide is a deuterium labeled Fenpiverinium bromide.
价 格：￥电议型 号：T11273产 地：中国大陆
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T11173LElacestrant S enantiomer dihydrochloride；化合物 T11173LRAD1901 S enantiomer dihydrochloride|||RAD-1901
Elacestrant (RAD1901) dihydrochloride is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively. Elacestrant S enantiomer dihydrochloride is an low activity enantiomer of elacestrant dihydrochloride.
价 格：￥电议型 号：T11173L产 地：中国大陆
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T11173Elacestrant S enantiomer；化合物 T11173RAD1901 S enantiomer；RAD1901 S enantiomer
Elacestrant S enantiomer is a selective and orally available estrogen receptor (ERR) degrader with IC50 values of 48 and 870 nM for ERα and ERβ, respectively.
价 格：￥电议型 号：T11173产 地：中国大陆
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T11136E-7386；化合物E-7386E7386；E7386
E-7386 is an oral active CBP/ -catenin modulator.
价 格：￥电议型 号：T11136产 地：中国大陆
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T11126Durvalumab；度伐利尤单抗MEDI 4736；MEDI 4736
Durvalumab (MEDI 4736) is a humanized monoclonal antibody targeting PD-L1. It can block the interaction of PD-L1 with PD-1 and CD80, with IC50 values of 0.1 and 0.04 nM, respectively. Durvalumab is often used in combination with platinum-based compounds for the treatment of non-small cell lung cancer and advanced hepatocellular carcinoma cells.
价 格：￥电议型 号：T11126产 地：中国大陆
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T11079NMI 8739；化合物NMI 8739n-docosahexaenoyl dopamine|||Dha-DA conjugate；n-docosahexaenoyl dopamine|||Dha-D
NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.
价 格：￥电议型 号：T11079产 地：中国大陆
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T11073Dofetilide N-oxide；化合物 T11073UK-116856；UK-116856
Dofetilide N-oxide (UK-116856) is a metabolite of dofetilide. Dofetilide can block potassium channels and is a tertiary antiarrhythmic drug.
价 格：￥电议型 号：T11073产 地：中国大陆
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T1102Mifepristone；米非司酮C-1073|||RU486|||RU 38486；C-1073|||RU486|||RU 38486|||米非司酮
Mifepristone (C-1073) is a Progestin Antagonist. The mechanism of action of mifepristone is as a Progestational Hormone Receptor Antagonist.
价 格：￥电议型 号：T1102产 地：中国大陆
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T11014DFP00173；化合物DFP00173DFP00173
DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with IC50 of ~0.1-0.4 μM. Compared with the homologous AQP subtypes AQP7 and AQP9, DFP00173 is selective for AQP3.
价 格：￥电议型 号：T11014产 地：中国大陆
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T10973DC41SMe；化合物 T10973DC41SMe
DC41SMe is a DC1 derivative that is cytotoxic to Ramos, Namalwa and HL60 / s with IC50s ranging from 18-25 pM. DC1 is a simplified analogue of CC-1065, an antibody conjugate of cytotoxic DNA alkylation molecules, used for targeted treatment of cancer.
价 格：￥电议型 号：T10973产 地：中国大陆
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T10873CP-96486；化合物 T10873CP-96486
CP-96486 is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor (Kis: 20 and 24 nM).
价 格：￥电议型 号：T10873产 地：中国大陆
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T10856Cobimetinib (R-enantiomer)；考比替尼 (R 型对映体)XL-518 R-enantiomer|||Cobimetinib R-enantiomer|||GDC-0973 R-
Cobimetinib R-enantiomer is the less active R-enantiomer of Cobimetinib which is a selective MEK inhibitor.
价 格：￥电议型 号：T10856产 地：中国大陆
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T10848CMLD012073；化合物 T10848CMLD012073
CMLD012073 is a potent eukaryotic initiation factor 4A (eIF4A) inhibitor. It inhibits NIH/3T3 cells (IC50: 10 nM). CMLD012073 inhibits eukaryotic translation initiation by modifying the behavior of the RNA helicase (eIF4A).
价 格：￥电议型 号：T10848产 地：中国大陆
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T10773CF53；化合物CF53CF53
CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo.
价 格：￥电议型 号：T10773产 地：中国大陆
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T10739CDK8/19-IN-1；化合物 T10739CDK8/19-IN-1
CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).
价 格：￥电议型 号：T10739产 地：中国大陆
