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T752295’-O-DMTr-2’-O-MOE inosine 3’-P-methyl phosphonamidite；化合物 5’-O-DMTr-2’-O-MOE inosine 3’-P-methyl ph
5’-O-DMTr-2’-O-MOE inosine 3’-P-methyl phosphonamidite, a purine nucleoside analog, exhibits extensive antitumor activity specific to indolent lymphoid malignancies. Its anticancer effects stem from the inhibition of DNA synthesis and the induction of apoptosis, among other mechanisms [1].
价 格：￥电议型 号：T75229产 地：中国大陆
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T751905’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite；化合物 5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl ph
5’-O-DMTr-2’,2’-difluoro-dC(Bz)-methyl phosphonamidite is a purine nucleoside analog with extensive antitumor activity against indolent lymphoid malignancies. Its anticancer efficacy stems from the inhibition of DNA synthesis and the induction of apoptosis, among other mechanisms [1].
价 格：￥电议型 号：T75190产 地：中国大陆
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T7513Protease-Activated Receptor-2, amide；蛋白酶活化的受体-2，酰胺SLIGKV-NH2；蛋白酶活化的受体-2，酰胺|||SLIGKV-NH2|||H-丝氨酰亮氨酰异亮
Protease-Activated Receptor-2, amide (SLIGKV-NH2) is an agonist of PAR2 (IC50 : 10.4 M)
价 格：￥电议型 号：T7513产 地：中国大陆
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T75099PROTAC STAT3 degrader-2；化合物 PROTAC STAT3 degrader-2PROTAC STAT3 degrader-2
PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC 50 of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research [1] .
价 格：￥电议型 号：T75099产 地：中国大陆
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T75023Nampt degrader-2；化合物 Nampt degrader-2Nampt degrader-2
Nampt degrader-2, a fluorescent PROTAC, exhibits efficient degradation of NAMPT at an IC50 of 41.9 nM. It operates by binding to both NAMPT and VHL, initiating the formation of a ternary complex that triggers NAMPT degradation through the ubiquitin-proteasome system (UPS). This activity significantly lowers NAD+ levels and displays potent antitumor effects [1].
价 格：￥电议型 号：T75023产 地：中国大陆
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T74742TRPV1 activator-2；化合物 TRPV1 activator-2TRPV1 activator-2
TRPV1 activator-2 (Compound 9), a capsaicin head analog, engages in targeted interactions with channel residues at the lipid-water interface [1].
价 格：￥电议型 号：T74742产 地：中国大陆
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T74518PROTAC VEGFR-2 degrader-2；化合物 PROTAC VEGFR-2 degrader-2PROTAC VEGFR-2 degrader-2
PROTAC VEGFR-2 degrader-2 (PROTAC-4), a specific degrader of VEGFR-2, demonstrates minimal inhibition of VEGFR-2 (IC50 > 1 μM) and low anti-proliferative activity towards EA.hy926 cells (IC50 > 100 μM) [1].
价 格：￥电议型 号：T74518产 地：中国大陆
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T74517PROTAC VEGFR-2 degrader-1；化合物 PROTAC VEGFR-2 degrader-1PROTAC VEGFR-2 degrader-1
PROTAC VEGFR-2 Degrader-1 (PROTAC-1), a specific degrader of PROTAC VEGFR-2, demonstrates minimal inhibition of VEGFR-2 (IC50 > 1 μM) and exhibits low anti-proliferative effects on EA.hy926 cells (IC50 > 100 μM) [1].
价 格：￥电议型 号：T74517产 地：中国大陆
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T74430SHP2 protein degrader-2；化合物 SHP2 protein degrader-2SHP2 protein degrader-2
SHP2 protein degrader-2 (SHP2-D26), a PROTAC degrader targeting the SHP2 protein, effectively diminishes its expression levels across various cancer cell types [1].
价 格：￥电议型 号：T74430产 地：中国大陆
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T74397nAChR modulator-2；化合物 nAChR modulator-2nAChR modulator-2
nAChR modulator-2, a insecticide, is a insect nAChR orthosteric modulator [1] .
价 格：￥电议型 号：T74397产 地：中国大陆
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T74356PROTAC SOS1 degrader-2；化合物 PROTAC SOS1 degrader-2PROTAC SOS1 degrader-2
PROTAC SOS1 degrader-2, a potent degrader of PROTAC SOS1, effectively reduces the expression of pERK and RAS-GTP in a dose-dependent manner. It significantly inhibits tumor growth in vivo [1].
价 格：￥电议型 号：T74356产 地：中国大陆
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T74138PROTAC Bcl-xL degrader-2；化合物 PROTAC Bcl-xL degrader-2PROTAC Bcl-xL degrader-2
PROTAC Bcl-xL degrader-2, based on von Hippel-Lindau ligand, is a potent degrader of Bcl-xL (a Bcl-2 family member), demonstrating an IC 50 of 0.6 nM.
价 格：￥电议型 号：T74138产 地：中国大陆
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T74062PROTAC IRAK4 degrader-2；化合物 PROTAC IRAK4 degrader-2PROTAC IRAK4 degrader-2
PROTAC IRAK4 Degrader-2 (Compound 9) is a PROTAC-based degrader that potently reduces IRAK4 levels, achieving a DC50 of 151 nM in peripheral blood mononuclear cells (PBMCs). It also notably decreases IRAK4 protein levels with a DC50 of 36 nM in the same cell type and inhibits several cytokines in PBMCs [1].
价 格：￥电议型 号：T74062产 地：中国大陆
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T73868PROTAC BTK Degrader-2；化合物 PROTAC BTK Degrader-2PROTAC BTK Degrader-2
PROTAC BTK Degrader-2, a potent degrader of BTK through the PROTAC mechanism, effectively diminishes BTK protein levels [1].
价 格：￥电议型 号：T73868产 地：中国大陆
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T73395ASPER-29；化合物 ASPER-29ASPER-29
ASPER-29, an analog of Asperphenamate, acts as a dual inhibitor of cathepsin L and S, displaying inhibitory concentrations (IC50) of 6.03 μM and 5.02 μM, respectively. This compound is utilized in the study of cancer migration and invasion.
价 格：￥电议型 号：T73395产 地：中国大陆
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T72890VEGFR-2-IN-30；化合物 VEGFR-2-IN-30VEGFR-2-IN-30
VEGFR-2-IN-30, a compound acting primarily as a VEGFR-2 inhibitor (IC50: 66 nM), demonstrates additional inhibitory effects on PDGFR, EGFR, and FGFR1, with IC50 values of 180, 98, and 82 nM, respectively. It effectively arrests cancer cells in the S-phase and induces both early and late apoptosis.
价 格：￥电议型 号：T72890产 地：中国大陆
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T72636BRD4 Inhibitor-26；化合物 BRD4 Inhibitor-26BRD4 Inhibitor-26
BRD4 Inhibitor-26, a bromodomain protein 4 (BRD4) inhibitor/nitric oxide-donator, exhibits inhibitory activity against BRD4 (BD1) and BRD4 (BD2) with IC50 values of 0.82 μM and 1.94 μM, respectively. It is utilized in ovarian cancer research.
价 格：￥电议型 号：T72636产 地：中国大陆
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T72630BRD4 Inhibitor-25；化合物 BRD4 Inhibitor-25BRD4 Inhibitor-25
BRD4 Inhibitor-25, a chemical compound targeting the BD1 and BD2 domains of BRD4 with half-maximal inhibitory concentrations (IC50s) of 0.82 μM and 1.94 μM respectively, demonstrates efficacy in inducing apoptotic and autophagic cell death in ovarian cancer cells. This compound is utilized in researching cancers, cardiovascular, neuromuscular, and inflammatory disorders.
价 格：￥电议型 号：T72630产 地：中国大陆
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T72617Nampt activator-2；Nampt激活剂2Nampt activator-2
Nampt activator-2 is a NAMPT activator (EC50: 0.023 μM). Nampt activator-2 has an affinity for CYP2C9, 2D6, and 2C19 with affinity values of 0.060 μM, 0.41 μM, and 0.59 μM, respectively.Nampt activator-2 can be used in the study of atherosclerosis, obesity, type II diabetes, insulin resistance, and type I diabetes.
价 格：￥电议型 号：T72617产 地：中国大陆
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T72608VEGFR-2/BRAF-IN-2；化合物 VEGFR-2/BRAF-IN-2VEGFR-2/BRAF-IN-2
VEGFR-2/BRAF-IN-2, as a dual VEGFR-2 and BRAF kinase inhibitor, exhibits potent IC50 values of 0.111 ?M, 0.089 ?M, and 0.071 ?M against VEGFR-2, BRAF V600E, and BRAF WT, respectively. This compound effectively induces apoptosis and predominantly arrests the cell cycle in the G1 phase.
价 格：￥电议型 号：T72608产 地：中国大陆
