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T15286Flindokalner；化合物FlindokalnerBMS-204352；BMS-204352
Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) positive modulator. Flindokalner displays a negative modulatory activity at Kv7.1 channels (Ki=3.7 μM) and acts as a negative modulator of GABAA receptors and it also shows anxiolytic efficacy in vivo.
价 格：￥电议型 号：T15286产 地：中国大陆
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T15246Esaxerenone；艾沙利酮XL-550|||CS-3150；艾沙利酮|||XL-550|||CS-3150
Esaxerenone (XL-550) is a highly potent and selective non-steroidal antagonist of the mineralocorticoid receptor.
价 格：￥电议型 号：T15246产 地：中国大陆
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T15169DS-437；化合物 T15169DS-437
DS-437 is a dual PRMT5/7 inhibitor (IC50s: 6 μM). DS-437 also inhibits DNMT3A and DNMT3B (IC50s: 52 and 62 μM). DS-437 inhibits the methylation of FOXP3.
价 格：￥电议型 号：T15169产 地：中国大陆
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T15076DBCO-S-S-PEG3-biotin生物素-PEG3-二硫-DBCO生物素-PEG3-二硫-DBCO
DBCO-S-S-PEG3-biotin is a cleavable reagent for introduction of a biotin moiety to azide-containing biomolecules using copper-free Click Chemistry. The disulfide bond in this linker can be cleaved using reducing agents such as DTT, BME and TCEP to remove the biotin label. PEG Linkers can be used in the synthesis of PROTACs.
价 格：￥电议型 号：T15076产 地：中国大陆
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T15047Dacisteine；达西司坦N,S-Diacetyl-L-cysteine；N,S-Diacetyl-L-cysteine|||达西司坦
Dacisteine (N,S-Diacetyl-L-cysteine) is an inhibitor of New Delhi metallo-beta-lactamase-1 (NDM-1, IC50 = 1000 μM).
价 格：￥电议型 号：T15047产 地：中国大陆
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T15015CTS-1027；化合物 T15015RS 130830|||Ro 1130830；RS 130830|||Ro 1130830
CTS-1027 is a small molecule inhibitor of MMPs (IC50s: 0.3 nM, 0.5 nM for MMP2, MMP13). It has > 1,000 fold selectivity over MMP1.
价 格：￥电议型 号：T15015产 地：中国大陆
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T14991CMS-121；化合物CMS-121CMS121；CMS121
CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities.
价 格：￥电议型 号：T14991产 地：中国大陆
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T14967Cimlanod；化合物 T14967BMS-986231|||CXL-1427；BMS-986231|||CXL-1427
Cimlanod is a second-generation Nitroxyl (HNO) donor for heart failure with positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloodstream.
价 格：￥电议型 号：T14967产 地：中国大陆
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T14925Cenisertib；化合物 T14925AS-703569|||R-763；AS-703569|||R-763
Cenisertib is A potent ATP-competitive multi-kinase inhibitor, showing inhibitory effects on the activity of Aurora-kinase-A/B, ABL1, AKT, STAT5, FLT3, as well as kinase inhibitors of FER and its homolog. Cenisertib inhibits the growth of tumor mast cells (MCS) by inhibiting the activity of several different molecular targets. Cenisertib also inhibits tumor growth in pancreatic, breast, colon, ovarian and lung cancer and leukemia in xenograft models.
价 格：￥电议型 号：T14925产 地：中国大陆
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T14851C2-Bis-phosphoramidic acid diethyl ester；化合物 T14851C2-Bis-phosphoramidic acid diethyl ester
C2-Bis-phosphoramidic acid diethyl ester is an alkyl chain-derived PROTAC linker utilized for the synthesis of PROTACs[1].
价 格：￥电议型 号：T14851产 地：中国大陆
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T14850C-NH-Boc-C-Bis-(C1-PEG1-PFP)；化合物 T14850C-NH-Boc-C-Bis-(C1-PEG1-PFP)
C-NH-Boc-C-Bis-(C1-PEG1-PFP) is a polyethylene glycol (PEG)-derived PROTAC linker, which finds application in the synthesis of PROTACs[1].
价 格：￥电议型 号：T14850产 地：中国大陆
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T14849C-NH-Boc-C-Bis-(C-PEG1-Boc)；化合物 T14849C-NH-Boc-C-Bis-(C-PEG1-Boc)
C-NH-Boc-C-Bis-(C-PEG1-Boc) is a versatile alkyl/ether-based PROTAC linker for synthesizing PROTACs[1].
价 格：￥电议型 号：T14849产 地：中国大陆
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T14765BOS-172722；化合物BOS-172722BOS-172722
BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).
价 格：￥电议型 号：T14765产 地：中国大陆
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T14733Boc-NH-ethyl-SS-propionic acid；化合物 T14733Boc-NH-ethyl-SS-propionic acid
Boc-NH-ethyl-SS-propionic acid is an ADC linker compound employed for the synthesis of antibody-drug conjugates (ADCs)[1].
价 格：￥电议型 号：T14733产 地：中国大陆
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T14705Boc-aminooxy-ethyl-SS-propanol；化合物 T14705Boc-aminooxy-ethyl-SS-propanol
Boc-aminooxy-ethyl-SS-propanol is a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs)[1].
价 格：￥电议型 号：T14705产 地：中国大陆
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T14690BMS 433796；化合物BMS 433796BMS-289948|||BMS-299897；BMS-289948|||BMS-299897
BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer´s disease.
价 格：￥电议型 号：T14690产 地：中国大陆
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T14689BMS493；化合物 BMS493BMS-493；BMS-493
BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with RARs, attenuates RA signaling, potentiates TPP-induced toxicity, and inhibits the increase in phospholipase A2 activity.
价 格：￥电议型 号：T14689产 地：中国大陆
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T14687Deucravacitinib；化合物BMS-986165BMS-986165；BMS-986165
Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain.
价 格：￥电议型 号：T14687产 地：中国大陆
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T14686BMS-986163；化合物 T14686BMS-986163
BMS-986163 is a negative allosteric modulator of GluN2B and the prodrug BMS-986163 rapidly converts to its active parent molecule BMS-986169 (Ki=4 nM, IC50=24 nM).
价 格：￥电议型 号：T14686产 地：中国大陆
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T14685BMS-986158；化合物BMS-986158BMS-986158
BMS-986158 is a highly effective BET inhibitor, demonstrating IC50 values of 6.6 nM in NCI-H211 small cell lung cancer (SCLC) cells and 5 nM in MDA-MB231 triple negative breast cancer (TNBC) cells.
价 格：￥电议型 号：T14685产 地：中国大陆
