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T15286Flindokalner；化合物FlindokalnerBMS-204352；BMS-204352
Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner displays a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM) and acts as a negative modulator of GABAA receptors and it also shows anxiolytic efficacy in vivo.
价 格：￥电议型 号：T15286产 地：中国大陆
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T14967Cimlanod；化合物 T14967BMS-986231|||CXL-1427；BMS-986231|||CXL-1427
Cimlanod is a second-generation Nitroxyl (HNO) donor for heart failure with positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream.
价 格：￥电议型 号：T14967产 地：中国大陆
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T14690BMS 433796；化合物BMS 433796BMS-289948|||BMS-299897；BMS-289948|||BMS-299897
BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer´s disease.
价 格：￥电议型 号：T14690产 地：中国大陆
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T14689BMS493；化合物 BMS493BMS-493；BMS-493
BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with RARs, attenuates RA signaling, potentiates TPP-induced toxicity, and inhibits the increase in phospholipase A2 activity.
价 格：￥电议型 号：T14689产 地：中国大陆
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T14688BMS CCR2 22；化合物BMS CCR2 22BMS CCR2 22
BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.
价 格：￥电议型 号：T14688产 地：中国大陆
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T14687Deucravacitinib；化合物BMS-986165BMS-986165；BMS-986165
Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain.
价 格：￥电议型 号：T14687产 地：中国大陆
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T14686BMS-986163；化合物 T14686BMS-986163
BMS-986163 is a negative allosteric modulator of GluN2B and the prodrug BMS-986163 rapidly converts to its active parent molecule BMS-986169 (Ki=4 nM, IC50=24 nM).
价 格：￥电议型 号：T14686产 地：中国大陆
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T14685BMS-986158；化合物BMS-986158BMS-986158
BMS-986158 is a highly effective BET inhibitor, demonstrating IC50 values of 6.6 nM in NCI-H211 small cell lung cancer (SCLC) cells and 5 nM in MDA-MB231 triple negative breast cancer (TNBC) cells.
价 格：￥电议型 号：T14685产 地：中国大陆
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T14684BMS-986120；化合物 T14684BMS-986120
BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist. With IC50s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects[1][2].
价 格：￥电议型 号：T14684产 地：中国大陆
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T14683BMS-983970；化合物 T14683BMS-983970
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
价 格：￥电议型 号：T14683产 地：中国大陆
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T14682BMS-962212；化合物 T14682BMS-962212
BMS-962212, a direct, reversible, and selective factor XIa (FXIa) inhibitor, demonstrates fast pharmacodynamic (PD) response onset and rapid elimination with a well-tolerated profile. It dependently increases activated partial thromboplastin time and decreases FXI clotting activity exposure [1].
价 格：￥电议型 号：T14682产 地：中国大陆
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T14681BMS-935177；化合物BMS-935177BMS-935177
BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.
价 格：￥电议型 号：T14681产 地：中国大陆
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T14680BMS-906024；化合物 BMS-906024Osugacestat|||AL-101|||BM-0018；Osugacestat|||AL-101|||BM-0018
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively.
价 格：￥电议型 号：T14680产 地：中国大陆
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T14678BMS-819881；化合物 T14678BMS-819881
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A4 activity with an EC50 of 13 μM.
价 格：￥电议型 号：T14678产 地：中国大陆
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T14677BMS-690514；化合物BMS-690514BMS-690514
BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.
价 格：￥电议型 号：T14677产 地：中国大陆
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T14676BMS-688521化合物 BMS-688521BMS688521|||BMS 688521
BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity.
价 格：￥电议型 号：T14676产 地：中国大陆
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T14675BMS-564929；化合物 T14675BMS-564929
BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).
价 格：￥电议型 号：T14675产 地：中国大陆
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T14674BMS-509744；化合物 T14674BMS-509744
BMS-509744 is an inhibitor of ATP competitive Itk (IC50: 19 nM).
价 格：￥电议型 号：T14674产 地：中国大陆
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T14673BMS 299897；化合物BMS 299897BMS 299897
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).
价 格：￥电议型 号：T14673产 地：中国大陆
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T14672BMS-248360；化合物 T14672BMS-248360
BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor. With Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 shows hypertensive effects[1].
价 格：￥电议型 号：T14672产 地：中国大陆
