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T74683IONIS-FB-LRx；化合物 IONIS-FB-LRxIONIS-FB-LRx
IONIS-FB-LRx, a targeted antisense oligonucleotide (ASO) specifically designed to inhibit complement factor B (CFB), effectively lowers circulating CFB levels. This compound has potential applications in geographic atrophy (GA) research [1] [2].
价 格：￥电议型 号：T74683产 地：中国大陆
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T74468MC-Val-Cit-PAB-Amide-TLR7 agonist 4；化合物 MC-Val-Cit-PAB-Amide-TLR7 agonist 4MC-Val-Cit-PAB-Amide-TLR7
MC-Val-Cit-PAB-Amide-TLR7 agonist 4 (example 15) is a conjugate that acts as an immune agonist targeting both HER2-TLR7 and HER2-TLR8 pathways [1].
价 格：￥电议型 号：T74468产 地：中国大陆
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T74389Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH；化合物 Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-am
Tri(TLR4-IN-C34-C2-amide-C3-amide-PEG1)-amide-C3-COOH, a chemical compound, serves as a linker incorporating TLR4 inhibitor TLR4-IN-C34. This compound effectively inhibits TLR4 in both enterocytes and macrophages, significantly reducing systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis [1].
价 格：￥电议型 号：T74389产 地：中国大陆
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T74388Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH；化合物 Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOHTri
Tri(TLR4-IN-C34-PEG2-amide-PEG1)-amide-C3-COOH is a chemical linker incorporating the TLR4 inhibitor, TLR4-IN-C34, which suppresses TLR4 activity in enterocytes and macrophages, consequently diminishing systemic inflammation observed in mouse models of endotoxemia and necrotizing enterocolitis [1].
价 格：￥电议型 号：T74388产 地：中国大陆
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T74387Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH；化合物 Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOHTri(TLR
Tri(TLR4-IN-C34-C2-amide-PEG1)-amide-C3-COOH is a chemical linker featuring the TLR4 inhibitor TLR4-IN-C34, known for inhibition of TLR4 in enterocytes and macrophages, thereby diminishing systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis [1].
价 格：￥电议型 号：T74387产 地：中国大陆
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T74383TLR4-IN-C34-C2-amide-C6-OH；化合物 TLR4-IN-C34-C2-amide-C6-OHTLR4-IN-C34-C2-amide-C6-OH
TLR4-IN-C34-C2-amide-C6-OH, a chemical compound, serves as a linker encompassing the TLR4 inhibitor TLR4-IN-C34. This inhibitor is known to target TLR4 in enterocytes and macrophages, effectively reducing systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis [1].
价 格：￥电议型 号：T74383产 地：中国大陆
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T74332Rifasutenizol；化合物 RifasutenizolRifasutenizol
Rifasutenizol (TNP-2198) is an orally bioavailable, dual-targeted antibacterial agent with potent effectiveness against both microaerophilic and anaerobic bacterial pathogens [1].
价 格：￥电议型 号：T74332产 地：中国大陆
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T7347CU-CPT-8m；化合物CU-CPT-8mTLR8-specific antagonist；TLR8-specific antagonist
CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
价 格：￥电议型 号：T7347产 地：中国大陆
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T73305ALR2-IN-3；化合物 ALR2-IN-3ALR2-IN-3
ALR2-IN-2, a potent aldose reductase (ALR2) inhibitor, demonstrates IC50 values of 22 nM for rat ALR2 and 116 nM for ALR1, respectively. This compound is utilized in diabetic complications research.
价 格：￥电议型 号：T73305产 地：中国大陆
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T73304ALR2-IN-2；化合物 ALR2-IN-2ALR2-IN-2
ALR2-IN-2, a potent aldose reductase (ALR2) inhibitor, exhibits IC50 values of 27 nM for rat ALR2 and 228 nM for ALR1, respectively. This compound is utilized in the research of diabetic complications.
价 格：￥电议型 号：T73304产 地：中国大陆
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T73176LRRK2-IN-7；化合物 LRRK2-IN-7LRRK2-IN-7
LRRK2-IN-7 is a potent LRRK2 kinase inhibitor that demonstrates high selectivity and central nervous system (CNS) penetration, possessing an IC50 value of 0.9 nM. It exhibits more than 1000-fold selectivity against a broad range of kinases, ion channels, and CYP enzymes.
价 格：￥电议型 号：T73176产 地：中国大陆
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T73034NLRP3-IN-12；化合物 NLRP3-IN-12NLRP3-IN-12
NLRP3-IN-12 is a specific inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release by targeting the NLRP3 protein, and demonstrating an IC50 of 0.45 μM. This compound is utilized in the research of inflammatory bowel disease.
价 格：￥电议型 号：T73034产 地：中国大陆
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T7302CU-CPT9b；化合物CU-CPT9bCU-CPT-9b|||TLR8-specific antagonist 1；CU-CPT-9b|||TLR8-specific antagonist 1
CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.
价 格：￥电议型 号：T7302产 地：中国大陆
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T73018NLRP3-IN-13；化合物 NLRP3-IN-13NLRP3-IN-13
NLRP3-IN-13 is a selective and potent inhibitor of NLRP3 (IC 50: 2.1 μM), capable of inhibiting both NLRP3 and NLRC4 inflammasomes as well as NLRP3-mediated IL-1β production. Furthermore, NLRP3-IN-13 suppresses NLRP3 ATPase activity. This compound is utilized in research focused on neuroinflammatory disorders.
价 格：￥电议型 号：T73018产 地：中国大陆
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T73015NLRP3-IN-16；化合物 NLRP3-IN-16NLRP3-IN-16
NLRP3-IN-16 is a potent, selective inhibitor of the NLRP3 inflammasome, effectively reducing IL-1β release with an IC50 of 0.065 μM, and is primarily utilized in inflammation research [1].
价 格：￥电议型 号：T73015产 地：中国大陆
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T73014NLRP3-IN-15；化合物 NLRP3-IN-15NLRP3-IN-15
NLRP3-IN-15 is a potent, selective inhibitor of the NLRP3 inflammasome, demonstrating efficacy by inhibiting IL-1β (interleukin-1 beta) release with an IC50 value of 0.114 μM. This compound is utilized in the research of inflammation.
价 格：￥电议型 号：T73014产 地：中国大陆
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T73013NLRP3-IN-14；化合物 NLRP3-IN-14NLRP3-IN-14
NLRP3-IN-14 is a potent, selective inhibitor of the NLRP3 inflammasome, displaying a dissociation constant (K D) of 5.87 μM and an IC50 of 0.131 μM for inhibiting IL-1β release. It is applicable for inflammation research.
价 格：￥电议型 号：T73013产 地：中国大陆
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T72830TLR8 agonist 5；化合物 TLR8 agonist 5TLR8 agonist 5
TLR8 Agonist 5, exhibiting potent efficacy as a TLR8 agonist, demonstrates an EC50 of 20 nM in HEK-Blue hTLR8, effectively activating the immune response.
价 格：￥电议型 号：T72830产 地：中国大陆
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T72684TLR7/8 agonist 7；化合物 TLR7/8 agonist 7TLR7/8 agonist 7
TLR7/8 agonist 7, a compound that functions as a TLR7/8 agonist, plays a pivotal role in activating various immune cells and is instrumental in the synthesis of immune-stimulating antibody conjugate (ISAC) molecules. This compound holds significant potential for research in immunology.
价 格：￥电议型 号：T72684产 地：中国大陆
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T72421LRRK2/NUAK1/TYK2-IN-1；化合物 LRRK2/NUAK1/TYK2-IN-1LRRK2/NUAK1/TYK2-IN-1
LRRK2/NUAK1/TYK2-IN-1 (compound 226) exhibits inhibitory activity against LRRK2 (Wt), LRRK2 (G2019), TYK2, and NUAK1, demonstrating IC50 values below 10 nM. This compound is useful for research into autoimmune diseases.
价 格：￥电议型 号：T72421产 地：中国大陆
