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T76787Conatumumab；西他土珠TRAIL-R2 mAb|||AMG 655；TRAIL-R2 mAb|||AMG 655
Conatumumab (AMG 655) is a monoclonal agonist antibody targeting human death receptor 5 (DR5, TRAILR2) at Kd 1 nM for long DR5 and Kd 0.8 nM for short DR5. Conatumumab induces apoptosis in a variety of tumor types through caspase activation. Conatumumab can be used to study advanced solid tumors.
价 格：￥电议型 号：T76787产 地：中国大陆
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T76779Brodalumab；布罗利尤单抗LP 0160|||KHK-4827|||AMG-827；LP 0160|||KHK-4827|||AMG-827
Brodalumab (AMG 827) is a human monoclonal antibody targeting interleukin 17 receptor (IL-17R) IgG2, often used as an immunosuppressant in the treatment of psoriasis and psoriasis.
价 格：￥电议型 号：T76779产 地：中国大陆
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T76758Rilotumumab；利妥木单抗AMG 102；AMG 102
Rilotumumab (AMG 102) is a monoclonal antibody targeting hepatocyte growth factor that inhibits HGF/ MET-driven signaling. Rilotumumab has antitumor effects and can be used to study castration-resistant prostate cancer (CRPC) and gastric cancer.
价 格：￥电议型 号：T76758产 地：中国大陆
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T7189AMG9810化合物AMG9810(2E)-N-(2,3-二氢-1,4-苯并二噁英-6-基)-3-[4-(1,1-二甲基乙基)苯基]-2-丙酰胺
AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively).
价 格：￥电议型 号：T7189产 地：中国大陆
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T71736AMG-628, (R)-；化合物 AMG-628, (R)-AMG-628, (R)-
AMG-628, (R)- is the R isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. AMG-628 has shown to inhibit growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
价 格：￥电议型 号：T71736产 地：中国大陆
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T71354AMG-222 tosylate；化合物 AMG-222 tosylateAMG-222 tosylate
AMG-222 tosylate is a DPP-IV inhibitor in clinical development for type II diabetes.
价 格：￥电议型 号：T71354产 地：中国大陆
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T7123AMG-47a；化合物AMG-47aAMG-47a
AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
价 格：￥电议型 号：T7123产 地：中国大陆
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T70391AMG151 HCl；化合物 AMG151 HClAMG151 HCl
ARRY-403, also known as AMG-151, is an orally available allosteric glucokinase (GK) activator developed for the treatment of type 2 diabetes mellitus (T2DM). ARRY-403 has many favorable physicochemical characteristics and ADME properties (low potential to cause drug–drug interactions (DDIs). ARRY-403 potently activates human glucokinase (GK) in vitro (EC50 = 79 nM at 5 mM glucose), with an S0.5 = 0.93 mM glucose (ARRY-403 at 5 mM) and Vmax = 134% compared to the no activator control. It possesse
价 格：￥电议型 号：T70391产 地：中国大陆
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T70318AMG-337 monohydrate；化合物 AMG-337 monohydrateAMG-337 monohydrate
AMG-337 monohydrate is a highly selective small molecule MET inhibitor. Aberrant hepatocyte growth factor (HGF)/MET signaling has been implicated in hepatocarcinogenesis, suggesting that MET may serve as an attractive therapeutic target in hepatocellular carcinoma.
价 格：￥电议型 号：T70318产 地：中国大陆
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T69740AMG-315；化合物 AMG-315AMG-315
AMG-315 is a Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes. AMG-315 is a chiral arachidonoyl ethanolamide (AEA) analogue or (13S,1′R)-dimethylanandamide. AMG-315 is a high affinity ligand for the CB1 receptor (Ki of 7.8 ± 1.4 nM) that behaves as a potent CB1 agonist in vitro (EC50 = 0.6 ± 0.2 nM). AMG-315 is the first potent AEA analogue with significant stability for all endocannabinoid hydrolyzing enzymes as well as the oxidative enzymes COX-2. AMG-315 will serve as a
价 格：￥电议型 号：T69740产 地：中国大陆
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T68850AMG-076 free base；化合物 AMG-076 free baseAMG-076 free base
AMG-076 free base is a potent and selective MCHR1 antagonist.
价 格：￥电议型 号：T68850产 地：中国大陆
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T68567AMG-131 besylate；化合物 AMG-131 besylateAMG-131 besylate
AMG-131 besylate is a hypoglycemic agent. It is a potent PPARγ partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs.
价 格：￥电议型 号：T68567产 地：中国大陆
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T68523AMG-628, (S)-；化合物 AMG-628, (S)-AMG-628, (S)-
AMG-628, (S)-, is the S isomer of AMG-628 --- a potent, ATP-competitive inhibitor of Raf kinases. AMG-628 displays selectivity for Raf kinases and inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. AMG-628 has shown to inhibit growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
价 格：￥电议型 号：T68523产 地：中国大陆
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T68408AMG-1；化合物 AMG-1AMG-1
AMG-1 is a specific CRAC channel inhibitor. AMG-1 blocks the function of effector T cells, but not regulatory T cells in vitro and it attenuates the progression and severity of EAE in vivo.
价 格：￥电议型 号：T68408产 地：中国大陆
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T6757AMG319；化合物AMG319AMG319
AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.
价 格：￥电议型 号：T6757产 地：中国大陆
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T6756AMG 925；化合物AMG 925AMG 925
AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.
价 格：￥电议型 号：T6756产 地：中国大陆
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T6384Ammonium Glycyrrhizinate；甘草酸单铵盐Glycyram|||Glycamil|||AMGZ；Glycyram|||甘草酸单铵盐|||Glycamil|||AMGZ
Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.
价 格：￥电议型 号：T6384产 地：中国大陆
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T6380AMG 900；莪术醇.姜黄醇AMG900|||AMG-900；AMG900|||AMG-900|||莪术醇.姜黄醇
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.
价 格：￥电议型 号：T6380产 地：中国大陆
