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  • T14684BMS-986120；化合物 T14684BMS-986120

    BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist. With IC50s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects[1][2].

    价 格：￥电议型 号：T14684产 地：中国大陆

  • T14683BMS-983970；化合物 T14683BMS-983970

    BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.

    价 格：￥电议型 号：T14683产 地：中国大陆

  • T14682BMS-962212；化合物 T14682BMS-962212

    BMS-962212, a direct, reversible, and selective factor XIa (FXIa) inhibitor, demonstrates fast pharmacodynamic (PD) response onset and rapid elimination with a well-tolerated profile. It dependently increases activated partial thromboplastin time and decreases FXI clotting activity exposure [1].

    价 格：￥电议型 号：T14682产 地：中国大陆

  • T14681BMS-935177；化合物BMS-935177BMS-935177

    BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.

    价 格：￥电议型 号：T14681产 地：中国大陆

  • T14680BMS-906024；化合物 BMS-906024Osugacestat|||AL-101|||BM-0018；Osugacestat|||AL-101|||BM-0018

    BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively.

    价 格：￥电议型 号：T14680产 地：中国大陆

  • T14678BMS-819881；化合物 T14678BMS-819881

    BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A4 activity with an EC50 of 13 μM.

    价 格：￥电议型 号：T14678产 地：中国大陆

  • T14677BMS-690514；化合物BMS-690514BMS-690514

    BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.

    价 格：￥电议型 号：T14677产 地：中国大陆

  • T14676BMS-688521化合物 BMS-688521BMS688521|||BMS 688521

    BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity.

    价 格：￥电议型 号：T14676产 地：中国大陆

  • T14675BMS-564929；化合物 T14675BMS-564929

    BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).

    价 格：￥电议型 号：T14675产 地：中国大陆

  • T14674BMS-509744；化合物 T14674BMS-509744

    BMS-509744 is an inhibitor of ATP competitive Itk (IC50: 19 nM).

    价 格：￥电议型 号：T14674产 地：中国大陆

  • T14672BMS-248360；化合物 T14672BMS-248360

    BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor. With Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 shows hypertensive effects[1].

    价 格：￥电议型 号：T14672产 地：中国大陆

  • T14671BMS-193885；化合物BMS-193885BMS-193885

    BMS-193885 is a selective, brain-penetrant, and competitive antagonist of the neuropeptide Y1 receptor with a Ki of 3.3 nM, and an IC50 of 5.9 nM for hY1.

    价 格：￥电议型 号：T14671产 地：中国大陆

  • T14670BMS-1166 hydrochloride；化合物 T14670BMS-1166 hydrochloride

    Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM). BMS-1166 hydrochloride is an inhibitor of PD-1/PD-L1 interaction (IC50: 1.4 nM). BMS-1166 rivalries the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.

    价 格：￥电议型 号：T14670产 地：中国大陆

  • T14669BMS-066；化合物 T14669BMS-066

    BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.

    价 格：￥电议型 号：T14669产 地：中国大陆

  • T14663Bis-Tos-(2-hydroxyethyl disulfide)；化合物 T14663Bis-Tos-(2-hydroxyethyl disulfide)

    Bis-Tos-(2-hydroxyethyl disulfide) is a cleavable linker employed in the synthesis of antibody-drug conjugates (ADCs)[1].

    价 格：￥电议型 号：T14663产 地：中国大陆

  • T14662Bis-propargyl-PEG9；化合物 T14662Bis-propargyl-PEG9

    Bis-propargyl-PEG9 is a PEG-based PROTAC linker employed in the synthesis of PROTACs. It is specifically utilized to synthesize the bivalent ligands of estrogen receptor[1].

    价 格：￥电议型 号：T14662产 地：中国大陆

  • T14661Bis-propargyl-PEG8；化合物 T14661Bis-propargyl-PEG8

    Bis-propargyl-PEG8 (compound 16e) is a polyethylene glycol (PEG)-based linker that is employed in the synthesis of proteolysis targeting chimeras (PROTACs).

    价 格：￥电议型 号：T14661产 地：中国大陆

  • T14660Bis-propargyl-PEG7；化合物 T14660Bis-propargyl-PEG7

    Bis-propargyl-PEG7 is a polyethylene glycol (PEG)-based linker utilized in the synthesis of proteolysis targeting chimeras (PROTACs). It is particularly employed for the synthesis of polymer-linked multimers of guanosine-3´,5´-cyclic monophosphates[1].

    价 格：￥电议型 号：T14660产 地：中国大陆

  • T14659Bis-propargyl-PEG6；化合物 T14659Bis-propargyl-PEG6

    Bis-propargyl-PEG6 is a polyethylene glycol (PEG) derivative commonly employed as a PEG-based PROTAC linker during the synthesis of PROTACs. Its application includes the generation of polymer-linked multimers of guanosine-3´, 5´-cyclic monophosphates[1].

    价 格：￥电议型 号：T14659产 地：中国大陆

  • T14658Bis-propargyl-PEG5；化合物 T14658Bis-propargyl-PEG5

    Bis-propargyl-PEG5 serves as a PEG-based PROTAC linker, facilitating the synthesis of PROTACs. This chemical compound is particularly employed in the synthesis of carbohydrate receptors (SCRs) with anti-Zika activity[1].

    价 格：￥电议型 号：T14658产 地：中国大陆

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