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Ʒ86101
ι۴3751122
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T11023DHODH-IN-14DHODH IN 14,DHODHIN14
DHODH-IN-14 is an analog of hydroxyfuran pyrimidine A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor IC50 0.49 M mouse liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis.
ţT11023 أй½
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TP1789LMalantide acetate(86555-35-3 free base)Malantide acetate(86555 35 3 free base),Malantide acetate(865
Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptide that is phosphorylated by PKA and is used to measure PKA activity in vitro.
ţTP1789L أй½
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T16536Pimonidazole hydrochlorideinhibit,Pimonidazole hydrochloride,Pimonidazole,Inhibitor
Pimonidazole hydrochloride accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after the reduction of its nitro group. It can be used for qualitative and quantitative assessment of tumor hypoxia. Pimonidazole hydrochloride is a novel hypoxia marker for the complementary study of tumor hypoxia and cell proliferation in tumors.
ţT16536 أй½
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TN1438beta-Amyrin acetateHMG-CoA,betaAmyrin acetate,LDL,Fungal,inhibit,Inhibitor,arthritic,hemolysis,antif
beta-Amyrin acetate inhibits HMG-CoA Reductase (HMGCR) and sEH activity with IC50 of 3.4 M. beta-Amyrin acetate has anti-inflammatory, antifungal, antioxidant, and anti-hyperlipidemic activities.
ţTN1438 أй½
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T23128PD180970PD-180970,PD180970
PD180970 is an inhibitor of Bcr-Abl with IC50s of 5 nM, 0.8 nM and 50 nM for the autophosphorylation of p210Bcr-Abl, Src and Kit. PD180970 can be used in studies about chronic myelogenous leukemia.
ţT23128 أй½
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TN4871PyrolinPyrolin
Pyrolin has a strong antifungal activity and exerts a potent impact on the ultrastructure of M.fructicola.
ţTN4871 أй½
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T61392NLRP3-IN-10
NLRP3-IN-10 is a potent NLRP3 inhibitor. NLRP3-IN-10 inhibits IL-1 release with an IC50 value of 251.1 nM. NLRP3-IN-10 attenuates ASC speck formation, leading to suppress activation of NLRP3 inflammasome.
ţT61392 أй½
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T9192BIIB068ADME,inhibit,FcR,Autoimmune,Bruton tyrosine kinase,TNF,BIIB 068,ROS,Inhibitor,reversible,Bt
BIIB068 is an selective, reversible and orally active BTK inhibitor (IC50 = 1 nM, Kd = 0.3 nM). BIIB068 is 400 times more selective for BTK than other kinases.
ţT9192 أй½
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TP1898HS024selective,melanocortin,intake,Inhibitor,Melanocortin Receptor,MC Receptor,HS-024,food,HS024,inh
Highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks -MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo.
ţTP1898 أй½
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TN1768IriflophenoneInhibitor,MCF-7,proliferation,Iriflophenone,cells,T-47D,inhibit
Iriflophenone?stimulates cells proliferation in?MCF-7 and T-47D human breast cancer.
ţTN1768 أй½
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T5373Acrizanib
Acrizanib is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-VEGFR-2.
ţT5373 أй½
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TJS03384-Methylesculetininhibit,4 Methylesculetin,Glutathione Peroxidase,4-Methylesculetin,Inhibitor,4Methy
4-methylesculetin is one of the coumarin derivatives with great anti-oxidant and anti-inflammatory activities.
ţTJS0338 أй½
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T9645CU-115
CU-115 is a selective and potent TLR8 antagonist with IC50 of 1.04 ?M and =>50 ?M for TLR8 and TLR7, respectively. CU-115 decreases production of TNF- and IL-1 activated by R-848 in THP-1 cells.
ţT9645 أй½
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T7400RRX-001Parasite,RRx-001,RRX 001,Apoptosis,Inhibitor,inhibit,RRX001
RRx-001 is a potent inhibitor ofglucose 6-phosphate dehydrogenase(G6PD) and with potent antimalarial activity
ţT7400 أй½
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T67749Fuzapladib
Fuzapladib (IS-741) is a phospholipase A2 inhibitor that can inhibits the expression of Mac-1, a cell adhesion molecule. Fuzapladib blocks activation of adhesion molecules (integrin) expressed on the inflammatory cell surface to prevent inflammatory cells from adhering to vascular endothelial cells and infiltrating tissue and to control exacerbation of pancreatitis.
ţT67749 أй½
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T67777Flaviviruses-IN-3
Flaviviruses-IN-3 (compound 87) is a potent inhibitor of flaviviruse. Flaviviruses-IN-3 could reduce the WNV (West Nile virus) protease activity, with a inhibition of 54%.
ţT67777 أй½
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TQ0015PRN1371inhibit,CSF1R,PRN 1371,Inhibitor,colony stimulating factor 1 receptor,c-Fms,CSF-1R,FGFR,CSF-1
PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).
ţTQ0015 أй½
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TN2079(-)-Pinoresinol()Pinoresinol,( ) Pinoresinol
(-)-Pinoresinol is isolated from the whole plant of Serissa japonica (Thunb.) Thunb.
ţTN2079 أй½
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T60146USP8-IN-1USP8inhibitor
USP8-IN-1 is an inhibitor of USP8 with an IC 50 of 1.9 M. USP8-IN-1 inhibits H1975 cell growth with a GI 50 of 82.04 M [1].
ţT60146 أй½