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T11701J22352；化合物 T11701J22352
J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblastoma by promoting HDAC6 degradation. It does so by inhibiting autophagy and stimulating the antitumor immune response, further restoring host antitumor activity through the reduction of PD-L1´s immunosuppressive activity.
价 格：￥电议型 号：T11701产 地：中国大陆
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T11700J-2156；化合物 T11700J-2156
The ED50 of J-2156 in rats for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws was 3.7 and 8.0 mg/kg, respectively. J-2156 is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively.
价 格：￥电议型 号：T11700产 地：中国大陆
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T1170Olopatadine hydrochloride；盐酸奥洛他定Olopatadine HCl|||KW4679|||ALO4943A；盐酸奥洛他定|||Olopatadine HCl|||KW467
Olopatadine hydrochloride (ALO4943A) is an antihistamine with mast-cell stabilizing properties used as eye drops in the treatment of ALLERGIC CONJUNCTIVITIS.
价 格：￥电议型 号：T1170产 地：中国大陆
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T116970TLC3407-3786；化合物 TLC3407-3786TLC3407-3786
MMV665916 is a quinazolinedione derivative that is an antimalarial agent. MMV665916 shows remarkable antiplasmodial activity against P. falciparum FcB1 strain with EC 50 value of 0.4 μM and presents the high selectivity index (SI>250) [1].
价 格：￥电议型 号：T116970产 地：中国大陆
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T11670IRAK inhibitor 3；化合物IRAK inhibitor 3IRAK inhibitor 3
IRAK inhibitor 3 is an interleukin-1 (IL-1) receptor-associated kinase (IRAK) modulator.
价 格：￥电议型 号：T11670产 地：中国大陆
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T11570HL271；化合物 T11570HL271
HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.
价 格：￥电议型 号：T11570产 地：中国大陆
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T11499GSK726701A；化合物 T11499GSK726701A
GSK726701A is a new type of prostaglandin E2 receptor 4 (EP4) partial agonist (pEC50: 7.4).
价 格：￥电议型 号：T11499产 地：中国大陆
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T11470GSK 366；化合物 T11470GSK 366
GSK 366 is a potent kynurenine-3-monooxygenase (KMO) inhibitor (IC50s: 0.7 nM and 2.3 nM for P. fluorescens-KMO and human KMO).
价 格：￥电议型 号：T11470产 地：中国大陆
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T11408Orforglipron；奥格列隆LY3502970|||GLP-1 receptor agonist 1；LY3502970|||GLP-1 receptor agonist 1
Orforglipron (LY3502970; GLP-1 receptor agonist 1) is an orally available glucagon-like peptide (GLP-1) receptor agonist for the study of obesity and type 1 diabetes in adults.
价 格：￥电议型 号：T11408产 地：中国大陆
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T11390GENZ-882706；化合物 T11390RA03546849；RA03546849
GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.
价 格：￥电议型 号：T11390产 地：中国大陆
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T11370GB-88；化合物 T11370GB-88
GB-88 is an selective , oral non-peptide antagonist of PAR2, inhibits PAR2 activated Ca2+ release with an IC50 of 2 μM.
价 格：￥电议型 号：T11370产 地：中国大陆
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T11369LGB-110 hydrochloride (1252806-70-4 free base)；化合物 T11369LGB-110 hydrochloride；GB-110 hydrochloride
GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist.
价 格：￥电议型 号：T11369L产 地：中国大陆
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T11352Galidesivir triphosphate；化合物 T11352BCX4430-triphosphate|||Immucillin-A triphosphate|||BCX6870；BCX443
Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA polymerase activity and protects mice against Ebola. Galidesivir triphosphate (Immucillin-A triphosphate) is converted by the prodrug Galidesivir.
价 格：￥电议型 号：T11352产 地：中国大陆
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T11324FRG8701；化合物 T11324FRG8701
FRG8701 is a new Histamine H2-receptor antagonist with an IC50 of ranging from 0.25 to 0.43 μM.
价 格：￥电议型 号：T11324产 地：中国大陆
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T11282LFGTI-2734 mesylate (1247018-19-4 free base)；化合物 T11282LFGTI-2734 mesylate；FGTI-2734 mesylate
FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates KRAS resistance by preventing its membrane localization, effectively impeding mutant KRAS patient-derived pancreatic tumors.
价 格：￥电议型 号：T11282L产 地：中国大陆
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T1124Flumethasone氟米松氟米松|||Flumetasone|||RS-2177|||NSC-54702
Flumethasone (RS-2177) is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties.
价 格：￥电议型 号：T1124产 地：中国大陆
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T11170eIF4A3-IN-1；化合物 T11170eIF4A3-IN-1
eIF4A3-IN-1 is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD.
价 格：￥电议型 号：T11170产 地：中国大陆
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T11150Ecteinascidin 770；化合物 T11150Ecteinascidine 770|||Et-770；Ecteinascidine 770|||Et-770
Ecteinascidin 770 (ET-770) inhibits U373MG cells and is a 1,2,3, 4-tetrahydroisoquinoline alkaloid with strong anticancer activity.IC50 is 4.83 nM.
价 格：￥电议型 号：T11150产 地：中国大陆
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T11070LDO34；化合物 T11070LDO34
DO34 is a highly potent and centrally active inhibitor of diacylglycerol lipase (IC50: 6 nM for DAGLα conversion of SAG to 2-AG).
价 格：￥电议型 号：T11070L产 地：中国大陆
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T11070DO34 analog；化合物DO34 analogDO34 analog
DO34 analog is a triazole DAGL(α) inhibitor.
价 格：￥电议型 号：T11070产 地：中国大陆
