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T14682BMS-962212；化合物 T14682BMS-962212
BMS-962212, a direct, reversible, and selective factor XIa (FXIa) inhibitor, demonstrates fast pharmacodynamic (PD) response onset and rapid elimination with a well-tolerated profile. It dependently increases activated partial thromboplastin time and decreases FXI clotting activity exposure [1].
价 格：￥电议型 号：T14682产 地：中国大陆
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T14681BMS-935177；化合物BMS-935177BMS-935177
BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.
价 格：￥电议型 号：T14681产 地：中国大陆
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T14680BMS-906024；化合物 BMS-906024Osugacestat|||AL-101|||BM-0018；Osugacestat|||AL-101|||BM-0018
BMS-906024 (Osugacestat) is an orally available and selective inhibitor of γ-secretase, a small molecule Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity against a variety of human cancer xenografts.BMS-906024 prevents the activation of all four Notch receptors, and is active against Notch1, -2, -3 and -4 receptors. BMS-906024 prevents the activation of all four Notch receptors, with IC50s of 1.6, 0.7, 3.4 and 2.9 nM for Notch1, -2, -3 and -4 receptors, respectively.
价 格：￥电议型 号：T14680产 地：中国大陆
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T1468Lornoxicam；氯诺昔康Ro 13-9297|||Chlortenoxicam|||TS110；Ro 13-9297|||Chlortenoxicam|||TS110|||氯诺昔康
Lornoxicam (Chlortenoxicam) (chlortenoxicam) is a new nonsteroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic, anti-inflammatory, and antipyretic properties. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug. Lornoxicam is approved for use in Japan.
价 格：￥电议型 号：T1468产 地：中国大陆
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T14678BMS-819881；化合物 T14678BMS-819881
BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM and it also is selective and potent for CYP3A4 activity with an EC50 of 13 μM.
价 格：￥电议型 号：T14678产 地：中国大陆
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T14677BMS-690514；化合物BMS-690514BMS-690514
BMS-690514 is a potent and orally active inhibitor of EGFR and VEGFR. It has IC50s of 5, 20 and 60 nM for EGFR, HER 2 and HER 4, respectively.
价 格：￥电议型 号：T14677产 地：中国大陆
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T14676BMS-688521化合物 BMS-688521BMS688521|||BMS 688521
BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity.
价 格：￥电议型 号：T14676产 地：中国大陆
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T14675BMS-564929；化合物 T14675BMS-564929
BMS-564929 is an agonist of androgen receptor (AR, Ki of 2.11±0.16 nM).
价 格：￥电议型 号：T14675产 地：中国大陆
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T14674BMS-509744；化合物 T14674BMS-509744
BMS-509744 is an inhibitor of ATP competitive Itk (IC50: 19 nM).
价 格：￥电议型 号：T14674产 地：中国大陆
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T14673BMS 299897；化合物BMS 299897BMS 299897
BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).
价 格：￥电议型 号：T14673产 地：中国大陆
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T14672BMS-248360；化合物 T14672BMS-248360
BMS-248360 is a potent and orally active dual antagonist of both angiotensin II receptor (AT1) and endothelin A (ETA) receptor. With Kis of 10 nM and 1.9 nM for hAT1 and hETA receptor, respectively. BMS-248360 shows hypertensive effects[1].
价 格：￥电议型 号：T14672产 地：中国大陆
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T14671BMS-193885；化合物BMS-193885BMS-193885
BMS-193885 is a selective, brain-penetrant, and competitive antagonist of the neuropeptide Y1 receptor with a Ki of 3.3 nM, and an IC50 of 5.9 nM for hY1.
价 格：￥电议型 号：T14671产 地：中国大陆
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T14670BMS-1166 hydrochloride；化合物 T14670BMS-1166 hydrochloride
Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM). BMS-1166 hydrochloride is an inhibitor of PD-1/PD-L1 interaction (IC50: 1.4 nM). BMS-1166 rivalries the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
价 格：￥电议型 号：T14670产 地：中国大陆
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T1467Acemetacin阿西美辛阿西美辛|||K-708|||TVX 1322
Acemetacin (TVX 1322) is a carboxymethyl ester of indometacin. It is a potent non-steroidal anti-inflammatory drug, derived from the indol-3-acetic acid, whose activity is thought to be mainly through its active metabolite indomethacin. In clinical trials, acemetacin exhibits a better gastric tolerability compared to its active metabolite indometacin.
价 格：￥电议型 号：T1467产 地：中国大陆
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T1466LDifloxacin HCl；化合物 T1466LDifloxacin HCl
Difloxacin is a second-generation, synthetic fluoroquinolone antimicrobial antibiotic.
价 格：￥电议型 号：T1466L产 地：中国大陆
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T14669BMS-066；化合物 T14669BMS-066
BMS-066 is an IKKβ/Tyk2 pseudokinase inhibitor. With IC50s of 9 nM and 72 nM, respectively.
价 格：￥电议型 号：T14669产 地：中国大陆
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T14668BMPS；化合物 T14668BMPS
BMPS, a non-cleavable ADC linker, is utilized in the synthesis of antibody-drug conjugates (ADCs).
价 格：￥电议型 号：T14668产 地：中国大陆
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T14667BLT-1；化合物BLT-1BLT-1
BLT-1 is a scavenger receptor BI (SR-BI)inhibitor.
价 格：￥电议型 号：T14667产 地：中国大陆
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T14666BL-1249；化合物BL-1249BL-1249
BL-1249 is a selective and potent non-steroidal potassium channel activator with anti-inflammatory activity that activates K2P2.1 (TREK-1) and K2P10.1 (TREK-2).
价 格：￥电议型 号：T14666产 地：中国大陆
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T14665LMotixafortide TFA(664334-36-5,Free)；化合物Motixafortide TFATF 14016 TFA|||BKT140 TFA|||BL-8040 TFA|||T1
Motixafortide TFA(664334-36-5,Free) (BKT140 TFA) is an antagonist of CXCR4 with IC50 of ～1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via altered miR-15a/16-1 expression.
价 格：￥电议型 号：T14665L产 地：中国大陆
