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  • T72885Akt1&PKA-IN-1；化合物 Akt1&PKA-IN-1Akt1&PKA-IN-1

    Akt1&PKA-IN-1 is a potent dual inhibitor targeting Akt and PKA, exhibiting IC50 values of 0.11 μM for Akt, 0.03 μM for PKAα, and 9.8 μM for CDK2. Notably, it demonstrates selectivity for cyclin-dependent kinase 2 (CDK2).

    价 格：￥电议型 号：T72885产 地：中国大陆

  • T72763AChE/BuChE-IN-1；化合物 AChE/BuChE-IN-1AChE/BuChE-IN-1

    AChE/BuChE-IN-1, a selective butyrylcholinesterase (BuChE) inhibitor derived from chrysin, exhibits a potent efficacy with an IC50 of 0.48 μM against BuChE and a lesser inhibitory effect on acetylcholinesterase (AChE) with an IC50 of 7.16 μM. It demonstrates significant hydroxyl radical (·OH) scavenging activity, achieving an IC50 of 0.1674 μM, and effectively inhibits reactive oxygen species (ROS) and Aβ 1-42 aggregation, including self-aggregation, copper (Cu 2+)-induced, and AChE-induced aggr

    价 格：￥电议型 号：T72763产 地：中国大陆

  • T72717Anti-IAV agent 1；化合物 Anti-IAV agent 1Anti-IAV agent 1

    Anti-IAV Agent 1-1a is an orally administered compound effective against the Influenza A virus (IAV), demonstrating inhibitory concentration 50 (IC50) values of 0.03 μM and 0.06 μM for the H1N1 strain and the Oseltamivir-resistant H1N1 strain of IAV, respectively.

    价 格：￥电议型 号：T72717产 地：中国大陆

  • T72661A1AT modulator 2；化合物 A1AT modulator 2A1AT modulator 2

    A1AT Modulator 2, an α-1 antitrypsin (A1AT) modulator, exhibits an IC50 value greater than 1.0 μM and an EC50 value less than 0.4 μM. It is utilized in the study of infection and inflammation.

    价 格：￥电议型 号：T72661产 地：中国大陆

  • T72626A2AR-antagonist-1；化合物 A2AR-antagonist-1A2AR-antagonist-1

    A2AR-antagonist-1 (compound 38), an orally active adenosine A2A receptor antagonist with an IC50 value of 29 nM, demonstrates anti-tumor properties and stability in mouse liver microsomes (t1/2 = 86.1 min). Additionally, it activates T cells by inhibiting immunosuppressive molecules (LAG-3 and TIM-3) and promoting expression of effector molecules (GZMB, IFNG, and IL-2) [1].

    价 格：￥电议型 号：T72626产 地：中国大陆

  • T72606AT1R antagonist 1；化合物 AT1R antagonist 1AT1R antagonist 1

    AT1R Antagonist 1 (compound 10) serves as a potent, selective ligand for AT1R with considerable affinity, demonstrated by a K i value of 8.5 nM [1].

    价 格：￥电议型 号：T72606产 地：中国大陆

  • T72574Axl/Mer/CSF1R-IN-1；化合物 Axl/Mer/CSF1R-IN-1Axl/Mer/CSF1R-IN-1

    Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds) of less than 0.1 μM.

    价 格：￥电议型 号：T72574产 地：中国大陆

  • T72560Antitumor agent-81；化合物 Antitumor agent-81Antitumor agent-81

    Antitumor agent-81, a P62-RNF168 agonist with low cytotoxicity, enhances the P62-RNF168 interaction, leading to decreased RNF168-mediated H2A ubiquitination and impaired homologous recombination-mediated DNA repair. Additionally, it exhibits dose-dependent inhibition of xenograft tumor growth in mice.

    价 格：￥电议型 号：T72560产 地：中国大陆

  • T72553ARTD10/PARP10-IN-1；ARTD10/PARP10抑制剂1ARTD10/PARP10-IN-1

    ARTD10/PARP10-IN-1 is a potent PARP inhibitor of the mono-ADP ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly ADP-ribose polymerase-1 (ARTD1/PARP1), with potential anticancer and antitumour activity for the study of prostate and breast cancers.

    价 格：￥电议型 号：T72553产 地：中国大陆

  • T72522Aurora kinase-IN-1；化合物 Aurora kinase-IN-1Aurora kinase-IN-1

    Aurora kinase-IN-1, a potent aurora kinase inhibitor, modulates cell cycle progression and induces apoptosis by upregulating G1 cell cycle inhibitory proteins (including p21 and p27), elevating G1 progressive cyclin D1, and downregulating G1-to-S progressive cyclins, thereby arresting the cell cycle at the G1/S boundary. It stands as a promising lead compound for the development of chemotherapeutic agents.

    价 格：￥电议型 号：T72522产 地：中国大陆

  • T72503Antitubulin agent 1；化合物 Antitubulin agent 1Antitubulin agent 1

    Antitubulin Agents-1, an antitubulin agent, disrupts microtubules (Microtubule/Tubulin) and enhances α-tubulin acetylation, exhibiting anticancer effects.

    价 格：￥电议型 号：T72503产 地：中国大陆

  • T72417AChE/Nrf2 modulator 1；化合物 AChE/Nrf2 modulator 1AChE/Nrf2 modulator 1

    AChE/Nrf2 modulator 1, an orally active compound, serves as a modulator of acetylcholinesterase (AChE) and nuclear factor erythroid 2-related factor 2 (Nrf2). It exhibits Nrf2 inductive activity alongside inhibitory effects on eeAChE and hAChE, demonstrating IC 50 values of 0.07 μM and 0.38 μM, respectively. This compound is applicable in Alzheimer´s disease research.

    价 格：￥电议型 号：T72417产 地：中国大陆

  • T72349Antibacterial agent 91；化合物 Antibacterial agent 91Antibacterial agent 91

    Antibacterial agent 91, a triple-site aminoacyl-tRNA synthetase (aaRS) inhibitor, demonstrates efficacy with an IC50 of 2.10 μM against Salmonella enterica threonyl-tRNA synthetase (Se ThrRS), thereby exhibiting antibacterial activities.

    价 格：￥电议型 号：T72349产 地：中国大陆

  • T72323Antiarrhythmic agent-1；化合物 Antiarrhythmic agent-1Antiarrhythmic agent-1

    Antiarrhythmic agent-1 (example I), functioning as an antiarrhythmic agent and an IKr potassium channel blocker (IC 50 <1 μM), effectively inhibits cardiac arrhythmias.

    价 格：￥电议型 号：T72323产 地：中国大陆

  • T72309Antibacterial agent 131；抗菌剂131Antibacterial agent 131

    Antibacterial agent 131 is a compound with antibacterial properties.

    价 格：￥电议型 号：T72309产 地：中国大陆

  • T72229Antitrypanosomal agent 11；化合物 Antitrypanosomal agent 11Antitrypanosomal agent 11

    Antitrypanosomal Agent 11 is a chemical compound effective against Trypanosoma cruzi, exhibiting an inhibition concentration (IC 50) of 0.23 μM.

    价 格：￥电议型 号：T72229产 地：中国大陆

  • T72200Antiproliferative agent-11；化合物 Antiproliferative agent-11Antiproliferative agent-11

    Antiproliferative Agent-11, a selective Ruthenium(II)-Tris-pyrazolylmethane complex, exhibits antiproliferative effects on MCF-7, HeLa, 518A2, HCT116, and RD cancer cell lines with IC50 values of 6, 10, 6.8, 6.7, and 6 μM, respectively. This compound is utilized in cancer research.

    价 格：￥电议型 号：T72200产 地：中国大陆

  • T72180Acetyl-CoA Carboxylase-IN-1；化合物 Acetyl-CoA Carboxylase-IN-1Acetyl-CoA Carboxylase-IN-1

    Acetyl-CoA Carboxylase-IN-1 is a potent inhibitor of acetyl-CoA carboxylase (ACC), exhibiting an inhibition concentration (IC50) of less than 5 nM. This compound also displays antibacterial activity.

    价 格：￥电议型 号：T72180产 地：中国大陆

  • T72020AM6701；化合物 AM6701AM6701

    AM6701 is a novel highly potent inhibitor of human alpha/beta hydrolase domain 6 (habhd6)

    价 格：￥电议型 号：T72020产 地：中国大陆

  • T71955C3001a；化合物 C3001aC3001a

    C3001a is a selective activator for TREK, against other two-pore domain K+(K2P) channels. C3001a binds to the cryptic binding site formed by P1 and TM4 in TREK-1. C3001a targets TREK channels in the peripheral nervous system to reduce the excitability of nociceptive neurons. In neuropathic pain, C3001a alleviated spontaneous pain and cold hyperalgesia. In a mouse model of acute pancreatitis, C3001a alleviated mechanical allodynia and inflammation. C3001a represents a lead compound which could a

    价 格：￥电议型 号：T71955产 地：中国大陆

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