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  • T62796VEGFR-2-IN-13；化合物 VEGFR-2-IN-13VEGFR-2-IN-13

    VEGFR-2-IN-13 (Compound 19a) is a potent VEGFR-2 inhibitor (IC50: 3.4 nM). vEGFR-2-IN-13 arrests the HepG2 cell cycle in G2/M phase and induces apoptosis.

    价 格：￥电议型 号：T62796产 地：中国大陆

  • T62763VEGFR-2-IN-12；化合物 VEGFR-2-IN-12VEGFR-2-IN-12

    VEGFR-2-IN-12 (compound 6g), a 2-oxoquinoxalinyl-1,2,4-triazole, is a potent inhibitor of VEGFR-2 (IC50: 0.037 μM). VEGFR-2-IN-12 has anti-tumour effects.

    价 格：￥电议型 号：T62763产 地：中国大陆

  • T62439VEGFR-2-IN-14；化合物 VEGFR-2-IN-14VEGFR-2-IN-14

    VEGFR-2-IN-14 (Compound 5) is a potent inhibitor of VEGFR-2, which inhibits the growth of HepG2 cells in the Pre-G1 phase and induces apoptosis.

    价 格：￥电议型 号：T62439产 地：中国大陆

  • T62431HIV-1 inhibitor-25；化合物 HIV-1 inhibitor-25HIV-1 inhibitor-25

    HIV-1 inhibitor-25 (compound R-12a) is a potent inhibitor of HIV-1 reverse transcription (HIV-1 RT) (IC50: 0.1061 nM). HIV-1 inhibitor-25 exhibits a high antiviral effect against wild-type HIV-1 with an EC50 value of 13.6 nM and a low cytotoxicity (to MT). HIV-1 inhibitor-25 also inhibits HIV-1 mutants (L100I, K103 N, Y181C, Y188L, E138K, F227L+V106A) with EC50=0.1961 ~ 5.8136 μM. inhibitor-25 can be used to study AIDS.

    价 格：￥电议型 号：T62431产 地：中国大陆

  • T62430HIV-1 inhibitor-24；化合物 HIV-1 inhibitor-24HIV-1 inhibitor-24

    HIV-1 inhibitor-24 (compound S-12a) is a potent inhibitor of HIV-1 reverse transcription (HIV-1 RT) (IC50: 9.5 nM). HIV-1 inhibitor-24 exhibits a high antiviral effect on wild-type HIV-1 with an EC50 value of 1.6 nM and low cytotoxicity (CC50 on MT-4 cells). HIV-1 inhibitor-24 was well tolerated in mice at a dose of 2 g/kg and had a significant cardiovascular safety profile.

    价 格：￥电议型 号：T62430产 地：中国大陆

  • T62352CXCR4 modulator-2；化合物 CXCR4 modulator-2CXCR4 modulator-2

    CXCR4 modulator-2 (compound Z7R) is a potent modulator of CXCR4 (IC50: 1.25 nM). CXCR4 modulator-2 exhibits good stability in mouse serum (t1/2= 77.1 min) and has anti-inflammatory effects in a mouse oedema model.

    价 格：￥电议型 号：T62352产 地：中国大陆

  • T62314VEGFR-2-IN-25；化合物 VEGFR-2-IN-25VEGFR-2-IN-25

    VEGFR-2-IN-25 (compound 5d) is a potent inhibitor of VEGFR-2 (IC50: 12.1 nM).

    价 格：￥电议型 号：T62314产 地：中国大陆

  • T62123FNDR-20123；化合物 FNDR-20123FNDR-20123

    FNDR-20123 is the first safe and effective anti-malarial HDAC inhibitor, acting on both Plasmodium falciparum HDAC (IC50: 31 nM) and human HDAC (IC50: 3 nM). FNDR-20123 inhibited HDAC1 (IC50: 25 nM), HDAC2 (IC50: 29 nM), HDAC3 (IC50: 2 nM), HDAC6 (IC50: 11 nM), HDAC8 (IC50: 282 nM) and, at nanomolar concentrations, HDAC3 (IC50: 2 nM). The inhibitor of HDAC subtype III was also observed at nanomolar concentrations.

    价 格：￥电议型 号：T62123产 地：中国大陆

  • T62079MEK4 inhibitor-2；化合物 MEK4 inhibitor-2MEK4 inhibitor-2

    MEK4 Inhibitor-2, a novel MEK4 inhibitor, demonstrates efficacy against pancreatic adenocarcinoma, exhibiting an IC50 value of 83 nM.

    价 格：￥电议型 号：T62079产 地：中国大陆

  • T62071VEGFR-2-IN-16；化合物 VEGFR-2-IN-16VEGFR-2-IN-16

    VEGFR-2-IN-16 (Compound 15b) is a potent inhibitor of VEGFR-2 (IC50: 86.36 nM) that exhibits antitumour effects.

    价 格：￥电议型 号：T62071产 地：中国大陆

  • T62010HIV-1 inhibitor-20；化合物 HIV-1 inhibitor-20HIV-1 inhibitor-20

    HIV-1 inhibitor-20 is a potent HIV-1 inhibitor.

    价 格：￥电议型 号：T62010产 地：中国大陆

  • T61894sEH inhibitor-2；化合物 sEH inhibitor-2sEH inhibitor-2

    SEH inhibitor-2 (compound 5l) is a soluble epoxide hydrolase (sEH) inhibitor with oral activity (IC50=0.9 nM), and the predicted oral absorption percentage is 71.2-88.4%. SEH inhibitor-2 can maintain a high concentration of eicosanoic acid (EETs) in serum. SEH inhibitor-2 has research value in cardiovascular protection.

    价 格：￥电议型 号：T61894产 地：中国大陆

  • T61861VEGFR-2-IN-20；化合物 VEGFR-2-IN-20VEGFR-2-IN-20

    VEGFR-2-IN-20 (Compound 7) is a highly effective VEGFR inhibitor with significant potential for cancer research [1].

    价 格：￥电议型 号：T61861产 地：中国大陆

  • T61688Nrf2 activator-2；化合物 Nrf2 activator-2Nrf2 activator-2

    Nrf2 activator-2 (referred to as compound O15), an Osthole derivative, is a highly potent Nrf2 agonist exhibiting an EC 50 of 2.9 μM in 293 T cells. By effectively disrupting the binding between Keap1 and Nrf2, Nrf2 activator-2 activates the Nrf2 pathway. Furthermore, this compound significantly reduces the ubiquitination of Nrf2 in cells, indicating its potential in regulating Nrf2 activity [1].

    价 格：￥电议型 号：T61688产 地：中国大陆

  • T61631VEGFR-2-IN-23；化合物 VEGFR-2-IN-23VEGFR-2-IN-23

    VEGFR-2-IN-23 (compound 11b) is a highly potent and selective inhibitor of VEGFR-2, with an impressive IC 50 value of 0.34 nM. This compound exhibits notable antitumor activity, capable of inducing apoptosis and cell cycle arrest specifically at the G1 phase [1].

    价 格：￥电议型 号：T61631产 地：中国大陆

  • T61572FNDR-20123 free base；化合物 FNDR-20123 free baseFNDR-20123 free base

    FNDR-20123 free base, a pioneering and orally administered anti-malarial agent, acts as a Histone Deacetylase (HDAC) inhibitor, displaying potent efficacy with IC50 values of 31 nM for Plasmodium and 3 nM for human HDAC, respectively. It effectively targets both the asexual (IC50=41 nM) and sexual blood stages (IC50=190 nM for male gametocytes) of Plasmodium falciparum. Additionally, FNDR-20123 free base inhibits multiple HDAC isoforms, namely HDAC1, HDAC2, HDAC3, HDAC6, and HDAC8, with respecti

    价 格：￥电议型 号：T61572产 地：中国大陆

  • T61561VEGFR-2-IN-18；化合物 VEGFR-2-IN-18VEGFR-2-IN-18

    VEGFR-2-IN-18 (Compound 15d) is a high-potency inhibitor of VEGFR-2, with an IC 50 value of 60 nM. This compound effectively initiates cell apoptosis and demonstrates significant antitumor properties [1].

    价 格：￥电议型 号：T61561产 地：中国大陆

  • T61542VEGFR-2-IN-17；化合物 VEGFR-2-IN-17VEGFR-2-IN-17

    VEGFR-2-IN-17 (Compound 15a) is a highly potent inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2), with an IC50 value of 67.25 nM. This compound exhibits significant antitumor properties [1].

    价 格：￥电议型 号：T61542产 地：中国大陆

  • T61489VEGFR-2/DHFR-IN-1；化合物 VEGFR-2/DHFR-IN-1VEGFR-2/DHFR-IN-1

    VEGFR-2/DHFR-IN-1 (compound 8b) is a chemical inhibitor targeting VEGFR-2 and DHFR, exhibiting IC50 values of 0.384 μM and 7.881 μM, respectively. It demonstrates effective antibacterial properties against a range of pathogens including Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA, and MRSA, with MIC values ranging from 8 to 16 μg/mL. Additionally, this compound shows potent cytotoxic effects against various cancer cell lines such as C26, HepG2, and MCF7, with IC50 values

    价 格：￥电议型 号：T61489产 地：中国大陆

  • T61318BRD4 Inhibitor-20；BRD4抑制剂20BRD4 Inhibitor-20

    BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity. BRD4 Inhibitor-20 has antiproliferative activity in cancer cell lines and is used in studies of various cancers, such as colon cancer.

    价 格：￥电议型 号：T61318产 地：中国大陆

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