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  • T37437C17 Ceramide (d18:1/17:0)；C17 Ceramide (d18:1/17:0)C17 Ceramide (d18:1/17:0)

    C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine. It has been used as a marker of arylsulfatase A and sphingolipid activator B activity in patients undergoing enzyme replacement therapy for the genetic disease metachromatic leukodystrophy.

    价 格：￥电议型 号：T37437产 地：中国大陆

  • T37436C12-Ceramide；化合物 C12-CeramideN-Laurylsphingosine|||C12 Ceramide (d18:1/12:0)|||N-Lauroyl-D-erythro-s

    C12-Ceramide (C12 Ceramide (d18:1/12:0)), a ceramide present in the protective membranes surrounding umbilical cord blood vessels in infants born to women with pre-eclampsia, can be used to assess the level of ASM activity in the plasma of patients with Niemann-Pick disease.

    价 格：￥电议型 号：T37436产 地：中国大陆

  • T37291Lyso-Globotriaosylceramide (d18:1)；Lyso-Globotriaosylceramide (d18:1)Lyso-Globotriaosylceramide (d18

    Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry diseas

    价 格：￥电议型 号：T37291产 地：中国大陆

  • T37187D-erythro/L-threo Lysosphingomyelin (d18:1)；D-erythro/L-threo Lysosphingomyelin (d18:1)D-erythro/L-t

    Lysosphingomyelin is an endogenous bioactive sphingolipid and a constituent of lipoproteins.1,2It is produced by the removal of the acyl group from sphingomyelin by a deacylase and acts as a precursor in the biosynthesis of sphingosine-1-phosphate . D-erythroLysosphingomyelin is an agonist of the S1P receptors S1P1, S1P2, and S1P3(EC50s = 167.7, 368.1, and 482.6 nM, respectively, for the human receptors).3It is also an agonist of the orphan receptor ovarian cancer G protein-coupled receptor 1 (O

    价 格：￥电议型 号：T37187产 地：中国大陆

  • T37010D-threo Sphinganine (d18:0)；D-threo Sphinganine (d18:0)D-threo Sphinganine (d18:0)；D-threo Sphingani

    D-threo Sphinganine (d18:0) is a synthetic bioactive sphingolipid and stereoisomer of sphinganine (d18:0) and L-erythro sphinganine (d18:0) . It induces autophagy in HCT116 cells when used at a concentration of 12 μM. D-threo Sphinganine (d18:0) is metabolized via sphinganine N-acyltransferase and sphinganine kinase in vivo in rat liver.

    价 格：￥电议型 号：T37010产 地：中国大陆

  • T36987N,N-dimethyl Sphinganine (d18:0)；N,N-dimethyl Sphinganine (d18:0)N,N-dimethyl Sphinganine (d18:0)；N,

    N,N-dimethyl Sphinganine (d18:0) is a sphingolipid that increases during development ofL. donovanipromastigotes.1

    价 格：￥电议型 号：T36987产 地：中国大陆

  • T36860C22 Sphingomyelin (d18:1/22:0)；C22 Sphingomyelin (d18:1/22:0)C22 Sphingomyelin (d18:1/22:0)；C22 Sphi

    C22 Sphingomyelin is a naturally occurring form of sphingomyelin . Plasma levels of C22 sphingomyelin positively correlate with hepatic steatosis severity in patients with chronic hepatitis C virus (HCV). C22 Sphingomyelin levels are decreased in T-47D mammary epithelial cells and increased in MDA-MB-231 breast cancer cells relative to C16 sphingomyelin .

    价 格：￥电议型 号：T36860产 地：中国大陆

  • T36859C16 Globotriaosylceramide (d18:1/16:0)；C16 Globotriaosylceramide (d18:1/16:0)C16 Globotriaosylcerami

    C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien

    价 格：￥电议型 号：T36859产 地：中国大陆

  • T36858C12 Galactosylceramide (d18:1/12:0)；C12 Galactosylceramide (d18:1/12:0)C12 Galactosylceramide (d18:1

    C12 Galactosylceramide is a bioactive sphingolipid. It inhibits IL-4 production by 53.84% in EL4 T cells when used at a concentration of 10 μM. C12 Galactosylceramide reduces the growth of human papillomavirus type 16-associated tumors in mice and reduces tumor recurrence following surgical removal or chemotherapy. It also reduces natural killer T cell activity, delays the onset of proteinuria, and improves survival in a mouse model of systemic lupus.

    价 格：￥电议型 号：T36858产 地：中国大陆

  • T36324C8 L-threo Ceramide (d18:1/8:0)；C8 L-threo Ceramide (d18:1/8:0)C8 L-threo Ceramide (d18:1/8:0)；C8 L-

    C8 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 10 μM) and, like C8 D-threo ceramide , induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 L-erythro ceramide . C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~30 μg/ml.

    价 格：￥电议型 号：T36324产 地：中国大陆

  • T36323C8 Galactosylceramide (d18:1/8:0)；C8 Galactosylceramide (d18:1/8:0)C8 Galactosylceramide (d18:1/8:0)

    C8 Galactosylceramide is a synthetic C8 short-chain derivative of known membrane microdomain-forming sphingolipids. It increases the amount delivered and toxicity of doxorubicin in cancerous but not non-cancerous cells when incorporated into the nanoliposomal membrane of nanoliposomal-doxorubicin. C8 Galactosylceramide induces proliferation and cytokine production by splenocytes in vitro at concentrations ranging from 100-1,000 ng/ml but has no effect on natural killer T cell production in vivo.

    价 格：￥电议型 号：T36323产 地：中国大陆

  • T36322C8 D-threo Ceramide (d18:1/8:0)；C8 D-threo Ceramide (d18:1/8:0)C8 D-threo Ceramide (d18:1/8:0)；C8 D-

    C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein r

    价 格：￥电议型 号：T36322产 地：中国大陆

  • T36320C6 L-threo Ceramide (d18:1/6:0)；C6 L-threo Ceramide (d18:1/6:0)C6 L-threo Ceramide (d18:1/6:0)；C6 L-

    C6 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides., C6 L-threo Ceramide is cytotoxic to U937 cells in vitro (IC50 = 18 μM). It is metabolically inactive and, unlike C6 L-erythro ceramide , C6 L-threo ceramide cannot be converted to C6 glucosylceramide by ceramide glucosyltransferase. C6 L-threo Ceramide enhances IL-4 production induced by phorbol 12-myristate 13-acetate in EL4 T cells when used at a concentration of 10 μM.

    价 格：￥电议型 号：T36320产 地：中国大陆

  • T36319C6 L-erythro Ceramide (d18:1/6:0)；C6 L-erythro Ceramide (d18:1/6:0)C6 L-erythro Ceramide (d18:1/6:0)

    C6 L-erythro Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is metabolized by ceramide glucosyltransferase to form C6 L-erythro glucosylceramide. C6 L-erythro Ceramide is cytotoxic to U937 cells (IC50 = 18 μM).

    价 格：￥电议型 号：T36319产 地：中国大陆

  • T3614913C C16 Sphingomyelin (d18:1/16:0)；13C C16 Sphingomyelin (d18:1/16:0)13C C16 Sphingomyelin (d18:1/16

    13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in or

    价 格：￥电议型 号：T36149产 地：中国大陆

  • T36140BODIPY-C12 Ceramide (d18:1/12:0)；BODIPY-C12 Ceramide (d18:1/12:0)BODIPY-C12 Ceramide (d18:1/12:0)；BO

    BODIPY-C12 Ceramide (B12Cer) is a fluorescently-tagged form of C12 ceramide, with excitation/emission maxima at 505/540 nm, respectively. It is a fluorescently-labeled sphingolipid and has been utilized for quantifying acid sphingomyelinase activity in the plasma of patients with Niemann-Pick disease.

    价 格：￥电议型 号：T36140产 地：中国大陆

  • T35927C2 L-threo Ceramide (d18:1/2:0)；C2 L-threo Ceramide (d18:1/2:0)C2 L-threo Ceramide (d18:1/2:0)；C2 L-

    C2 L-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 μM, however, this efflux is 50% less than that stimulated by C2 ceramide . C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 μM. It also induces cell cycle arrest in the G0/G1

    价 格：￥电议型 号：T35927产 地：中国大陆

  • T35873C19 Ceramide (d18:1/19:0)；C19 Ceramide (d18:1/19:0)C19 Ceramide (d18:1/19:0)；C19 Ceramide (d18:1/19:

    C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3]

    价 格：￥电议型 号：T35873产 地：中国大陆

  • T35810C24 dihydro Ceramide (d18:0/24:0)；C24 dihydro Ceramide (d18:0/24:0)Cer(d18:0/24:0)；Cer(d18:0/24:0)

    C24 dihydro Ceramide is a sphingolipid that has been found in the stratum corneum of human skin.[1] It is found in higher concentrations in female sebum compared to male sebum.[2] C24 dihydro Ceramide levels positively correlate with cytotoxicity in CCRF-CEM, MOLT-4, COG-LL-317h, and COG-LL-332h T cell acute lymphoblastic leukemia (ALL) cell lines.[4] Levels of C24 dihydro ceramide are increased by 149.49-fold in dihydroceramide desaturase 1 (DEGS1) knockdown UM-SCC-22A human head and neck squam

    价 格：￥电议型 号：T35810产 地：中国大陆

  • T35809C20 Sphingomyelin (d18:1/20:0)；C20 Sphingomyelin (d18:1/20:0)C20 Sphingomyelin (d18:1/20:0)

    C20 Sphingomyelin is a naturally occurring sphingolipid. Levels of C20 sphingomyelin are upregulated in the hippocampus of rats with diabetes induced by streptozotocin and in human plasma where it is positively correlated with insulin resistance in obese humans. C20 sphingomyelin is also upregulated in the liver of a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. The plasma concentration of C20 sphingomyelin is decreased in m

    价 格：￥电议型 号：T35809产 地：中国大陆

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