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  • T62304Minzasolmin;化合物Minzasolmin(R)-NPT200-11|||UCB0599|||DLX-313;(R)-NPT200-11|||UCB0599|||DLX-313

    Minzasolmin(DLX-313) is an alpha-synuclein misfolding inhibitor for the study of Parkinson´s disease.

    价 格:¥电议型 号:T62304产 地:中国大陆

  • T60976Bezuclastinib;化合物BezuclastinibCGT9486|||PLX 9486;CGT9486|||PLX 9486

    Bezuclastinib (CGT9486) is a novel, potent and highly selective tyrosine kinase and c-kit D816V inhibitor for the study of advanced mastocytosis.

    价 格:¥电议型 号:T60976产 地:中国大陆

  • T6044Telotristat Etiprate;特罗司他马尿酸盐LX1606 (Hippurate)|||LX 1606 Hippurate;LX1606 (Hippurate)|||LX 1606 Hip

    Telotristat Etiprate (LX 1606 Hippurate) is an orally bioavailable, tryptophan hydroxylase (TPH) inhibitor with potential antiserotonergic activity.

    价 格:¥电议型 号:T6044产 地:中国大陆

  • T5600Darovasertib;化合物LXS196LXS196;LXS196

    Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor(IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively).

    价 格:¥电议型 号:T5600产 地:中国大陆

  • T5317LCridanimod sodium;化合物 T5317LXBIO-101|||XBIO 101|||Cycloferon|||Sodium Cridanimod|||Cridanimod Na|||X

    Cridanimod can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen released from the ovaries.

    价 格:¥电议型 号:T5317L产 地:中国大陆

  • T4973Paraxanthine1,7-二甲基黄嘌呤1,7-二甲基黄嘌呤|||1,7-DIMETHYLXANTHINE

    Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is structurally similar to caffeine and possibly mediates the physiological effects of caffeine. Also Paraxanthine acts as a competitive phosphodiesterase inhibitor, which increases intracellular cAMP, activates PKA, inhibits TNF-α and leukotriene synthesis. In addition, Paraxanthine act

    价 格:¥电议型 号:T4973产 地:中国大陆

  • T47001,3,5-Trihydroxy-4-prenylxanthone;化合物 T47001,3,5-Trihydroxy-4-prenylxanthone

    1,3,5-Trihydroxy-4-prenylxanthone is a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC50 value of 3.0 μM; it shows in vitro inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 56.3plusmn;0.4 and 46.0plusmn;0.3 M, respectively. 1,3,5-Trihydroxy-4-prenylxanthone inhibits LPS-induced NF-κB and AP-1 activations by interfering with the posttranslational modification (phosphorylation and/or ubiquitinylation) of IRAK-1

    价 格:¥电议型 号:T4700产 地:中国大陆

  • T4398LX2343;化合物LX2343LX2343

    LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX2343 stimulates autophagy in its promotion of Aβ clearance.

    价 格:¥电议型 号:T4398产 地:中国大陆

  • T4067VLX1570;化合物VLX1570VLX1570

    VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.

    价 格:¥电议型 号:T4067产 地:中国大陆

  • T39740Acoramidis hydrochloride;盐酸橡酰胺AG10 hydrochloride|||Alxn2060 hydrochloride;AG10 hydrochloride|||Alxn2

    Acoramidis hydrochloride (Alxn2060 hydrochloride) is an orally active and selective kinetic stabilizer of WT and V122I- TTR (transthyretin) . Acoramidis hydrochloride is used in the study for transthyretin amyloidosis.

    价 格:¥电议型 号:T39740产 地:中国大陆

  • T39555Belumosudil mesylateBelumosudil mesylateSLx-2119mesylate|||KD025 mesylate

    Belumosudil mesylate (KD025 mesylate) is a compound that selectively inhibits ROCK2, demonstrating IC50 values of 105 nM for ROCK2 and 24 μM for ROCK1. It possesses anti-fibrotic properties.

    价 格:¥电议型 号:T39555产 地:中国大陆

  • T39493VemircopanVemircopanACH0145228|||ACH-5228|||ALXN2050

    Vemircopan is a complement factor D inhibitor.

    价 格:¥电议型 号:T39493产 地:中国大陆

  • T39214LLXE408 fumarate;化合物LXE408 fumarateLXE408 fumarate (1799330-15-6 Free base);LXE408 fumarate (1799330-

    LXE408 fumarate is an orally active, non-competitive and kinetoplastid-selective?proteasome?inhibitor. LXE408 fumarate has an?IC50?of 0.04 μM for?L. donovani?proteasome and an?EC50?of 0.04 μM for?L. donovani. LXE408 fumarate has a low propensity to cross the blood brain barrier. LXE408 fumarate has the potential for visceral leishmaniasis (VL) research.

    价 格:¥电议型 号:T39214L产 地:中国大陆

  • T39194PLX647 dihydrochloride;PLX647 dihydrochloridePLX647 dihydrochloride

    PLX647 dihydrochloride is a potent and selective dual inhibitor of FMS and KIT kinases, with IC50 values of 28 nM and 16 nM, respectively. At a concentration of 1 μM, PLX647 dihydrochloride demonstrates superior selectivity against a wide range of 400 kinases, except FLT3 and KDR, where IC50 values are 91 nM and 130 nM, respectively. This orally active compound holds great potential for targeted kinase inhibition.

    价 格:¥电议型 号:T39194产 地:中国大陆

  • T38495Gypenoside LXXV;绞股蓝皂苷LXXVGypenoside LXXV

    Gypenoside LXXV, derived from Gynostemma pentaphyllum, is a deglycosylated form of ginsenoside Rb1. This compound effectively decreases cancer cell viability and exhibits potent anti-cancer properties.

    价 格:¥电议型 号:T38495产 地:中国大陆

  • T37273BLX3887;BLX3887BLX3887

    BLX3887 is an inhibitor of 15-lipoxygenase type 1 (15-LO-1; IC50 = 32 nM in a cell-free enzyme assay).1 It is selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM), and 12-LO (IC50 = 3,310 nM). BLX3887 inhibits the production of 15-LO metabolites selectively in eosinophils over neutrophils when used at a concentration of 10 μM. It also inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro.

    价 格:¥电议型 号:T37273产 地:中国大陆

  • T36404LPRLX-93936 HCL;化合物 PRLX-93936 hclPRLX-93936 hcl(903499-49-0 Free base);PRLX-93936 hcl(903499-49-0 Fr

    PRLX-93936 HCL is an analog of erastin and demonstrated synergistic effects against non-small cell lung cancer (NSCLC) cells with cisplatin.

    价 格:¥电议型 号:T36404L产 地:中国大陆

  • T36404PRLX-93936;PRLX-93936PRLX-93936

    PRLX-93936 is an analog of erastin that has antitumor activity. It inhibits the hypoxia-inducible factor 1 (HIF-1) signaling pathway under hypoxic conditions (IC50 = 0.09 μM in a cell-based reporter assay). PRLX-93936 (1 μM) also inhibits hypoxia-induced increases in HIF-1α expression in ME-180 cervical cancer cells. It inhibits the growth of HT-1080 fibrosarcoma, OVCAR-5 ovarian cancer, BJELR tumorigenic primary fibroblast, and PANC-1 pancreatic cancer cells with IC50 values of less than 100 nM

    价 格:¥电议型 号:T36404产 地:中国大陆

  • T36275xStAx-VHLL;xStAx-VHLLxStAx-VHLL

    Selective peptide-based β-catenin Degrader. Comprises a β-catenin-targeted stapled peptide, xStAx, linked to a VHL-binding peptide. Reduces β-catenin levels in HEK293T cells and colorectal cancer cell lines. Selectively degrades β-catenin over other Wnt signaling pathway components. Inhibits tumor growth in APCmin/+ mice, with constitutively active Wnt signaling, and reduces survival of patient-derived colorectal cancer cell organoids.

    价 格:¥电议型 号:T36275产 地:中国大陆

  • T36052Lipoxin A4 methyl ester;Lipoxin A4 methyl esterLXA4 methyl ester;LXA4 methyl ester

    Lipoxin A4 methyl ester (LXA4 methyl ester) is a more lipid soluble, prodrug formulation of the transcellular metabolite LXA4. LXA4 is a trihydroxy fatty acid containing a conjugated tetraene, produced by the metabolism of 15-HETE or 15-HpETE with human leukocytes.[1] LXA4 is equipotent to leukotriene B4 (LTB4) in inducing superoxide generation in human neutrophils at 0.1 μM.[2] LXA4 is associated with several other biological functions including leukocyte activation, chemotaxis effects, natural

    价 格:¥电议型 号:T36052产 地:中国大陆

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