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T14846Bz 423化合物Bz 423BZ48
Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus.
价 格：￥电议型 号：T14846产 地：中国大陆
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T14746Boc-NH-PEG4-CH2COOHN-叔丁氧羰基-四聚乙二醇-乙酸N-叔丁氧羰基-四聚乙二醇-乙酸
Boc-NH-PEG4-CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC)[1].
价 格：￥电议型 号：T14746产 地：中国大陆
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T14699BnO-PEG4-OH；化合物 T14699BnO-PEG4-OH
BnO-PEG4-OH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T14699产 地：中国大陆
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T14698BnO-PEG4-Boc；化合物 T14698BnO-PEG4-Boc
BnO-PEG4-Boc is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T14698产 地：中国大陆
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T14697BnO-PEG1-CH2COOH；化合物 T14697BnO-PEG1-CH2COOH
BnO-PEG1-CH2COOH is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T14697产 地：中国大陆
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T14696BnO-PEG1-CH2CO2tBu；化合物 T14696BnO-PEG1-CH2CO2tBu
BnO-PEG1-CH2CO2tBu is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T14696产 地：中国大陆
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T14695BNC375；化合物 T14695BNC375
BNC375 is a α7 nAChRs type I positive allosteric modulator (EC50: 1.9 μM).
价 格：￥电议型 号：T14695产 地：中国大陆
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T14694BNC105；化合物BNC105BNC105
BNC105 is a tubulin polymerization inhibitor. It has potent antiproliferative and tumor vascular disrupting properties.
价 格：￥电议型 号：T14694产 地：中国大陆
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T14693BN201；化合物 T14693BN201
BN201, a chemical compound, actively crosses the blood-brain barrier and activates the IGF-1 pathway, which is associated with stress response and neuron survival. It facilitates neuronal differentiation and the maturation of precursor cells into oligodendrocytes with an EC50 of 6.3 μM, in addition to promoting the myelination of new axons with an EC50 of 16.6 μM in vitro. BN201 exhibits potent neuroprotective effects[1].
价 格：￥电议型 号：T14693产 地：中国大陆
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T14692BMX-IN-1；化合物BMX-IN-1BMX kinase inhibitor；BMX kinase inhibitor
BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
价 格：￥电议型 号：T14692产 地：中国大陆
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T14691BMT-090605；化合物 T14691BMT-090605
BMT-090605 is a potent, selective AAK1 inhibitor, with an IC50 of 0.6 nM. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 45 and 60 nM, respectively[1]. BMT-090605 shows antinociceptive activity.
价 格：￥电议型 号：T14691产 地：中国大陆
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T14690BMS 433796；化合物BMS 433796BMS-289948|||BMS-299897；BMS-289948|||BMS-299897
BMS 433796 is a γ-secretase inhibitor that demonstrates Aβ-lowering activity within a transgenic mouse model of Alzheimer´s disease.
价 格：￥电议型 号：T14690产 地：中国大陆
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T1469Levocetirizine；左西替利嗪Levocetirizine HCl；Levocetirizine HCl|||左西替利嗪
Levocetirizine is a Histamine-1 Receptor Antagonist. The mechanism of action of levocetirizine is as a Histamine H1 Receptor Antagonist.
价 格：￥电议型 号：T1469产 地：中国大陆
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T14689BMS493；化合物 BMS493BMS-493；BMS-493
BMS493 is an inverse agonist of the pan-retinoic acid receptor (RAR) that inhibits retinoic acid-induced differentiation, enhances the interaction of nuclear co-inhibitors with RARs, attenuates RA signaling, potentiates TPP-induced toxicity, and inhibits the increase in phospholipase A2 activity.
价 格：￥电议型 号：T14689产 地：中国大陆
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T14688BMS CCR2 22；化合物BMS CCR2 22BMS CCR2 22
BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.
价 格：￥电议型 号：T14688产 地：中国大陆
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T14687Deucravacitinib；化合物BMS-986165BMS-986165；BMS-986165
Deucravacitinib (BMS-986165) inhibits IL-12/23 and type I IFN pathways[1][2]. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain.
价 格：￥电议型 号：T14687产 地：中国大陆
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T14686BMS-986163；化合物 T14686BMS-986163
BMS-986163 is a negative allosteric modulator of GluN2B and the prodrug BMS-986163 rapidly converts to its active parent molecule BMS-986169 (Ki=4 nM, IC50=24 nM).
价 格：￥电议型 号：T14686产 地：中国大陆
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T14685BMS-986158；化合物BMS-986158BMS-986158
BMS-986158 is a highly effective BET inhibitor, demonstrating IC50 values of 6.6 nM in NCI-H211 small cell lung cancer (SCLC) cells and 5 nM in MDA-MB231 triple negative breast cancer (TNBC) cells.
价 格：￥电议型 号：T14685产 地：中国大陆
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T14684BMS-986120；化合物 T14684BMS-986120
BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist. With IC50s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects[1][2].
价 格：￥电议型 号：T14684产 地：中国大陆
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T14683BMS-983970；化合物 T14683BMS-983970
BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.
价 格：￥电议型 号：T14683产 地：中国大陆
