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T13247UK-101;化合物UK-101UK101|||UK 101;UK101|||UK 101
UK-101 is a potent and selective inhibitor of the immunoproteasome LMP2, inhibiting β1i (LMP2), β1c (LMP2), and β5 (LMP2), with IC50s of 104 nM, 15 μM, and 1 μM. UK-101 has a 144-fold and 10-fold higher affinity for β1i than for the distribution of β1c and β5 subunits. UK-101 induces apoptosis and can be used to study prostate cancer related diseases.
价 格:¥电议型 号:T13247产 地:中国大陆
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T13097TBK1/IKKε-IN-1;化合物 T13097TBK1/IKKε-IN-1
TBK1/IKKε-IN-1 is a dual inhibitor of TBK1 and IKKε (IC50s of <100 nM).
价 格:¥电议型 号:T13097产 地:中国大陆
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T12927SK1-IN-1;化合物 T12927SK1-IN-1
SK1-IN-1 is a potent inhibitor of sphingosine kinase 1 (SPHK1)(IC50 of 58 nM).
价 格:¥电议型 号:T12927产 地:中国大陆
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T12891SGK1-IN-2;化合物 T12891SGK1-IN-2
SGK1-IN-2 (14h) is a selective inhibitor of SGK1 (serum and glucocorticoid regulated kinase 1)(with an IC50 of 5 nM at 10 μM ATP concentration).
价 格:¥电议型 号:T12891产 地:中国大陆
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T12890SGK1-IN-1;化合物 T12890SGK1-IN-1
SGK1-IN-1 is a highly active and selective SGK-1 inhibitor(IC50 of 1 nM).
价 格:¥电议型 号:T12890产 地:中国大陆
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T12885SGC-AAK1-1;化合物SGC-AAK1-1SGC-AAK1-1
SGC-AAK1-1 is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) (IC50 of 270 nM and a Ki of 9 nM),and is a chemical probe.
价 格:¥电议型 号:T12885产 地:中国大陆
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T127402Coenzyme Q0;化合物 STOCK1N-17426CoQ0;CoQ0
Coenzyme Q0 (CoQ0), a potent, orally active ubiquinone compound derived from Antrodia cinnamomea, induces apoptosis and autophagy. It suppresses HER-2/AKT/mTOR signaling, enhancing apoptosis and autophagy mechanisms. Additionally, Coenzyme Q0 regulates NFκB/AP-1 activation and promotes Nrf2 stabilization, contributing to the attenuation of inflammation and redox imbalance. It also exhibits anti-angiogenic activity by downregulating MMP-9/NF-κB and upregulating HO-1 signaling.
价 格:¥电议型 号:T127402产 地:中国大陆
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T12731RIPK1-IN-7;化合物RIPK1-IN-7RIPK1-IN-7
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model.
价 格:¥电议型 号:T12731产 地:中国大陆
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T12730RIPK1-IN-4;化合物RIPK1-IN-4RIPK1-IN-4
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase).
价 格:¥电议型 号:T12730产 地:中国大陆
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T12729RIPK1-IN-3;化合物 T12729RIPK1-IN-3
RIPK1-IN-3 is a RIPK1 inhibitor, with anti-inflammatory proprieties.
价 格:¥电议型 号:T12729产 地:中国大陆
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T12398MP7;PDK1 抑制剂PDK1 inhibitor;PDK1 抑制剂|||PDK1 inhibitor
MP7 (PDK1 inhibitor) is a inhibitor of phosphoinositide-dependent kinase-1 (PDK1).
价 格:¥电议型 号:T12398产 地:中国大陆
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T11943MAPK13-IN-1;MAPK13抑制剂1MAPK13-IN-1
MAPK13-IN-1 is a potent MAPK13 (p38δ) inhibitor (IC50: 620 nM).
价 格:¥电议型 号:T11943产 地:中国大陆
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T11739K145;化合物 T11739K145
K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity. K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 μM and a Ki of 6.4 μM.
价 格:¥电议型 号:T11739产 地:中国大陆
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T11479GSK1521498;化合物 T11479GSK1521498
GSK1521498 is a selective antagonist of the μ-opioid receptor (MOR). It is being used for the treatment of disorders of compulsive consumption of food, alcohol, and drugs.
价 格:¥电议型 号:T11479产 地:中国大陆
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T11478LGSK1521498 free base;化合物 T11478LGSK1521498 free base
GSK1521498 free base is a potent and selective antagonist of the μ-opioid receptor. GSK1521498 free base also has the potential for disorders of compulsive consumption of food, alcohol, and drugs.
价 格:¥电议型 号:T11478L产 地:中国大陆
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T11478GSK1521498 free base (hydrochloride);化合物 T11478GSK1521498 free base (hydrochloride)
GSK1521498 free base (hydrochloride) is a selective antagonist of the μ-opioid receptor (MOR). It is being used for the treatment of disorders of compulsive consumption of food, alcohol, and drugs.
价 格:¥电议型 号:T11478产 地:中国大陆
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T11477GSK1059865;化合物 T11477GSK1059865
GSK1059865 is a potent antagonist of the orexin 1 receptor.
价 格:¥电议型 号:T11477产 地:中国大陆
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T11293(±)-Fabesetron hydrochloride;化合物 T11293FK1052 hydrochloride;FK1052 hydrochloride
FK1052 hydrochloride is a potent 5-HT3 and 5-HT4 receptor dual antagonist.
价 格:¥电议型 号:T11293产 地:中国大陆
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T11226ERK1/2 inhibitor 1;化合物 T11226ERK1/2 inhibitor 1
ERK1/2 inhibitor 1 is a potent, orally bioavailable ERK1/2 inhibitor, showing 60% inhibition at 1 nM and an IC50 of 3.0 nM against ERK1 and ERK2, respectively.
价 格:¥电议型 号:T11226产 地:中国大陆
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T11129Duvelisib (R enantiomer)化合物Duvelisib R entiomerDuvelisib R enantiomer|||IPI-145 R enantiomer|||INK11
Duvelisib R enantiomer (IPI-145 R enantiomer) is an enantiomer of Duvelisib with lower activity. Duvelisib is a PI3K inhibitor.
价 格:¥电议型 号:T11129产 地:中国大陆