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T70403VUF14480;化合物 VUF14480VUF14480
VUF14480 is a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H? receptor. VUF14480 was shown to be a partial agonist of hH4 receptor-mediated G protein signalling and β-arrestin2 recruitment. VUF14480 bound covalently to the hH? receptor with submicromolar affinity. Serine substitution of C98(3.36) prevented this covalent interaction.
价 格:¥电议型 号:T70403产 地:中国大陆
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T69921BRF110;化合物 BRF110BRF110
BRF110 is a brain penetrant, potent and selective agonist of nuclear receptor-related 1 (Nurr1):Retinoid X receptor α (RXRα) heterodimer. BRF110 is a neuroprotective agent that prevents dopaminergic neuron demise and striatal dopaminergic denervation in vivo against PD-causing toxins. It induced dopamine biosynthesis in vivo. BRF110 chronic dosing does not induce dyskinesia in mice model.
价 格:¥电议型 号:T69921产 地:中国大陆
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T69775VUF14862;化合物 VUF14862VUF14862
VUF14862 is a robust and fatigue-resistant photoswitchable GPCR antagonist.
价 格:¥电议型 号:T69775产 地:中国大陆
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T69774VUF14738;化合物 VUF14738VUF14738
VUF14738 is a robust and fatigue-resistant photoswitchable GPCR antagonist.
价 格:¥电议型 号:T69774产 地:中国大陆
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T69654VUF16839;化合物 VUF16839VUF16839
VUF16839 is a high-affinity non-imidazole histamine H3 receptor agonist.
价 格:¥电议型 号:T69654产 地:中国大陆
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T68499F15845 HBr;化合物 F15845 HBrF15845 HBr
F 15845 is a blocker of the persistent sodium current prevents consequences of hypoxia in rat femoral artery. F15845 has been shown to selectively inhibit the persistent sodium current of Nav1.5[1] exerting cardioprotective effects following ischemia. In vitro testing showed minimal effects of F15845 on other important ion channels of the heart, including major Ca2+ and K+ channels.[1] This characteristic is thought to account for the limited effect of F15845 to change other heart parameters suc
价 格:¥电议型 号:T68499产 地:中国大陆
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T68058Dulozafone;度氯扎封F1933;F1933
Dulozafone (F1933) has an anti- showed anticonvulsant activity in a brain amygdala ignition model and protected fully ignited rats from generalized seizures.
价 格:¥电议型 号:T68058产 地:中国大陆
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T67837(3S)-GSK-F1;化合物 GSK-F1PI4KA inhibitor-F1;PI4KA inhibitor-F1
(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4?Kinase Alpha (PI4KIIIα), pIC50=8.3.
价 格:¥电议型 号:T67837产 地:中国大陆
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T6682STF-118804;化合物STF118804STF 118804|||STF118804;STF 118804|||STF118804
STF-118804 is a highly specific NAMPT inhibitor; reduces the viability of most B-ALL cell lines with IC50 <10 nM.
价 格:¥电议型 号:T6682产 地:中国大陆
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T6667SF1670;化合物SF1670PTP CD45 Inhibitor|||PTPase CD45 Inhibitor;PTP CD45 Inhibitor|||PTPase CD45 Inhibito
SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.
价 格:¥电议型 号:T6667产 地:中国大陆
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T66657VUF11207 trifluoroacetate salt;化合物 VUF11207 trifluoroacetate saltVUF11207 trifluoroacetate salt
VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.
价 格:¥电议型 号:T66657产 地:中国大陆
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T6525GW 5074化合物GW5074GW5074|||3-(3,5-二溴-4-羟基苯亚甲基)-5-碘-1,3-二氢吲哚-2-酮|||Raf1 Kinase Inhibitor I
GW 5074 (Raf1 Kinase Inhibitor I)(IC50=9 nM) is an effective and specific c-Raf inhibitor. It has no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms.
价 格:¥电议型 号:T6525产 地:中国大陆
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T6513Bisindolylmaleimide I;化合物Bisindolylmaleimide IGF109203X|||Go 6850;GF109203X|||Go 6850|||3-[1-[3-(二甲氨
Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.
价 格:¥电议型 号:T6513产 地:中国大陆
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T64068KIF18A-IN-3;化合物 KIF18A-IN-3KIF18A-IN-3
KIF18A-IN-3 is a potent inhibitor of KIF18A with an IC50 value of 61 nM. KIF18A-IN-3 significantly causes mitotic arrest and increases the number of mitotic cells in tumour tissue. kIF18A-IN-3 can be used to study tumours.
价 格:¥电议型 号:T64068产 地:中国大陆
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T64066CSF1R-IN-3;化合物CSF1R-IN-3CSF1R-IN-3
CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1R-IN-3 exhibits anti-tumour effects and immune enhancing effects by inhibiting the migration of macrophages and inducing the reprogramming of M2-type macrophages to M1-type macrophages, thus exhibited activity against colorectal cancer cells.
价 格:¥电议型 号:T64066产 地:中国大陆
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T62851SLF1081851 TFA;化合物 SLF1081851 TFASLF1081851 TFA
SLF1081851 (TFA) is a Spns2 inhibitor with an IC50 value of 1.93 μM for inhibition of S1P release.SLF1081851 (TFA) plays a key role in development and the immune system.
价 格:¥电议型 号:T62851产 地:中国大陆
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T62557CSF1R-IN-14;化合物 CSF1R-IN-14CSF1R-IN-14
CSF1R-IN-14, an isoindolinone derivative compound, is a potent inhibitor of CSF1R. CSF1R-IN-14 has potential for cancer disease research.
价 格:¥电议型 号:T62557产 地:中国大陆
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T62390CSF1R-IN-8;化合物 CSF1R-IN-8CSF1R-IN-8
CSF1R-IN-8 (Compound 22) is a CSF-1R inhibitor (IC50: 0.012 μM).
价 格:¥电议型 号:T62390产 地:中国大陆
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T62364CSF1R-IN-5;化合物 CSF1R-IN-5CSF1R-IN-5
CSF1R-IN-5 is a potent inhibitor of CSF1R. CSF1R-IN-5 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-5 has the potential to be used in the study of cancer diseases.
价 格:¥电议型 号:T62364产 地:中国大陆
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T62342CSF1R-IN-4;化合物 CSF1R-IN-4CSF1R-IN-4
CSF1R-IN-4 is a potent inhibitor of CSF-1R. CSF1R-IN-4 can affect the exchange of inflammatory factors between TAM and glioma cells. CSF1R-IN-4 has potential for the study of cancer diseases. EGFR-IN-40.
价 格:¥电议型 号:T62342产 地:中国大陆