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T22256c-Kit-IN-5-1；化合物AMG-253-(2-Aminoquinazolin-6-yl)-4-methyl-1-(4-(oxazol-2-yl)phenyl)pyridin-2(1H)-one
c-Kit-IN-5-1 (AMG-25) is a novel selective and potent c-Kit inhibitor.
价 格：￥电议型 号：T22256产 地：中国大陆
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T17232Vidupiprant；化合物VidupiprantAMG 853；AMG 853
Vidupiprant (AMG 853) is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.
价 格：￥电议型 号：T17232产 地：中国大陆
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T17096Tilapertin；化合物 T17096AMG747；AMG747
Tilapertin is an oral glycine transporter type-1 inhibitor.
价 格：￥电议型 号：T17096产 地：中国大陆
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T14390Azelaprag；化合物AzelapragAMG 986；AMG 986
Azelaprag (AMG 986) is an effective small-molecule apelin receptor agonist. Azelaprag can be used to treat neurological diseases and cardiovascular diseases.
价 格：￥电议型 号：T14390产 地：中国大陆
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T14217AMG 579；化合物AMG 579AMG-579；AMG-579
AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).
价 格：￥电议型 号：T14217产 地：中国大陆
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T14216AMG 837；化合物 T14216AMG 837
AMG 837 is a partial GPR40 agonist with an EC50 value of 13 nM, showcasing 85% of the maximal activity displayed by DHA in standard assay conditions, indicating its high potency and selectivity in vitro. This compound excels as a GPR40 agonist with a notable pharmacokinetic profile, effectively stimulating insulin secretion in a glucose-dependent manner in rodents and demonstrating potent insulin secretion stimulation in MIN6 cells, with efficacy comparable to that observed in aequorin Ca2+-flux
价 格：￥电议型 号：T14216产 地：中国大陆
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T14215AMG 837 sodium salt；化合物 T14215AMG 837 sodium salt
AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50 = 23 and 13 nM, respectively). AMG 837 is a highly potent stimulator of insulin secr
价 格：￥电议型 号：T14215产 地：中国大陆
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T14214AMG 511；化合物AMG 511AMG 511
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease.
价 格：￥电议型 号：T14214产 地：中国大陆
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T14213Tapotoclax；化合物 T14213AMG-176；AMG-176
AMG-176 is a MCL-1 inhibitor (Ki: 0.13 nM).
价 格：￥电议型 号：T14213产 地：中国大陆
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T14212AMG-1694；化合物AMG-1694AMG-1694
AMG-1694, a potent disruptor of the glucokinase–glucokinase regulatory protein (GK-GKRP) complex, operates by promoting the dissociation of this complex, thereby indirectly enhancing GK enzymatic activity with an IC50 of 7 nM. It effectively normalizes blood glucose levels in various rodent diabetes models [1] and lowers blood glucose specifically in diabetic animals without affecting normoglycemic ones. Additionally, AMG-1694 reverses the GKRP-induced inhibition of GK activity and facilitates G
价 格：￥电议型 号：T14212产 地：中国大陆
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T14211AMG-009；化合物 T14211AMG009|||AMG 009|||AMG009|||AMG-009|||AMG 009；AMG009|||AMG 009|||AMG009|||AMG-009|
AMG-009 is a prostaglandin D2 antagonist. For CRTH2 and DP receptors, the IC50s are 3 nM and 12 nM, respectively.
价 格：￥电议型 号：T14211产 地：中国大陆
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T12655(Rac)-AMG8379；化合物(Rac)-AMG8379(Rac)-AMG8380；(Rac)-AMG8380
(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.
价 格：￥电议型 号：T12655产 地：中国大陆
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T125241Griffithinam；化合物 GriffithinamGriffithinam
Griffithinam is a useful organic compound for research related to life sciences and the catalog number is T125241.
价 格：￥电议型 号：T125241产 地：中国大陆
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T124497Tamgermanetin；化合物 TamgermanetinTamgermanetin
Tamgermanetin is a useful organic compound for research related to life sciences and the catalog number is T124497.
价 格：￥电议型 号：T124497产 地：中国大陆
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T11762LKira8；化合物Kira8AMG-18；AMG-18
Kira8 (AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity (IC50: 5.9 nM).
价 格：￥电议型 号：T11762L产 地：中国大陆
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T11762Kira8 Hydrochloride；化合物 T11762AMG-18 Hydrochloride；AMG-18 Hydrochloride
Kira8 Hydrochloride is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
价 格：￥电议型 号：T11762产 地：中国大陆
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T10317Raleukin；阿那白滞素AMG-719|||Anakinra；AMG-719|||阿那白滞素|||Anakinra
Anakinra (Raleukin) is an antagonist of recombinant, nonglycosylated human IL-1R. It is the first biological agent to block the pro-inflammatory effects.
价 格：￥电议型 号：T10317产 地：中国大陆
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T10300AMG2850；化合物AMG2850AMG2850
AMG2850 is a potent, orally bioavailable, and selective antagonist of transient receptor potential melastatin 8 (TRPM8).
价 格：￥电议型 号：T10300产 地：中国大陆
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T10299AMG PERK 44；化合物 AMG PERK 44AMG PERK 44
AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) that induces autophagy.AMG PERK 44 inhibits GCN2 (IC50: 7300 nM) and B-Raf (IC50 >1000 nM) and can be used in the study of cancer.
价 格：￥电议型 号：T10299产 地：中国大陆
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T10298L2AMG-548 dihydrochloride (864249-60-5 free base)；化合物 T10298L2AMG-548 dihydrochloride；AMG-548 dihydroc
AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50: 3 nM).
价 格：￥电议型 号：T10298L2产 地：中国大陆
