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  • T78783HBV-IN-35；化合物 HBV-IN-35HBV-IN-35

    Compound HBV-IN-35 (Compound 88) serves as an HBV inhibitor and exhibits anti-HBV activity in both mouse and human hepatocytes with EC50 values of 100 nM and 400 nM, respectively [1].

    价 格：￥电议型 号：T78783产 地：中国大陆

  • T78776DNA gyrase B-IN-3；化合物 DNA gyrase B-IN-3DNA gyrase B-IN-3

    DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram-positive strains [1].

    价 格：￥电议型 号：T78776产 地：中国大陆

  • T78755PD-1/PD-L1-IN-31；化合物 PD-1/PD-L1-IN-31PD-1/PD-L1-IN-31

    PD-1/PD-L1-IN-31 is a potent inhibitor of PD-1/PD-L1 (IC50=2.2 nM) that enhances IFN-γ secretion and activates the immune response of peripheral blood mononuclear cells (PBMCs), resulting in the inhibition of tumor cells [1].

    价 格：￥电议型 号：T78755产 地：中国大陆

  • T78754COX-2-IN-33；化合物 COX-2-IN-33COX-2-IN-33

    COX-2-IN-33 (compound 5f) is a selective COX-2 inhibitor with an IC50 value of 45.5 nM and exhibits potential as an anti-inflammatory agent. It effectively suppresses pro-inflammatory cytokine production in vivo while maintaining gastric safety [1].

    价 格：￥电议型 号：T78754产 地：中国大陆

  • T78746Mtb-IN-3；化合物 Mtb-IN-3Mtb-IN-3

    Mtb-IN-3 (compound 10c), a selective and potent Mycobacterium tuberculosis (Mtb) inhibitor, exhibits strong antimycobacterial activity in vitro without inducing cytotoxic effects and inhibits colony formation in the spleen in murine tuberculosis models [1].

    价 格：￥电议型 号：T78746产 地：中国大陆

  • T78737NNRTIs-IN-3；化合物 NNRTIs-IN-3NNRTIs-IN-3

    NNRTIs-IN-3 (compound 8) is an HIV-1 non-nucleoside reverse transcriptase inhibitor, displaying potent efficacy with an EC50 value of 0.01 ?M [1].

    价 格：￥电议型 号：T78737产 地：中国大陆

  • T78725SARS-CoV-2 nsp14-IN-3；化合物 SARS-CoV-2 nsp14-IN-3SARS-CoV-2 nsp14-IN-3

    SARS-CoV-2 nsp14-IN-3 (4975) is a potent inhibitor targeting the N7-Methyltransferase activity of SARS-CoV-2 nonstructural protein 14 (Nsp14), with an IC50 value of 3.5 μM [1].

    价 格：￥电议型 号：T78725产 地：中国大陆

  • T78706COX-2-IN-31；化合物 COX-2-IN-31COX-2-IN-31

    COX-2-IN-31 (compound 7b) is an orally active dual inhibitor targeting COX-2 (IC50=60 nM) and 5-LOX (IC50=1.9 μM). Additionally, it inhibits the activity of transmembrane hCA IX (Ki=48.9 nM) and hCA XII (Ki=5.8 nM). This compound demonstrates anti-inflammatory and analgesic activity [1].

    价 格：￥电议型 号：T78706产 地：中国大陆

  • T78705COX-2-IN-30；化合物 COX-2-IN-30COX-2-IN-30

    COX-2-IN-30, a benzenesulfonamide derivative, is an orally active, dual inhibitor of cyclooxygenase-2 (COX-2; IC50 = 49 nM) and cyclooxygenase-1 (COX-1; IC50 = 10.4 μM), as well as 5-lipoxygenase (5-LOX; IC50 = 2.4 μM). Additionally, it inhibits the transmembrane isoforms of human carbonic anhydrase IX and XII with nanomolar class Ki values. Demonstrating analgesic and anti-inflammatory properties, COX-2-IN-30 is devoid of acute gastric effects, avoiding ulcerogenic activity [1].

    价 格：￥电议型 号：T78705产 地：中国大陆

  • T78688HPK1-IN-35；化合物 HPK1-IN-35HPK1-IN-35

    HPK1-IN-35 is a potent, selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM. This compound reduces p-SLP76 expression and facilitates the secretion of IL-2 [1].

    价 格：￥电议型 号：T78688产 地：中国大陆

  • T78654MraY-IN-3 hydrochloride；化合物 MraY-IN-3 hydrochlorideMraY-IN-3 hydrochloride

    MraY-IN-1 (compound 12a) is a potent inhibitor of MraY, exhibiting an IC50 of 140 ?M. This compound demonstrates antimicrobial activity, with MIC50 values of 7 ?g/mL against Escherichia coli K12, 12 ?g/mL for Bacillus subtilis W23, and 46 ?g/mL in the case of Pseudomonas fluorescens Pf-5. MraY-IN-1 is utilized in anti-bacterial research [1].

    价 格：￥电议型 号：T78654产 地：中国大陆

  • T78653NS2B/NS3-IN-3 hydrochloride；化合物 NS2B/NS3-IN-3 hydrochlorideNS2B/NS3-IN-3 hydrochloride

    NS2B/NS3-IN-3 hydrochloride is a Flavivirus NS2B-NS3 protease inhibitor [1].

    价 格：￥电议型 号：T78653产 地：中国大陆

  • T78648MAO-B-IN-3；化合物 MAO-B-IN-3MAO-B-IN-3

    MAO-B-IN-3 is a reversible, selective inhibitor of monoamine oxidase B (MAO-B) with an IC50 of 96 nM and demonstrates affinity for the 5-HT6 receptor with a Ki of 696 nM, making it suitable for Alzheimer´s disease research [1].

    价 格：￥电议型 号：T78648产 地：中国大陆

  • T78604SLC26A3-IN-3；化合物 SLC26A3-IN-3SLC26A3-IN-3

    SLC26A3-IN-3 (compound 4az), a potent SLC26A3 inhibitor with an IC50 of 40 nM, is utilized for constipation and cystic fibrosis research [1].

    价 格：￥电议型 号：T78604产 地：中国大陆

  • T78597RIPK2-IN-3；化合物 RIPK2-IN-3RIPK2-IN-3

    RIPK2-IN-3 (FCG806791773) is a receptor-interacting protein kinase 2 (RIPK2) inhibitor with an IC50 value of 6.39 μM against recombinant truncated RIPK2. It is applicable in the study of inflammation and cancer [1].

    价 格：￥电议型 号：T78597产 地：中国大陆

  • T78559PDE7-IN-3；化合物 PDE7-IN-3PDE7-IN-3

    PDE7-IN-3 (Example 2) serves as an inhibitor of phosphodiesterase PDE7 and exhibits potential analgesic properties. It is applicable in the research of various pain types including inflammatory, neuropathic, visceral, and nociceptive pain [1].

    价 格：￥电议型 号：T78559产 地：中国大陆

  • T78232hMAO-B-IN-32；hMAO-B抑制剂32Ethyl 7-(diethylamino)-2-oxo-2H-chromene-3-carboxylate；Ethyl 7-(diethylamino

    hMAO-B-IN-32 is a potent hMAO-B selective inhibitor with an IC50 of 45.52 μM.

    价 格：￥电议型 号：T78232产 地：中国大陆

  • T78224Histatin-3；化合物 Histatin-3Histatin-3

    Histatin-3, a 32-amino-acid peptide, exhibits potent antimicrobial activities and serves as a substrate for proprotein convertase 1 (PC1), where it is primarily cleaved at a site carboxy-terminal to Arg25 (HRGYR↓SN). Additionally, it acts as a moderately potent, reversible, and competitive inhibitor of furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an inhibition constant (Ki) estimated at 1.98 μM [1].

    价 格：￥电议型 号：T78224产 地：中国大陆

  • T78187FOXO1-IN-3；化合物 FOXO1-IN-3FOXO1-IN-3

    FOXO1-IN-3 is a highly-selective, orally active inhibitor of FOXO1 that diminishes hepatic glucose production and enhances insulin sensitivity and glucose regulation in db/db mice, all without inducing weight gain [1].

    价 格：￥电议型 号：T78187产 地：中国大陆

  • T78173Aβ/tau aggregation-IN-3；化合物 Aβ/tau aggregation-IN-3Aβ/tau aggregation-IN-3

    Aβ/tau aggregation-IN-3 is a potent inhibitor of amyloid protein aggregation, exhibiting an IC50 value of 0.85 ?M in an Aβ-Thioflavin T (Aβ-ThT) functional aggregation assay. This compound demonstrates anti-amyloid activity [1].

    价 格：￥电议型 号：T78173产 地：中国大陆

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