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  • T75139TMX1；化合物 TMX1TMX1

    TMX1 is a molecular glue degrader that covalently targets BRD4. It selectively recruits DCAF16 to the BRD4 BD2 domain, leading to the degradation of BRD4 [1].

    价 格：￥电议型 号：T75139产 地：中国大陆

  • T75138Lipid 14；化合物 Lipid 14Lipid 14

    Lipid 14, a potent ionizable compound, is essential for synthesizing lipid nanoparticles (LNPs) [1].

    价 格：￥电议型 号：T75138产 地：中国大陆

  • T75137BAY-747；化合物 BAY-747BAY-747

    BAY-747 (BAY 1165747) is an orally administered, brain-penetrant compound that stimulates soluble guanylate cyclase (sGC). It effectively counteracts memory impairments induced by L-NAME and improves cognitive performance in rats during the object location task (OLT). Additionally, BAY-747 reduces blood pressure in conscious normotensive and spontaneously hypertensive rats (SHR) and enhances skeletal muscle function in the mdx/mTRG2 mouse model of Duchenne muscular dystrophy (DMD) [1] [2] [3].

    价 格：￥电议型 号：T75137产 地：中国大陆

  • T75136IRAK degrader-1；化合物 IRAK degrader-1IRAK degrader-1

    IRAK degrader-1 (example I-3) is a potent IRAK degrader [1] .

    价 格：￥电议型 号：T75136产 地：中国大陆

  • T75135FHD-609；化合物 FHD-609FHD-609

    FHD-609, an inhibitor and degrader of BRD9 (bromodomain-containing protein 9), targets the ncBAF complex and is useful for researching a broad spectrum of cancers with mutations in a BAF complex subunit. When used alongside Telomelysin or INO5401, FHD-609 could be effective in treating adrenocortical carcinoma (ACC) [1] [2].

    价 格：￥电议型 号：T75135产 地：中国大陆

  • T75134MC-GGFG-AM-(10Me-11F-Camptothecin)；化合物 MC-GGFG-AM-(10Me-11F-Camptothecin)MC-GGFG-AM-(10Me-11F-Campto

    MC-GGFG-AM-(10Me-11F-Camptothecin) acts as a linker-payload conjugate in the synthesis of ZW251, an antibody-drug conjugate (ADC) designed to target human GPC3. This ADC comprises a humanized IgG1 antibody attached to ZD06519, a novel camptothecin-based topoisomerase 1 inhibitor, through a maleimide-anchor and a cleavable glycyl glycyl phenylalanyl glycine (GGFG)-aminomethyl (AM) linker. ZW251 exhibits strong affinity for GPC3 in both human and cynomolgus monkey cells. It is characterized by rap

    价 格：￥电议型 号：T75134产 地：中国大陆

  • T75133NRX-0492；化合物 NRX-0492NRX-0492

    NRX-0492 is an orally administered compound that efficiently degrades Bruton´s tyrosine kinase (BTK) by catalyzing its ubiquitylation and subsequent proteasomal degradation, achieving half-maximal degradation concentrations (DC50) of ≤0.2 nM and 90% degradation concentrations (DC90) of ≤0.5 nM. Additionally, NRX-0492 suppresses B-cell receptor (BCR) signaling, transcriptional activities, and chemokine production by linking a noncovalent BTK-binding domain to Cereblon, an adaptor protein wi

    价 格：￥电议型 号：T75133产 地：中国大陆

  • T75132PKR activator 4；化合物 PKR activator 4PKR activator 4

    PKR activator 4 (example 7A), a potent activator of pyruvate kinase R (PKR), holds promise for blood disorder research [1].

    价 格：￥电议型 号：T75132产 地：中国大陆

  • T75131RMC-6291；化合物 RMC-6291RMC-6291

    RMC-6291 is an orally active and covalent inhibitor of KRAS G12C (ON) . RMC-6291 forms a tri-complex within tumor cells between KRAS G12C (ON) and cyclophilin A (CypA). Thus, RMC-6291 prevents KRAS G12C (ON) from signaling via steric blockade of RAS effector binding. RMC-6291 elicits deep and durable suppression on RAS pathway activity in KRAS G12C tumor models [1] .

    价 格：￥电议型 号：T75131产 地：中国大陆

  • T75130Glucocorticoid receptor agonist-1 phosphate Ala-Ala-Br；化合物 Glucocorticoid receptor agonist-1 phospha

    Glucocorticoid Receptor Agonist-1 Phosphate Ala-Ala-Br is a drug-linker conjugate for antibody-drug conjugates (ADCs), serving as a reaction reagent in the creation of anti-CD40 antibody agent conjugates [1].

    价 格：￥电议型 号：T75130产 地：中国大陆

  • T7513Protease-Activated Receptor-2, amide；蛋白酶活化的受体-2，酰胺SLIGKV-NH2；蛋白酶活化的受体-2，酰胺|||SLIGKV-NH2|||H-丝氨酰亮氨酰异亮

    Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)

    价 格：￥电议型 号：T7513产 地：中国大陆

  • T75129Luxdegalutamide；化合物LuxdegalutamideARV-766；ARV-766

    Luxdegalutamide (ARV-766) is an orally available and effective protein degrader of protein hydrolysis-targeted chimeras (PROTAC).Luxdegalutamide degrades the wild-type androgen receptor AR, as well as AR LBD mutants including those associated with the most prevalent pathogenic AR L702H, H875Y and T878A mutations.

    价 格：￥电议型 号：T75129产 地：中国大陆

  • T75128I-152；化合物 I-152I-152

    I-152, a conjugate of N-acetyl-cysteine (NAC) and cysteamine (MEA), activates NRF2 and ATF4 signaling pathways and exhibits anti-proliferative properties [1].

    价 格：￥电议型 号：T75128产 地：中国大陆

  • T75127CDK-IN-12；化合物 CDK-IN-12CDK-IN-12

    CDK-IN-12 (Example 20), a CDK inhibitor, effectively inhibits CDK4/6, demonstrating IC50 values below 20 nM [1].

    价 格：￥电议型 号：T75127产 地：中国大陆

  • T75126Enpp-1-IN-15；化合物 Enpp-1-IN-15Enpp-1-IN-15

    Compound 88a (Enpp-1-IN-15) is an inhibitor of Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (Enpp-1), exhibiting a Ki value of 0.00586 nM [1].

    价 格：￥电议型 号：T75126产 地：中国大陆

  • T75125ITK degrader 2；化合物 ITK degrader 2ITK degrader 2

    ITK Degrader 2 (Compound 30) functions as a modulator for targeted ubiquitination and serves as a molecule for targeted protein degradation, specifically degrading ITK [1].

    价 格：￥电议型 号：T75125产 地：中国大陆

  • T75124BTK-IN-24；化合物 BTK-IN-24BTK-IN-24

    BTK-IN-24 (compound 195) is a potent BTK inhibitor via a ubiquitin proteolytic pathway [1] .

    价 格：￥电议型 号：T75124产 地：中国大陆

  • T751225-Lipoxygenase-IN-3；化合物 5-Lipoxygenase-IN-35-Lipoxygenase-IN-3

    5-Lipoxygenase-IN-3 (Compound 14), with an IC50 of less than 1 μM, serves as an inhibitor of 5-Lipoxygenase. This compound is utilized in the research of inflammatory diseases, cancer, stroke, and Alzheimer´s disease [1].

    价 格：￥电议型 号：T75122产 地：中国大陆

  • T75121CDK7-IN-21；化合物 CDK7-IN-21CDK7-IN-21

    CDK7-IN-21 (compound A22) is a potent CDK7 inhibitor [1] .

    价 格：￥电议型 号：T75121产 地：中国大陆

  • T75120EGFR-IN-76；化合物EGFR-IN-76EGFR-IN-76

    EGFR-IN-76 is a potent EGFR inhibitor.

    价 格：￥电议型 号：T75120产 地：中国大陆

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