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T62178TLR7/8 antagonist 1;化合物 TLR7/8 antagonist 1TLR7/8 antagonist 1
TLR7/8 Antagonist 1 (Compound 16c), an imidazoquinoline derivative, is a potent TLR7/8 agonist with IC50 values of 3.91 and 2.19 μM for TLR7 and TLR8, respectively. rel-O-2050 (TLR-2050) is a key target for drug development in infectious diseases, cancer and autoimmune diseases.
价 格:¥电议型 号:T62178产 地:中国大陆
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T62177TLR7/8 agonist 6;化合物 TLR7/8 agonist 6TLR7/8 agonist 6
TLR7/8 agonist 6 (Compound 4), an imidazoquinoline derivative, is a potent TLR7/8 agonist with IC50 values of 0.18 and 5.34 μM for TLR7 and TLR8, respectively. TLR7/8 Antagonist
价 格:¥电议型 号:T62177产 地:中国大陆
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T61826NLRP3-IN-4;化合物 NLRP3-IN-4NLRP3-IN-4
NLRP3-IN-4 is a highly efficient and orally bioavailable inhibitor of NLRP3 inflammasome, which exhibits strong anti-inflammatory properties specifically targeted towards colitis.
价 格:¥电议型 号:T61826产 地:中国大陆
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T61601TLR7/8 antagonist 2;化合物 TLR7/8 antagonist 2TLR7/8 antagonist 2
TLR7/8 antagonist 2 (Compound 15) is a highly potent and orally active agonist of TLR7/8, exhibiting IC50 values of 4.9 and 0.6 nM for TLR7 and TLR8, respectively. Its strong affinity for these receptors makes it a promising candidate for the treatment and investigation of autoimmune diseases, including lupus erythematosus, which is associated with inappropriate activation of TLR7 and TLR8. Consequently, TLR7/8 antagonist 2 represents a valuable tool for research in the field of autoimmune disea
价 格:¥电议型 号:T61601产 地:中国大陆
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T61392NLRP3-IN-10;化合物NLRP3-IN-10ZVN26391;ZVN26391
NLRP3-IN-10 (ZVN26391) is a potent NLRP3 inhibitor. NLRP3-IN-10 inhibits IL-1β release with an IC50 value of 251.1 nM. NLRP3-IN-10 attenuates ASC speck formation, leading to suppress activation of NLRP3 inflammasome.
价 格:¥电议型 号:T61392产 地:中国大陆
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T61132NLRP3-IN-11;NLRP3抑制剂11NLRP3-IN-11
NLRP3-IN-11 is an NLRP3 protein inhibitor with potential anti-inflammatory activity.NLRP3-IN-11 can be used in the study of atherosclerosis and parkinsonism.
价 格:¥电议型 号:T61132产 地:中国大陆
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T60894TLR7/8 agonist 4;化合物 TLR7/8 agonist 4TLR7/8 agonist 4
TLR7/8 agonist 4 (compound 41) is a potent agonist of TLR7/8 with anti-cancer activity [1].
价 格:¥电议型 号:T60894产 地:中国大陆
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T608595-Pentadecylresorcinol;化合物 5-Pentadecylresorcinol5-Pentadecylresorcinol
5-Pentadecylresorcinol (Adipostatin A) has good larvicidal activity against Aedes aegypti that is an inhibitor of glycerol-3-phosphate dehydrogenase (GPDH) with an IC 50 of 4.1 μM [1] [2].
价 格:¥电议型 号:T60859产 地:中国大陆
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T60756NLRP3 antagonist 1;化合物 NLRP3 antagonist 1NLRP3 antagonist 1
NLRP3 antagonist 1 shows potential for the cancer research that is a potent NLRP3 antagonist. NLRP3 is involved in the body´s intrinsic immunity against stress injury and pathogenic infections that is mainly expressed in macrophages and neutrophils [1].
价 格:¥电议型 号:T60756产 地:中国大陆
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T60563NLRP3/AIM2-IN-1;化合物 NLRP3/AIM2-IN-1NLRP3/AIM2-IN-1
NLRP3/AIM2-IN-1 is an inhibitor of thermal sepsis (IC50 = 3.136 ± 0.7667 μM).
价 格:¥电议型 号:T60563产 地:中国大陆
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T60442NLRP3/AIM2-IN-3;化合物NLRP3/AIM2-IN-3NLRP3/AIM2-IN-3
NLRP3/AIM2-IN-3 is a unique molecule that inhibits NLRP3 and AIM2 inflammasome activation in a species-specific manner. It has an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 is a potent inhibitor of NLRP3 and AIM2 inflammasome-dependent cell lysis with an IC50 value for cell lysis of 0.077 ± 0.008 μ M. NLRP3/AIM2-IN-3 inhibits LPS/nigericin NLRP3/AIM2-IN-3 inhibits LPS/nigericin-stimulated cell lysis in THP-1 macrophages with an IC50 value of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3
价 格:¥电议型 号:T60442产 地:中国大陆
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T60404NLRP3/AIM2-IN-2;化合物NLRP3/AIM2-IN-2NLRP3/AIM2-IN-2
NLRP3/AIM2-IN-2 is a novel potent inhibitor with different species-specific effects on NLRP3 and AIM2 inflammasome dependent pyroptosis with IC50 of 0.2392 ± 0.0233 μ M.
价 格:¥电议型 号:T60404产 地:中国大陆
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T60249RhlR antagonist 1;化合物 RhlR antagonist 1RhlR antagonist 1
RhlR antagonist 1 is a highly effective antagonist of the RhlR protein, showing an IC50 value of 26 μM. It exhibits selective antagonistic activity against RhlR, with minimal effect on LasR and PqsR. RhlR antagonist 1 strongly inhibits biofilm formation in both static and dynamic environments and reduces the production of virulence factors, such as rhamnolipid and pyocyanin, in P. aeruginosa. These characteristics make RhlR antagonist 1 a valuable tool for the development of molecules that modul
价 格:¥电议型 号:T60249产 地:中国大陆
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T5843TarenflurbilR-氟比洛芬MPC7869|||(R)-Flurbiprofen|||R-flurbiprofen|||氟比洛芬|||R-氟比洛芬
Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer´s disease.
价 格:¥电议型 号:T5843产 地:中国大陆
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T5668Triacetylresveratrol三乙酰基白藜芦醇乙酰化白藜芦醇|||三乙酰基白藜芦醇|||Acetyl-trans-resveratrol
Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.
价 格:¥电议型 号:T5668产 地:中国大陆
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T5561TLR7/8 agonist 1 dihydrochloride;二盐酸TLR7/8 agonist 1TLR7/8 agonist-5d;TLR7/8 agonist-5d|||二盐酸TLR7/8
TLR7/8 agonist 1 dihydrochloride (TLR7/8 agonist-5d) is a TLR7/8 agonist which shows prominent immunostimulatory activities.
价 格:¥电议型 号:T5561产 地:中国大陆
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T5385Radiprodil;化合物RadiprodilRGH-896;RGH-896
Radiprodil (RGH-896) (RGH-896) is an orally active and selective NMDA NR2B receptors antagonist. It was a potential treatment of neuropathic pain associated with diabetic peripheral neuropathy (DPNP).
价 格:¥电议型 号:T5385产 地:中国大陆
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T5336LZacopride;化合物 T5336LRacemic zacopride;Racemic zacopride
Zacopride is a selective agonist of inward rectifier potassium current (I K1) channel, inhibiting ventricular arrhythmias without affecting atrial arrhythmias.
价 格:¥电议型 号:T5336L产 地:中国大陆
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T5195LAlrestatin Sodium;化合物 T5195LAY 22284A|||AY-22284A|||Alrestatine sodium|||AY22284A;AY 22284A|||AY-222
Alrestatin is a specific inhibitor of the aldose reductase enzyme.
价 格:¥电议型 号:T5195L产 地:中国大陆
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T5195Alrestatin;阿瑞司他丁AY-22284|||阿瑞司他丁|||AY22284|||AY22284|||Aldose Reductase|||AY-22284|||inhibit|||Inhib
Alrestatin (AY-22284) is a specific inhibitor of aldose reductase and attenuates glucose-induced angiotensin II production in rat vascular smooth muscle in vitro.
价 格:¥电议型 号:T5195产 地:中国大陆