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T79372A3AR agonist 1;化合物 A3AR agonist 1A3AR agonist 1
A3AR Agonist 1 (Compound 12), with a Ki of 25.8 nM, is a potent A3 adenosine receptor (A3AR) agonist that promotes β-arrestin2 recruitment with an effective concentration (EC50) of 5.17 nM. It serves as a research tool in various pathological conditions, including inflammatory diseases, ischemia, cancer, neuropathic pain, and liver diseases [1].
价 格:¥电议型 号:T79372产 地:中国大陆
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T79343hCYP3A4-IN-1;化合物 hCYP3A4-IN-1hCYP3A4-IN-1
hCYP3A4-IN-1 (compound C6) is a potent, orally active inhibitor of hCYP3A4, exhibiting IC50 values of 43.93 nM in human liver microsomes (HLMs) and 153.00 nM in the CHO-3A4 stably transfected cell line. It competitively inhibits the CYP3A4-mediated hydroxylation of N-ethyl-1,8-naphthalimide (NEN) with a Ki of 30.00 nM [1].
价 格:¥电议型 号:T79343产 地:中国大陆
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T79331Antioxidant agent-13;化合物 Antioxidant agent-13Antioxidant agent-13
Compound 5f (Antioxidant agent-13) is an antioxidant that demonstrates inhibition of DPPH and FRAP with half maximal inhibitory concentrations (IC50s) of 80.33 ?M and 85.69 ?M, respectively. Additionally, it inhibits the enzymes lipoxygenase (LOX) and xanthine oxidase (XO) with IC50s of 16.85 ?M and 23.01 ?M, respectively [1].
价 格:¥电议型 号:T79331产 地:中国大陆
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T79267Antihypertensive agent 3;化合物 Antihypertensive agent 3Antihypertensive agent 3
Antihypertensive agent 3 (compound 4a), an angiotensin II receptor 1 antagonist, demonstrates antihypertensive activity in spontaneously hypertensive rats (SHRs) [1].
价 格:¥电议型 号:T79267产 地:中国大陆
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T79252Apoptosis inducer 13;化合物 Apoptosis inducer 13Apoptosis inducer 13
Apoptosis Inducer 13 (Compound Ru4) promotes apoptosis in cancer cells while also suppressing their migration and invasion. Additionally, it facilitates the conversion of coenzyme NADH to NAD+, and elevates intracellular ROS levels [1].
价 格:¥电议型 号:T79252产 地:中国大陆
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T79027A1/A3 AR antagonist 3;化合物 A1/A3 AR antagonist 3A1/A3 AR antagonist 3
A1/A3 AR Antagonist 3 is a dual A1R/A3R antagonist that demonstrates high affinity within the low-micromolar to nanomolar range, and is potentially useful in the research of chronic heart diseases [1].
价 格:¥电议型 号:T79027产 地:中国大陆
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T78978Antitrypanosomal agent 13;化合物 Antitrypanosomal agent 13Antitrypanosomal agent 13
Compound 4b (antitrypanosomal agent 13) is a potent antitrypanosomal with notable trypanocidal and cytotoxic activities, exhibiting GI50 values of 0.18 μM against T. brucei and 8.4 μM for HL-60 [1].
价 格:¥电议型 号:T78978产 地:中国大陆
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T78959ATR-IN-23;化合物 ATR-IN-23ATR-IN-23
ATR-IN-23 (Compound 34), a potent and selective ATR inhibitor, exhibits an IC50 of 1.5 nM, has demonstrated antiproliferative effects on LoVo cells, and induces synthetic lethality in HT-29 cells, suggesting its utility in researching DNA damage response (DDR)-deficient cancers [1].
价 格:¥电议型 号:T78959产 地:中国大陆
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T78912Antitumor agent-113;化合物 Antitumor agent-113Antitumor agent-113
Antitumor Agent-113 exhibits cytotoxicity in A549 cells, with an IC50 of 46.60 μM, and induces apoptosis, making it applicable for research in non-small cell lung cancer [1].
价 格:¥电议型 号:T78912产 地:中国大陆
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T78743Anticancer agent 133;化合物 Anticancer agent 133Anticancer agent 133
Compound Rh2 (Anticancer agent 133) is a cytotoxic and antimetastatic agent that induces cell cycle arrest, apoptosis, and autophagy. Additionally, it suppresses cell metastasis through the inhibition of EGFR expression, which is mediated by FAK-regulated integrin β1 [1].
价 格:¥电议型 号:T78743产 地:中国大陆
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T78560U-89843A;化合物 U-89843AU-89843A
U-89843A is an allosteric modulator of the GABA_A receptor, known to enhance GABA-induced Cl^- currents [1].
价 格:¥电议型 号:T78560产 地:中国大陆
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T7847Apelin-13 triTFA(217082-58-1(free base));人牛APELIN-13Apelin-13 triTFA(217082-58-1(free base))
Apelin-13 triTFA is the endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM.
价 格:¥电议型 号:T7847产 地:中国大陆
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T78451Patent Blue V;专利蓝VF ;酸性蓝1,食品蓝3;食品蓝 3Acid blue 1;Acid blue 1
Patent Blue V (Acid blue 1), a biological dye, serves as an intraocular stain in retinectomy—surgical removal of the inner limiting membrane (ILM). Its use facilitates the complete excision of premembrane structures in vitreoretinal surgeries. Spectral analysis reveals that Patent Blue V absorbs strongly below 450 nm and above 600 nm, exhibiting a blue-green hue. Additionally, it functions as a tracer in lymphangiography to guide the surgical removal of cancerous lymph nodes [1][2].
价 格:¥电议型 号:T78451产 地:中国大陆
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T78173Aβ/tau aggregation-IN-3;化合物 Aβ/tau aggregation-IN-3Aβ/tau aggregation-IN-3
Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 ?M in an Aβ-Thioflavin T (Aβ-ThT) functional aggregation assay. This compound demonstrates anti-amyloid activity [1].
价 格:¥电议型 号:T78173产 地:中国大陆
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T77887Amine-PEG3-Lys(PEG3-N3)-PEG3-N3;化合物 Amine-PEG3-Lys(PEG3-N3)-PEG3-N3Amine-PEG3-Lys(PEG3-N3)-PEG3-N3
Amine-PEG3-Lys(PEG3-N3)-PEG3-N3 (compound 5) is a branched linker utilized in antibody-drug conjugate (ADC) [1] synthesis.
价 格:¥电议型 号:T77887产 地:中国大陆
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T7780Blarcamesine;化合物AVex-73AE-37|||AVex-73;AE-37|||AVex-73
Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer´s disease.
价 格:¥电议型 号:T7780产 地:中国大陆
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T77698hCYP3A4 Fluorogenic substrate 1;化合物 hCYP3A4 Fluorogenic substrate 1hCYP3A4 Fluorogenic substrate 1
hCYP3A4 Fluorogenic substrate 1 is a phthalimide derivative and shows low activity against COX.
价 格:¥电议型 号:T77698产 地:中国大陆
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T77671GSK3a-IN-38;GSK3a抑制剂38GSK3a-IN-38
GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.
价 格:¥电议型 号:T77671产 地:中国大陆
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T77566(3aR,9aR)-Fluparoxan;化合物(3aR, 9aR)-Fluparoxan(3aR,9aR)-Fluparoxan
(3aR,9aR)-Fluparoxan is a highly selective and potent adrenergic receptor α2B antagonist for the prevention, amelioration or treatment of neurodevelopmental disorders and neurodegenerative diseases.
价 格:¥电议型 号:T77566产 地:中国大陆
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T7656Apelin-13;化合物Apelin-13Apelin-13
Apelin-13 is a 13-amino acid peptide sequence found in the central and peripheral nervous system that is an endogenous ligand for the G protein-coupled receptor angiotensin II protein J (APJ), with an EC50 value of 0.37 nM for APJ.Apelin-13 has vasodilatory and antihypertensive activity and can be used to study type 2 diabetic syndrome. Apelin-13 has vasodilatory and antihypertensive activities and can be used to study type 2 diabetes syndrome.
价 格:¥电议型 号:T7656产 地:中国大陆