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T1950PND-1186化合物PND-1186PND1186|||PND 1186|||VS-4718|||SR-2516
PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).
价 格：￥电议型 号：T1950产 地：中国大陆
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T18632PROTAC MDM2 Degrader-2；化合物 T18632PROTAC MDM2 Degrader-2
PROTAC MDM2 Degrader-2 is a compound designed utilizing PROTAC technology, functioning as a MDM2 degrader. Comprised of a highly potent inhibitor targeting MDM2, a linker, and the MDM2 ligand for E3 ubiquitin ligase, this compound facilitates the degradation of MDM2[1].
价 格：￥电议型 号：T18632产 地：中国大陆
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T18609PROTAC ERRα Degrader-2；化合物 T18609PROTAC ERRα Degrader-2
PROTAC ERRα Degrader-2 is a compound consisting of an MDM2 ligand binding group, a linker, and an estrogen-related receptor alpha (ERRα) binding group. This compound is designed to specifically degrade estrogen-related receptor alpha (ERRα), acting as an ERRα degrader[1].
价 格：￥电议型 号：T18609产 地：中国大陆
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T18606PROTAC ER Degrader-2；化合物 T18606PROTAC ER Degrader-2
PROTAC ER Degrader-2 serves as a synthesis intermediate for the production of PAC, a compound that incorporates the ADCs linker and PROTACs, which are subsequently conjugated to an antibody. PAC, exhibits a greater capability to degrade estrogen receptor-alpha (ERα) compared to PROTAC (without the presence of an antibody)[1].
价 格：￥电议型 号：T18606产 地：中国大陆
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T18605PROTAC ERα Degrader-2；化合物 T18605PROTAC ERα Degrader-2
PROTAC ERα Degrader-2 is composed of a cIAP1 ligand binding group, a linker, and an estrogen receptor α (ERα) binding group, serving as an ERα degrader. It achieves maximal ERα degradation in human mammary tumor MCF7 cells at a concentration of 30 μM. Degradation inducers that utilize cIAP1 are referred to as specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
价 格：￥电议型 号：T18605产 地：中国大陆
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T18231MAC glucuronide linker-2；化合物 T18231MAC glucuronide linker-2
MAC glucuronide linker-2 is an ADC linker employed in the synthesis of ADCs, offering cleavability [1].
价 格：￥电议型 号：T18231产 地：中国大陆
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T17728PROTAC CDK9 degrader-2；化合物 T17728PROTAC CDK9 degrader-2
PROTAC CDK9 degrader-2 (compounds 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 μM in MCF-7 cell lines. Natural product Wogonin binds ubiquitin E3 ligase cereblon (CRBN) via a linker to form PROTAC[1].
价 格：￥电议型 号：T17728产 地：中国大陆
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T17224VER-246608；化合物VER-246608VER-246608
VER-246608 is an effective and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (IC50s: 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively).VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin.
价 格：￥电议型 号：T17224产 地：中国大陆
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T17028Tefinostat；特诺司他CHR-2845；CHR-2845
Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1).Tefinostat exhibits antitumor activity and can be used in the study of leukemia and advanced hematologic malignancies.
价 格：￥电议型 号：T17028产 地：中国大陆
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T16841SAR-260301；化合物 T16841SAR-260301
SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).
价 格：￥电议型 号：T16841产 地：中国大陆
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T16796RPR-260243；化合物 T16796RPR-260243
RPR-260243 is a novel activator of HERG and modifies HERG currents inhibited by dofetilide (IC50 = 58 nM).
价 格：￥电议型 号：T16796产 地：中国大陆
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T16743Rhodamine 123；罗丹明123R-22420|||RH-123；R-22420|||罗丹明 123|||RH-123|||罗丹明123
Rhodamine 123 is a fluorescent dye (λex=503 nm, λem=527 nm).
价 格：￥电议型 号：T16743产 地：中国大陆
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T16708R-268712；化合物R-268712R-268712
R-268712 is a specific activin receptor-like kinase 5 (ALK5) inhibitor(IC50 of 2.5 nM). It is also an orally active transforming growth factor-β type I receptor inhibitor.
价 格：￥电议型 号：T16708产 地：中国大陆
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T16694Pyridoclax；化合物 T16694MR-29072；MR-29072
Pyridoclax is an inhibitor of potential Mcl-1.
价 格：￥电议型 号：T16694产 地：中国大陆
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T14927Centrinone；化合物CentrinoneLCR-263；LCR-263
Centrinone (LCR-263) (LCR-263) is a reversible inhibitor of polo-like kinase 4 (PLK4; Ki:0.16 nM).
价 格：￥电议型 号：T14927产 地：中国大陆
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T13846PROTAC RIPK degrader-2；化合物 T13846PROTAC RIPK degrader-2
PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.
价 格：￥电议型 号：T13846产 地：中国大陆
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T13837PROTAC CRABP-II Degrader-2；化合物 T13837PROTAC CRABP-II Degrader-2
PROTAC CRABP-II Degrader-2 is a potent degrader of cellular retinoic acid binding protein (CRABP-II) based on cIAp1.
价 格：￥电议型 号：T13837产 地：中国大陆
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T13834PROTAC BRD4 Degrader-2；化合物 T13834PROTAC BRD4 Degrader-2
PROTAC BRD4 Degrader-2 is an efficacious degrader of PROTAC BRD4(BRD4 BD1,IC50 of 14.2 nM).
价 格：￥电议型 号：T13834产 地：中国大陆
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T13666Dupilumab；达必妥REGN-668|||SAR-231893；REGN-668|||SAR-231893
Dupilumab (REGN-668) is a systemic immunomodulator for AD. Dupilumab is a fully human monoclonal antibody against the alpha subunit of the interleukin-4 receptor, which inhibits downstream signaling of IL-4 and IL-13 and has been shown to improve atopic dermatitis.
价 格：￥电议型 号：T13666产 地：中国大陆
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T13002SSR-241586；化合物 T13002SSR-241586
SSR-241586 is a neurokinin receptors antagonist,and is shown to be active in the treatment of depression, schizophrenia, urinary trouble, emesis, and irritable bowel syndrome (IBS).
价 格：￥电议型 号：T13002产 地：中国大陆
