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T7123AMG-47aInhibitor,signal,kinases,AMG 47a,JAK,Janus kinase,AMG-47a,transduction,Src,VEGFR,cytoplamic,p
AMG-47a is a potent inhibitor of Lck and T cell proliferation. AMG-47a could promote the degradation of the KRAS oncoprotein. AMG-47a selectively reduced the levels of EGFP-KRASG12V protein but did not affect EGFP protein in cells.
价 格：￥电议型 号：T7123产 地：中国大陆
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T8409SYN1143c-Met/HGFR,SYN-1143,tumor,RON,dual,inhibit,SYN1143,SYN 1143,cancer,Inhibitor,c-Met
AMG-1 is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.
价 格：￥电议型 号：T8409产 地：中国大陆
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T8403CinacalcetAMG-073,Calcium-sensing receptor,Endogenous Metabolite,Inhibitor,CaSR,Cinacalcet,inhibit,A
Cinacalcet is an orally active, allosteric Ca receptor (CaR) agonist, treatment of cardiovascular disease .
价 格：￥电议型 号：T8403产 地：中国大陆
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T6756AMG 925CDK,AMG 925,Cluster of differentiation antigen 135,FLT3,Cyclin dependent kinase,inhibit,CD135
AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.
价 格：￥电议型 号：T6756产 地：中国大陆
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T8684SotorasibAMG 510,Ras,KRAS,covalent,Sotorasib,regression,mutation,Inhibitor,G12C,anti-tumour,inhibit,
AMG-510 is a selective and orally bioavailable KRAS G12C covalent inhibitor.
价 格：￥电议型 号：T8684产 地：中国大陆
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TQ0127NavtemadlinNavtemadlin,MDM-2/p53,inhibit,Ubiquitin ligase,Ubiquitin activating enzyme,E3 ligating en
AMG 232 is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
价 格：￥电议型 号：TQ0127产 地：中国大陆
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T7189AMG9810Transient receptor potential channels,inhibit,Inhibitor,AMG-9810,AMG9810,AMG 9810,TRP Channel
AMG 9810 is a competitive antagonist of capsaicin activation of the vanilloid receptor 1 (TRPV1) (IC50s = 24.5 and 85.6 nM for human and rat TRPV1, respectively).
价 格：￥电议型 号：T7189产 地：中国大陆
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T6380AMG 900AMG 900,Inhibitor,Aurora Kinase,inhibit
AMG 900 is a potent and highly selective pan-Aurora kinases inhibitor for Aurora A/B/C with IC50 of 5 nM/4 nM /1 nM. It is >10-fold selective for Aurora kinases than p38α, Tyk2, JNK2, Met and Tie2. Phase 1.
价 格：￥电议型 号：T6380产 地：中国大陆
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TP1236Etelcalcetide hydrochlorideEtelcalcetide hydrochloride,KAI-4169,AMG416,KAI4169,CaSR,KAI 4169,AMG 416
Etelcalcetide hydrochloride is a synthetic peptide as an allosteric modulator of the calcium (Ca)-sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis.
价 格：￥电议型 号：TP1236产 地：中国大陆
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T12655(Rac)-AMG8379
(Rac)-AMG8379 is a racemate of AMG8379 which is an orally active and selective sulfonamide NaV1.7 antagonist.
价 格：￥电议型 号：T12655产 地：中国大陆
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TQ0055AMG-3969Hexokinase IV,AMG 3969,Hexokinase D,Glucokinase,Inhibitor,AMG3969,AMG-3969,inhibit
AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).
价 格：￥电议型 号：TQ0055产 地：中国大陆
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T6378AMG-458AMG458,inhibit,Inhibitor,c-Met/HGFR,AMG-458
AMG 458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.
价 格：￥电议型 号：T6378产 地：中国大陆
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T6757AMG319AMG-319,AMG 319,Inhibitor,inhibit,PI3K,AMG319,Phosphoinositide 3-kinase
AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.
价 格：￥电议型 号：T6757产 地：中国大陆
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T6379AMG 517AMG 517,Inhibitor,inhibit,Transient receptor potential channels,TRP Channel
AMG 517 is an effective and specific TRPV1 antagonist, antagonizes proton (IC50: 0.76 nM), capsaicin (IC50: 0.62 nM), and heat activation (IC50: 1.3 nM) of TRPV1.
价 格：￥电议型 号：T6379产 地：中国大陆
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T17232VidupiprantProstaglandin Receptor,AMG-853,Inhibitor,orally,acid,cAMP,phenylacetic,asthma,PGD2,AMG 00
Vidupiprant is an effective dual antagonist of CRTH2 and prostanoid D receptor with IC50s of 8 nM and 35 nM in human plasma. Vidupiprant can be used in studies about the treatment of asthma.
价 格：￥电议型 号：T17232产 地：中国大陆
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T2288LMotesanib DiphosphateMotesanib Diphosphate,c-Kit,inhibit,AMG 706 Diphosphate,Vascular endothelial gr
Motesanib Diphosphate is the orally bioavailable diphosphate salt of a multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity.
价 格：￥电议型 号：T2288L产 地：中国大陆
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T9920EvolocumabAMG-145,Ser/Thr Protease,Repatha,AMG 145,inhibit,atherosclerotic cardiovascular disease,Se
Evolocumab is a human IgG2 monoclonal antibody that binds to human PCSK9 Proprotein Convertase Subtilisin Kexin Type 9).
价 格：￥电议型 号：T9920产 地：中国大陆
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TQ0020AMG 837 calcium hydrateAMG 837 calcium,FFAR,AMG 837 calcium hydrate,insulin,FFA1,Inhibitor,Free Fatt
AMG 837 calcium hydrate is a potent GPR40 agonist with an EC50 of 13 nM. AMG 837 calcium hydrate also shows highly selective over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM).
价 格：￥电议型 号：TQ0020产 地：中国大陆
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T14217AMG 579
AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).
价 格：￥电议型 号：T14217产 地：中国大陆
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T8780AMG131AMG131,proliferator,inhibit,Inhibitor,activated,Peroxisome proliferator-activated receptors,IN
INT-131, is a novel, non-thiazolidinedione (TZD), selective peroxisome proliferator-activated receptor (PPAR)gamma modulator, which can be used for the treatment of type 2 diabetes mellitus (non-insulin dependent diabetes)
价 格：￥电议型 号：T8780产 地：中国大陆
