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  • T74522ALK-IN-21；化合物 ALK-IN-21ALK-IN-21

    ALK-IN-21 (Compound B10), a proficient ALK inhibitor targeting the ALKG1202R mutation, demonstrates significant inhibitory activity, with IC50 values of 4.59 nM against ALK WT, 2.07 nM against ALK L1196M, and 5.95 nM against ALK G1202R. Moreover, ALK-IN-21 effectively suppresses proliferation in ALK-positive Karpas299 and H2228 cells, achieving IC50 values of 0.07 μM. It is applicable for anaplastic large cell lymphoma research [1].

    价 格：￥电议型 号：T74522产 地：中国大陆

  • T74491Antitumor agent-61；化合物 Antitumor agent-61Antitumor agent-61

    Antitumor agent-61 (Compound 9b), an Irinotecan (Ir) derivative, demonstrates potent anticancer activity, as evidenced by its IC50 values ranging from 0.92 to 3.23 μM against six human cancer cell lines: SK-OV-3, SK-OV-3/CDDP, U2OS, MCF-7, A549, and MG-63. It specifically induces apoptosis in SK-OV-3 cells via mitochondrial pathways [1].

    价 格：￥电议型 号：T74491产 地：中国大陆

  • T74392Antimicrobial photosensitizer-1；化合物 Antimicrobial photosensitizer-1Antimicrobial photosensitizer-1

    Antimicrobial Photosensitizer-1 demonstrates significant potential as an effective agent for treating infections caused by pathogenic microorganisms, with notable antimicrobial efficacy observed in S. aureus-infected mouse wound models [1].

    价 格：￥电议型 号：T74392产 地：中国大陆

  • T74341Antibacterial agent 71；化合物 Antibacterial agent 71Antibacterial agent 71

    The compound demonstrates enhanced potency against wild-type (WT) strains of Escherichia coli, Acinetobacter baumannii, and Burkholderia cenocepacia, showing significant improvements of up to (>128-fold) due to increased outer-membrane permeability in hyperpermeable E. coli strains and S. Tm.

    价 格：￥电议型 号：T74341产 地：中国大陆

  • T74327Antitumor agent-41；化合物 Antitumor agent-41Antitumor agent-41

    Antitumor Agent-41 (Compound N-12) exhibits potent antitumor properties, demonstrating significant antimigration and anti-invasion activities. It induces tumor inhibition through tumor necrosis and inflammatory response [1].

    价 格：￥电议型 号：T74327产 地：中国大陆

  • T74220Antifungal agent 21；化合物 Antifungal agent 21Antifungal agent 21

    Antifungal Agent 21 presents as a promising candidate within the development of novel agrochemical antifungal agents.

    价 格：￥电议型 号：T74220产 地：中国大陆

  • T74217Angiogenesis agent 1；化合物 Angiogenesis agent 1Angiogenesis agent 1

    Angiogenesis Agent 1 (Compound C-31), a glycoside analogue derived from salidroside, acts as an activator of the HIF-1α pathway and shows potential in diabetic hind limb ischemia research [1].

    价 格：￥电议型 号：T74217产 地：中国大陆

  • T74158Aβ Fibrillization modulator 1；化合物 Aβ Fibrillization modulator 1Aβ Fibrillization modulator 1

    Aβ Fibrillization Modulator 1 stabilizes amyloid-beta (Aβ) monomers, preventing their aggregation into fibrils.

    价 格：￥电议型 号：T74158产 地：中国大陆

  • T74025AUTAC1；化合物 AUTAC1AUTAC1

    AUTAC1 is a MetAP2-targeted autophagy-mediated degrader (AUTAC) with potential anticancer activity that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.

    价 格：￥电议型 号：T74025产 地：中国大陆

  • T73998ADAM8-IN-1；化合物 ADAM8-IN-1ADAM8-IN-1

    ADAM8-IN-1 is a potent ADAM8 inhibitor with an IC 50 value of 73 nM.

    价 格：￥电议型 号：T73998产 地：中国大陆

  • T73997Anti gram-positive/negative bacteria agent 1；化合物 Anti gram-positive/negative bacteria agent 1Anti gr

    Anti gram-positive/negative bacteria agent 1 is an antibiotic linked with a synthetic MECAM-based siderophore, serving as a conjugate aimed at combating gram-positive and gram-negative bacteria.

    价 格：￥电议型 号：T73997产 地：中国大陆

  • T73693Peginterferon beta-1a；化合物 Peginterferon beta-1aPeginterferon beta-1a

    Peginterferon beta-1a (Peginterferon β-1a), the inaugural pegylated interferon beta-1a derivative, promotes apoptosis in cancer cells and exhibits anti-tumor properties in nude mice models. It is utilized in the study of cancer and relapsing multiple sclerosis (RMS) [1].

    价 格：￥电议型 号：T73693产 地：中国大陆

  • T73678Antibiotic DC 81；化合物 Antibiotic DC 81Antibiotic DC 81

    Antibiotic DC 81, a pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumor antibiotic produced by Streptomyces species, acts as a potent inhibitor of nucleic acid synthesis. It specifically recognizes and binds to certain DNA sequences, forming a labile covalent adduct [1] [2].

    价 格：￥电议型 号：T73678产 地：中国大陆

  • T73436AK-IN-1；化合物 AK-IN-1AK-IN-1

    AK-IN-1, a competitive inhibitor for adenosine (Ado) but not for ATP, demonstrates significant inhibition of AK activity, achieving 86%, 87%, and 89% at concentrations of 2, 4, and 10 ?M, respectively. This compound shows promise for research across various disease areas, such as ischemia, inflammation, and seizures.

    价 格：￥电议型 号：T73436产 地：中国大陆

  • T73352A-943931；化合物 A-943931A-943931

    A-943931, a selective and potent antagonist of the histamine H4 receptor (H4R), demonstrates affinity with pKi values of 4.6 and 3.8 nM for human and rat H4Rs, respectively. This compound exhibits anti-inflammatory and antinociceptive properties.

    价 格：￥电议型 号：T73352产 地：中国大陆

  • T73255Akt1-IN-1；化合物 Akt1-IN-1Akt1-IN-1

    Akt1-IN-1 is a potent and selective inhibitor of Akt1, demonstrating an IC50 of 18.79 nM in MIA PaCa-2 cells, indicating its high efficacy in inhibiting this specific kinase. Notably, it shows no significant teratogenicity, hepatotoxicity, or cardiotoxicity (No Observed Adverse Effect Level > 100 ?M), making it a viable candidate for anticancer research.

    价 格：￥电议型 号：T73255产 地：中国大陆

  • T73224AMPK-IN-1；化合物 AMPK-IN-1AMPK-IN-1

    AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM. It induces phosphorylation of eEF2 independent of the mTORC1 pathway.

    价 格：￥电议型 号：T73224产 地：中国大陆

  • T73148ACT-777991；化合物 ACT-777991ACT-777991

    ACT-777991 is an orally active, selective CXCR3 antagonist with demonstrated stability in microsomes and hepatocytes across various animal models. This compound effectively inhibits the migration of activated T cells toward CXCL11.

    价 格：￥电议型 号：T73148产 地：中国大陆

  • T72910APOBEC3G-IN-1；APOBEC3G 抑制剂1APOBEC3G-IN-1

    APOBEC3G-IN-1 (MN136.0185) is a targeted APOBEC3G inhibitor with anti-HIV activity for the study of infectious diseases and cancer.

    价 格：￥电议型 号：T72910产 地：中国大陆

  • T72892AChE/MAO-IN-1；化合物 AChE/MAO-IN-1AChE/MAO-IN-1

    AChE/MAO-IN-1 is a potent inhibitor of human acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), and monoamine oxidase B (MAO-B), demonstrating inhibitory concentrations (IC50) of 0.0248 μM, 0.0409 μM, and 0.1108 μM against AChE, MAO-A, and MAO-B, respectively.

    价 格：￥电议型 号：T72892产 地：中国大陆

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