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T1595NevirapineNevirapine,NSC 641530,NVP
Nevirapine is a benzodiazepine non-nucleoside reverse transcriptase inhibitor. In combination with other antiretroviral drugs, nevirapine reduces HIV viral loads and increases CD4 counts, thereby retarding or preventing the damage to the immune system and
价 格:¥电议型 号:T1595产 地:美洲
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T16153MS4078MS4078
MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC. It has a Kd of 19?nM for binding affinity to ALK.
价 格:¥电议型 号:T16153产 地:美洲
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T1761PD153035 hydrochloridePD153035 hydrochloride,AG 1517,SU 5271
PD153035 hydrochloride (ZM 252868; AG 1517) is a effective and selective inhibitor of EGFR (Ki: 5.2 pM, IC50: 29 pM); few influence against FGFR, PGDFR, InsR, CSF-1, and Src.
价 格:¥电议型 号:T1761产 地:美洲
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T2041PD153035PD153035,AG1517,NSC 669364
PD153035 hydrochloride is an effective and selective inhibitor of EGFR (Ki/IC50: 5.2/29 pM, in cell-free assays); little inhibitory against FGFR, PGDFR, InsR, CSF-1 and Src.
价 格:¥电议型 号:T2041产 地:美洲
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T21531 nM-PP11 nM-PP1,PP1 Analog II,
1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.
价 格:¥电议型 号:T2153产 地:美洲
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T2380BIBR 1532BIBR 1532
BIBR 1532 is an effective, specific and non-competitive telomerase inhibitor (IC50: 100 nM, in a cell-free assay).
价 格:¥电议型 号:T2380产 地:美洲
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T5153Apatinib mesylateApatinib mesylate,Apatinib,YN968D1
Apatinib is an orally bioavailable and specific VEGFR2 inhibitor (IC50: 1 nM). In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.
价 格:¥电议型 号:T5153产 地:美洲
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T5S1530Isochlorogenic acid CIsochlorogenic acid C
1. Isochlorogenic acid C has antioxidant activity.
价 格:¥电议型 号:T5S1530产 地:美洲
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T6153IcotinibIcotinib,BPI-2009,BPI-2009H
Icotinib is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity.
价 格:¥电议型 号:T6153产 地:美洲
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T83867UNC8153 TFA;化合物 UNC8153 TFAUNC8153 TFA
UNC8153 is a NSD2-specific histone-lysine N-methyltransferase degrader, showing selective activity towards NSD2 over NSD1 and NSD3 at 20 ?M, and demonstrating a 50% degradation constant (DC50) of 350 nM. At a concentration of 10 ?M, UNC8153 induces NSD2 degradation and significantly diminishes histone H3 lysine 36 dimethylation (H3K36me2) levels in MM.1S multiple myeloma cells. This degradation effect can be blocked by MLN4924, an inhibitor of the ubiquitin-activating enzyme. Furthermore, UNC815
价 格:¥电议型 号:T83867产 地:中国大陆
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T83698Cathelicidin-2 (128-153) (chicken) TFA;化合物 Cathelicidin-2 (128-153) (chicken) TFAFowlicidin-2 (128-1
Cathelicidin-2 (CATH-2) (128-153) is a synthetic antimicrobial peptide derived from amino acids 128-153 of chicken CATH-2, demonstrating activity against pathogens such as E. coli, S. aureus, S. enteritidis, and B. globigii in a dose-dependent manner. At a concentration of 40 ?M, it induces hemolysis in chicken erythrocytes without exhibiting cytotoxicity towards human peripheral blood mononuclear cells (PBMCs). Additionally, it stimulates the production of the chemokine CCL2 and suppresses LPS-
价 格:¥电议型 号:T83698产 地:中国大陆
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T83153AH13;化合物 AH13AH13
AH13, a bi-phenylethylchromone, is extracted from the acetone extract of agarwood originating from Kalimantan [1].
价 格:¥电议型 号:T83153产 地:中国大陆
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T82153Huzhangoside C;化合物 Huzhangoside CHuzhangoside C
Huzhangoside C, an oleanane-type triterpenoid saponin, is extracted from the roots of Clematis argentilucida [1].
价 格:¥电议型 号:T82153产 地:中国大陆
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T82007JH-131e-153;化合物 JH-131e-153JH-131e-153
JH-131e-153, a diacylglycerol (DAG)-lactone, serves as a small molecule activator for the C1 domain of Munc13-1, exhibiting an activation hierarchy of WT>I590≈R592A≈W588A. This compound’s C1 domain shares homology in sequence and structure with protein kinase C (PKC), and its activation preference follows the order of PKCα>Munc13-1>PKCε. JH-131e-153 is implicated in the modulation of neuronal processes and holds potential for research in neurodegenerative diseases [1].
价 格:¥电议型 号:T82007产 地:中国大陆
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T81539PAT1inh-B01;化合物 PAT1inh-B01PAT1inh-B01
PAT1inh-B01, a selective SLC26A6 inhibitor, impedes PAT1 (a Cl-/HCO3- exchanger) activity, with an IC50 of 350 nM, effectively inhibiting anion exchange. It also obstructs fluid absorption in the small intestine and is utilized in the study of small intestinal hyposecretory disorders [1].
价 格:¥电议型 号:T81539产 地:中国大陆
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T81538Patecibart;化合物 PatecibartPatecibart
Patecibart is a humanized immunoglobulin G4-kappa monoclonal antibody that functions as an antagonist to the endothelin receptor A (EDNRA).
价 格:¥电议型 号:T81538产 地:中国大陆
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T81537Paucimannose;化合物 PaucimannosePaucimannose
Paucimannose, a prevalent mannosidic N-glycoepitope found in invertebrates and plants, is also expressed in cancers [1].
价 格:¥电议型 号:T81537产 地:中国大陆
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T81536PB089;化合物 PB089PB089
PB089 is a drug-like molecule featuring a polyethylene glycol (PEG) unit and a cleavable linker connected to Exatecan [1].
价 格:¥电议型 号:T81536产 地:中国大陆
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T81535PCSK9-IN-20;化合物 PCSK9-IN-20PCSK9-IN-20
PCSK9-IN-20 (Compound 3i) is a PCSK9 inhibitor exhibiting an IC50 value of 3.96 ?M, shown to reduce PCSK9 and enhance LDLR protein levels in vitro [1].
价 格:¥电议型 号:T81535产 地:中国大陆
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T81534PDE11A4-IN-1;化合物 PDE11A4-IN-1PDE11A4-IN-1
PDE11A4-IN-1 (compound 23b) is a potent, selective inhibitor of PDE11A4, demonstrating an IC50 of 12 nM and exhibiting high selectivity against PDE1, PDE2, PDE7, PDE8, and PDE9 [1].
价 格:¥电议型 号:T81534产 地:中国大陆