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T18611AP1867-2-(carboxymethoxy)；化合物 T18611PROTAC FKBP12-binding moiety 2；PROTAC FKBP12-binding moiety 2
AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG molecules[1].
价 格：￥电议型 号：T18611产 地：中国大陆
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T17611Bis-PEG-TFP ester (MW 5000)；化合物 T17611Bis-PEG-TFP ester (MW 5000)
Bis-PEG-TFP ester (MW 5000) is a polyethylene glycol (PEG) based linker compound utilized for synthesizing Proteolysis Targeting Chimeras (PROTACs)[1].
价 格：￥电议型 号：T17611产 地：中国大陆
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T17287ZD-1611；化合物 T17287ZD-1611
ZD-1611 is an effective and selective ETA receptor antagonist. It is used for the research of ischemic stroke.
价 格：￥电议型 号：T17287产 地：中国大陆
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T17045Teslexivir；化合物 T17045BTA074|||AP 611074；BTA074|||AP 611074
Teslexivir is a topical antiviral agent that is an effective and selective inhibitor of the interaction between two essential viral proteins, E1 and E2.
价 格：￥电议型 号：T17045产 地：中国大陆
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T16119MLT-747；化合物 T16119MLT-747
MLT-747 is an effective and allosteric inhibitor of MALT1. It binds MALT1 in the allosteric Trp580 pocket (IC50: 14 nM).
价 格：￥电议型 号：T16119产 地：中国大陆
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T16118MLS0315771；化合物MLS0315771MLS0315771
MLS0315771 is an effective and biologically active competitive phosphomannose isomerase (MPI) inhibitor (IC50: ~1 μM and a Ki: 1.4 μM).
价 格：￥电议型 号：T16118产 地：中国大陆
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T16117Pevonedistat hydrochloride化合物 T16117MLN4924 hydrochloride
Pevonedistat hydrochloride is an effective and selective inhibitor of NEDD8-activating enzyme (IC50: 4.7 nM).
价 格：￥电议型 号：T16117产 地：中国大陆
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T16116MLN-4760；化合物MLN-4760MLN-4760
MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).
价 格：￥电议型 号：T16116产 地：中国大陆
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T16115MLi-2；化合物MLi-2MLi-2
MLi-2 is a structurally novel, highly potent, and selective LRRK2 kinase inhibitor with central nervous system activity. MLi-2 exhibits exceptional potency in a purified LRRK2 kinase assay in vitro (IC50 = 0.76 nM), a cellular assay monitoring dephosphorylation of LRRK2 pSer935 LRRK2 (IC50 = 1.4 nM), and a radioligand competition binding assay (IC50 = 3.4 nM).
价 格：￥电议型 号：T16115产 地：中国大陆
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T16114Pavinetant；化合物 PavinetantMLE-4901|||AZD4901|||AZD2624；MLE-4901|||AZD4901|||AZD2624
Pavinetant (MLE-4901) is an orally available neurokinin-3 receptor (NK3R) antagonist used to improve menopausal symptoms.
价 格：￥电议型 号：T16114产 地：中国大陆
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T16113ML753286；化合物 T16113ML753286
ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (IC50: 0.6 μM). It is also stable in plasma across species.
价 格：￥电议型 号：T16113产 地：中国大陆
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T16112ML67-33化合物 T16112ML-67-33|||ML6733|||ML67 33
ML67-33 rapidly and reversibly affects K2P2.1 (TREK-1) (EC50s: 36.3 μM and 9.7 μM in cell-free and HEK293 cells, respectively). ML67-33 is a selective activator of temperature- and mechano-sensitive K2P channels.
价 格：￥电议型 号：T16112产 地：中国大陆
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T16110ML418；化合物ML418ML418
ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.
价 格：￥电议型 号：T16110产 地：中国大陆
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T1611Isotretinoin；异维A酸13-cis-Retinoic acid；13-cis-Retinoic acid|||异维A酸
Isotretinoin (13-cis-Retinoic acid) binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. Isotretinoin is a naturally-occurring retinoic acid with potential antineoplastic activity. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization.
价 格：￥电议型 号：T1611产 地：中国大陆
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T15611JH-RE-06；化合物JH-RE-06JH-RE-06
JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing the recruitment of mutagenic POLζ. JH-RE-06 is an effective REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), which targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 also improves chemotherapy.
价 格：￥电议型 号：T15611产 地：中国大陆
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T15375Inavolisib；化合物 InavolisibGDC-0077|||RG6114；GDC-0077|||RG6114
Inavolisib (GDC-0077) is an orally available and selective inhibitor of PI3Kα (IC50=0.038 nM). Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3.
价 格：￥电议型 号：T15375产 地：中国大陆
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T14611Biotin-PEG8-alcohol；化合物 T14611Biotin-PEG8-alcohol
Biotin-PEG8-alcohol is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T14611产 地：中国大陆
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T131611Kaempferitrin (Lespidin; Kaempferol 3,7-dirhamnoside)；化合物 Kaempferitrin (Lespidin; Kaempferol 3,7-di
Kaempferitrin (Lespidin; Kaempferol 3,7-dirhamnoside) is a useful organic compound for research related to life sciences and the catalog number is T131611.
价 格：￥电议型 号：T131611产 地：中国大陆
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T12820S16961；化合物S16961S169611；S169611
S16961 (S169611) is an agonist of nicotinic receptor.
价 格：￥电议型 号：T12820产 地：中国大陆
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T12611LRevizinone；化合物 T12611LR80122；R80122
Revizinone is a novel selective phosphodiesterase inhibitor with IC50 values on this enzyme to 0.036 microM.
价 格：￥电议型 号：T12611L产 地：中国大陆
