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T1788Tazemetostat;化合物EPZ6438E-7438|||EPZ6438;E-7438|||EPZ6438
Tazemetostat (EPZ6438) is a histone methyltransferase EZH2 inhibitor (IC50=11 nM) that is orally active, selective, and SAM-competitive. Tazemetostat exhibits antitumor activity and may be used for the treatment of epithelioid sarcoma/follicular lymphoma.
价 格:¥电议型 号:T1788产 地:中国大陆
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T17843DOTA-PEG5-amine;化合物 T17843DOTA-PEG5-amine
DOTA-PEG5-amine is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T17843产 地:中国大陆
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T1782LCanagliflozin hemihydrate;卡格列净半水合物JNJ28431754|||TA 7284|||TA7284|||TA-7284|||JNJ 28431754|||JNJ-2843
Canagliflozin hemihydrate (TA 7284) is a drug of the gliflozin class or subtype 2 sodium-glucose transport inhibitors used for the treatment of type 2 diabetes. SGLT2 is responsible for at least 90% of renal glucose reabsorption (SGLT1 being responsible for the remaining 10%). Blocking this transporter causes up to 119 grams of blood glucose per day to be eliminated through the urine, corresponding to 476 kilocalories.
价 格:¥电议型 号:T1782L产 地:中国大陆
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T1782Canagliflozin;卡格列净JNJ 24831754ZAE|||JNJ 28431754AAA|||TA 7284|||JNJ 28431754;卡格列净|||JNJ 24831754ZAE|
Canagliflozin (JNJ 28431754AAA), a sodium-glucose transporter 2( SGLT2) and P-Glycoprotein inhibitor, is used in type 2 diabetes.
价 格:¥电议型 号:T1782产 地:中国大陆
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T17743DBCO-C-PEG1;化合物 T17743DBCO-C-PEG1
DBCO-C-PEG1 is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T17743产 地:中国大陆
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T17643Boc-Aminooxy-PEG4-CH2-Boc;化合物 T17643Boc-Aminooxy-PEG4-CH2-Boc
Boc-Aminooxy-PEG4-CH2-Boc is a PEG-based linker utilized in the synthesis of PROTACs.
价 格:¥电议型 号:T17643产 地:中国大陆
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T17543BI-3663;化合物 T17543BI-3663
BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer activity[1].
价 格:¥电议型 号:T17543产 地:中国大陆
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T17443Amino-SS-PEG12-acid;化合物 T17443Amino-SS-PEG12-acid
Amino-SS-PEG12-acid, a cleavable 12-unit polyethylene glycol (PEG) linker, is commonly used in the synthesis of antibody-drug conjugates (ADCs)[1].
价 格:¥电议型 号:T17443产 地:中国大陆
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T17439Amino-PEG6-Thalidomide;化合物 T17439Amino-PEG6-Thalidomide
Amino-PEG6-Thalidomide is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T17439产 地:中国大陆
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T17438Amino-PEG6-amido-C16-COOH;化合物 T1743817-(Amino-PEG6-ethylcarbamoyl)heptadecanoic acid;17-(Amino-PEG6-
Amino-PEG6-amido-C16-COOH, a PEG-based PROTAC linker, facilitates the synthesis of PROTACs[1].
价 格:¥电议型 号:T17438产 地:中国大陆
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T17437Amino-PEG6-amido-C16-Boc;化合物 T1743717-(Amino-PEG6-ethylcarbamoyl)heptadecanoic t-butyl ester;17-(Ami
Amino-PEG6-amido-C16-Boc is a PEG-based PROTAC linker employed for the synthesis of PROTACs[1].
价 格:¥电议型 号:T17437产 地:中国大陆
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T17436Amino-PEG6-amido-bis-PEG5-N3;化合物 T17436Amino-PEG6-amido-bis-PEG5-N3
Amino-PEG6-amido-bis-PEG5-N3 is a cleavable 11-unit polyethylene glycol (PEG) linker that finds application in the synthesis of antibody-drug conjugates (ADCs) [1].
价 格:¥电议型 号:T17436产 地:中国大陆
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T17435Amino-PEG4-Val-Cit-PAB-MMAE;化合物 T17435Amino PEG4 Val Cit PAB MMAE|||Amino-PEG-4-Val-Cit-PAB-MMAE|||A
Amino-PEG4-Val-Cit-PAB-MMAE is a cleavable tetraethylene glycol (4 unit PEG) antibody-drug conjugate (ADC) linker employed in the synthesis of ADCs[1].
价 格:¥电议型 号:T17435产 地:中国大陆
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T17434Amino-PEG4-benzyl ester;化合物 T17434Amino-PEG4-benzyl ester
Amino-PEG4-benzyl ester, a PEG- and Alkyl/ether-based PROTAC linker, serves as a valuable component for the synthesis of PROTACs[1].
价 格:¥电议型 号:T17434产 地:中国大陆
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T17433Amino-PEG36-CONH-PEG36-acid;化合物 T17433Amino-PEG36-CONH-PEG36-acid
Amino-PEG36-CONH-PEG36-acid is a polyethylene glycol (PEG)-based linker with amino and carboxylic acid functionalities. It finds utility in the synthesis of proteolysis targeting chimeras (PROTACs)[1].
价 格:¥电议型 号:T17433产 地:中国大陆
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T17432Amino-PEG36-CH2-Boc;化合物 T17432Amino-PEG36-CH2-Boc
Amino-PEG36-CH2-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T17432产 地:中国大陆
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T17431Amino-PEG36-Boc;化合物 T17431Amino-PEG36-Boc
Amino-PEG36-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T17431产 地:中国大陆
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T17430Amino-PEG36-alcohol;化合物 T17430Amino-PEG36-alcohol
Amino-PEG36-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T17430产 地:中国大陆
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T1743Aprepitant;阿瑞匹坦MK-869|||MK-0869|||L-754030|||Aprepitant`;MK-869|||MK-0869|||阿瑞匹坦|||L-754030|||Aprepi
Aprepitant (Aprepitant`) is a Substance P/Neurokinin-1 Receptor Antagonist. The mechanism of action of aprepitant is as a Neurokinin 1 Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 2C9 Inducer, and Cytochrome P450 3A4 Inducer.
价 格:¥电议型 号:T1743产 地:中国大陆
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T173437-O-(Amino-PEG4)-paclitaxel;化合物 T173437-O-(Amino-PEG4)-paclitaxel
7-O-(Amino-PEG4)-paclitaxel is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格:¥电议型 号:T17343产 地:中国大陆