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T74606A2A/A3u00A0AR antagonist-1;化合物 A2A/A3u00A0AR antagonist-1A2A/A3u00A0AR antagonist-1
Compound 23, designated as A2A/A3 AR antagonist-1, is a dual fluorescent ligand targeting A2A and A3 adenosine receptors (AR), exhibiting dissociation constants (Ki) of 90 nM for hA2A AR and 31.8 nM for hA3 AR, respectively [1].
价 格:¥电议型 号:T74606产 地:中国大陆
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T74592Sitagliptin fenilalanil hydrochloride;化合物 Sitagliptin fenilalanil hydrochlorideSitagliptin fenilalan
Sitagliptin phenylalanine hydrochloride, a dipeptidyl peptidase-4 (DPP-4) inhibitor [1], is a chemical compound utilized in medical applications.
价 格:¥电议型 号:T74592产 地:中国大陆
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T74556dTAG-47;化合物 dTAG-47dTAG-47
dTAG-47, a heterobifunctional molecule, specifically targets the mutant FKBP12 (FKBP12 F36V), which functions as a degradation tag (dTAG) when fused to a protein of interest. This compound is utilized in the study of basal-like breast cancers (BBC) [1].
价 格:¥电议型 号:T74556产 地:中国大陆
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T74538Galectin-3 antagonist 2;化合物 Galectin-3 antagonist 2Galectin-3 antagonist 2
Galectin-3, a β-galactoside-specific carbohydrate recognition protein (lectin), facilitates the migration of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) cells and demonstrates resistance to pharmaceutical interventions.
价 格:¥电议型 号:T74538产 地:中国大陆
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T74412dTAGV-1-NEG TFA;化合物 dTAGV-1-NEG TFAdTAGV-1-NEG TFA
dTAGV-1-NEG TFA, a diastereomer, serves as the heterobifunctional negative control for dTAGV-1. It acts specifically as an FKBP12 F36V-selective degrader [1].
价 格:¥电议型 号:T74412产 地:中国大陆
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T74350Neuropeptide Y Y1u00A0receptor antagonist 1;化合物 Neuropeptide Y Y1u00A0receptor antagonist 1Neuropept
Neuropeptide Y Y1 receptor antagonist 1 (compound 39), a fluorescent probe, serves as a powerful antagonist against the neuropeptide Y Y1 receptor (Y1R), exhibiting a K? value of 0.19 nM [1]. It should be stored in conditions shielded from light.
价 格:¥电议型 号:T74350产 地:中国大陆
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T74266Protease-Activated Receptor-1 antagonistu00A02;化合物 Protease-Activated Receptor-1 antagonistu00A02Pro
Protease-Activated Receptor-1 Antagonist 2 is an orally active antagonist of protease-activated receptor-1 (PAR-1), demonstrating significant potency with an IC 50 of 7 nM. It exhibits favorable pharmacokinetic characteristics, making it valuable in cardiovascular disease (CVD) research, including studies on atherosclerosis and restenosis [1].
价 格:¥电议型 号:T74266产 地:中国大陆
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T73875Fotagliptin benzoate;化合物 Fotagliptin benzoateFotagliptin benzoate
Fotagliptin benzoate, a Dipeptidyl Peptidase IV (DPP-4) inhibitor with an inhibitory concentration (IC50) of 2.27 nM, demonstrates significant safety in both rat and dog models. It is utilized in Type 2 diabetes mellitus research [1].
价 格:¥电议型 号:T73875产 地:中国大陆
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T73782Prostaglandin J2;化合物 Prostaglandin J2Prostaglandin J2
Prostaglandin J2 (PGJ2), a derivative of Prostaglandin D2 (PGD2), serves as a potent agonist for PGD2 receptors (DP), exhibiting affinity constants (K i) of 0.9 nM and 6.6 nM for hDP and hCRTH2 receptors, respectively. It activates cyclic AMP production with an EC50 of 1.2 nM, induces oxidative stress, neuronal apoptosis, and promotes the accumulation of ubiquitinated (Ub) proteins. Notably, PGJ2´s neurotoxic properties are implicated in the progression of neurodegenerative diseases such a
价 格:¥电议型 号:T73782产 地:中国大陆
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T7347CU-CPT-8m;化合物CU-CPT-8mTLR8-specific antagonist;TLR8-specific antagonist
CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
价 格:¥电议型 号:T7347产 地:中国大陆
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T7302CU-CPT9b;化合物CU-CPT9bCU-CPT-9b|||TLR8-specific antagonist 1;CU-CPT-9b|||TLR8-specific antagonist 1
CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.
价 格:¥电议型 号:T7302产 地:中国大陆
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T72626A2AR-antagonist-1;化合物 A2AR-antagonist-1A2AR-antagonist-1
A2AR-antagonist-1 (compound 38), an orally active adenosine A2A receptor antagonist with an IC50 value of 29 nM, demonstrates anti-tumor properties and stability in mouse liver microsomes (t1/2 = 86.1 min). Additionally, it activates T cells by inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and promoting expression of effector molecules (GZMB, IFNG, and IL-2) [1].
价 格:¥电议型 号:T72626产 地:中国大陆
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T72625LTB4 antagonist 1;化合物 LTB4 antagonist 1LTB4 antagonist 1
LTB4 Antagonist 1, a carboxamide-acid derivative, potently inhibits Leukotriene B4 (LTB4) activity with an IC50 value of 288 nM and exhibits notable anti-inflammatory properties [1].
价 格:¥电议型 号:T72625产 地:中国大陆
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T72621GCGR antagonist 2;化合物 GCGR antagonist 2GCGR antagonist 2
GCGR Antagonist 2, a Furan-2-carbohydrazide, serves as an orally active antagonist of the glucagon receptor. It exhibits affinity for the human glucagon receptor (hGluR) with a dissociation constant (Kd) of 2.3 nM and demonstrates inhibitory activity against the rat receptor with a half-maximal inhibitory concentration (IC50) of 0.43 nM. Additionally, this compound effectively prevents glucagon-stimulated glycogenolysis.
价 格:¥电议型 号:T72621产 地:中国大陆
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T72606AT1R antagonist 1;化合物 AT1R antagonist 1AT1R antagonist 1
AT1R Antagonist 1 (compound 10) serves as a potent, selective ligand for AT1R with considerable affinity, demonstrated by a K i value of 8.5 nM [1].
价 格:¥电议型 号:T72606产 地:中国大陆
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T72588A3AR antagonist 2;化合物 A3AR antagonist 2A3AR antagonist 2
A3AR antagonist 2 is a potent antagonist of the human A3 adenosine receptor, exhibiting a Ki value of 4.54 nM.
价 格:¥电议型 号:T72588产 地:中国大陆
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T72536GPR84 antagonist 2;化合物 GPR84 antagonist 2GPR84 antagonist 2
GPR84 Antagonist 2, a potent and selective GPR84 antagonist (IC 50 = 8.95 nM), demonstrates oral activity and significantly enhances potency in calcium mobilization assays. It effectively inhibits neutrophil and macrophage chemotaxis following GPR84 activation, highlighting its research potential for ulcerative colitis.
价 格:¥电议型 号:T72536产 地:中国大陆
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T72492GnRH-R antagonist 1;化合物 GnRH-R antagonist 1GnRH-R antagonist 1
GnRH-R antagonist 1 (Compound 21a), is an orally active, membrane-permeable agent with a high binding affinity (IC50=0.57 nM) and potent in vitro antagonistic efficacy (IC50=2.18 nM). It is utilized in research focused on advanced prostate cancer and the prevention of premature LH surges [1].
价 格:¥电议型 号:T72492产 地:中国大陆
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T72473NOD1/2 antagonist-1;化合物 NOD1/2 antagonist-1NOD1/2 antagonist-1
NOD1/2 Antagonist-1 is a potent dual inhibitor of nucleotide-binding oligomerization domain-like receptors 1 and 2 (NOD1/2), displaying inhibitory concentrations (IC50) of 1.13 μM for NOD1 and 0.77 μM for NOD2. It exhibits an acceptable half-life (T1/2) of 67.6 minutes. Additionally, NOD1/2 Antagonist-1 enhances the antitumor efficiency of Paclitaxel (PTX).
价 格:¥电议型 号:T72473产 地:中国大陆
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T72410Sortilin antagonist 1;化合物 Sortilin antagonist 1Sortilin antagonist 1
Sortilin Antagonist 1, a potent sortilin antagonist, exhibits an inhibition constant (IC50) of 20 nM against Neurotensin (NTS) binding to sortilin. Neurotensin acts as a sortilin ligand. This compound is utilized in neurological disease research.
价 格:¥电议型 号:T72410产 地:中国大陆