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  • T82420FAK-IN-12；化合物 FAK-IN-12FAK-IN-12

    FAK-IN-12 (Compound 12S) is a selective FAK inhibitor with an IC50 of 47 nM. It effectively suppresses proliferation of MGC-803, HCT-116, and KYSE30 cells with IC50 values of 0.24, 0.45, and 0.44 μM, respectively. Additionally, FAK-IN-12 promotes apoptosis and cellular senescence [1].

    价 格：￥电议型 号：T82420产 地：中国大陆

  • T82393FLT3/CHK1-IN-1；化合物 FLT3/CHK1-IN-1FLT3/CHK1-IN-1

    Compound 18, also known as FLT3/CHK-IN-1, is a dual inhibitor targeting FLT3 and CHK1, exhibiting over 1700-fold selectivity towards c-KIT and significantly diminishing hERG affinity, with an IC50 of 58.4 μM. It demonstrates efficacy in suppressing tumor growth in mouse xenotransplantation models implanted with MV-4-11 cells [1].

    价 格：￥电议型 号：T82393产 地：中国大陆

  • T82368FTO-IN-10；化合物 FTO-IN-10FTO-IN-10

    FTO-IN-10 (compound 7), a potent inhibitor of the human demethylase FTO (fat mass and obesity-associated protein), exhibits an IC50 of 4.5 μM. It interacts with the binding pocket of FTO´s structural domain II via hydrophobic and hydrogen bonding interactions, and promotes DNA damage and autophagic cell death in A549 cells [1].

    价 格：￥电议型 号：T82368产 地：中国大陆

  • T82361FXIIa-IN-1；化合物 FXIIa-IN-1FXIIa-IN-1

    XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor with an apparent inhibition constant (K i app) of 97.8 nM, utilized in the study of thrombosis [1].

    价 格：￥电议型 号：T82361产 地：中国大陆

  • T82356GABA-IN-1；化合物 GABA-IN-1GABA-IN-1

    GABA-IN-1 (Compound 6), a GABA inhibitor, exhibits larvicidal and insecticidal properties, achieving a mortality rate of 93% at a concentration of 50 mg/L [1].

    价 格：￥电议型 号：T82356产 地：中国大陆

  • T82343Gamma-Glutamyl Transferase-IN-1；化合物 Gamma-Glutamyl Transferase-IN-1Gamma-Glutamyl Transferase-IN-1

    Gamma-Glutamyl Transferase-IN-1 (compound 4de), a β-carboline 1-hydrazide inhibitor, exhibits antifungal and antibacterial properties by targeting glutamyltransferase. Its mechanism of action involves inducing the accumulation of reactive oxygen species, disrupting cell membranes, and dysregulating histone acetylation [1].

    价 格：￥电议型 号：T82343产 地：中国大陆

  • T82329GDI2-IN-1；化合物 GDI2-IN-1GDI2-IN-1

    GDI2-IN-1 (compound (+)-37), a GDP-dissociation inhibitor beta (GDI2) inhibitor, demonstrates potent inhibitory activity with an IC50 of 2.87 μM and a K D of 36 μM, and exhibits excellent in vivo antitumor efficacy in pancreatic xenograft models overexpressing GDI2 [1].

    价 格：￥电议型 号：T82329产 地：中国大陆

  • T82289Glycolate oxidase-IN-1；化合物 Glycolate oxidase-IN-1Glycolate oxidase-IN-1

    Glycolate oxidase-IN-1 (compound 26), a salicylic acid derivative, serves as an inhibitor of glycolate oxidase (GO) and exhibits an inhibitory concentration (IC50) of 38.2 μM. It is efficacious in reducing oxalate production in hyperoxaluric hepatocytes and has potential applications in researching primary hyperoxaluria type 1 (PH1) [1].

    价 格：￥电议型 号：T82289产 地：中国大陆

  • T82267GPAT-IN-1；化合物 GPAT-IN-1GPAT-IN-1

    GPAT-IN-1, a glycerol-3-phosphate acyltransferase (GPAT) inhibitor, exhibits an inhibitory concentration (IC50) of 8.9 μM and is utilized in obesity research [1].

    价 格：￥电议型 号：T82267产 地：中国大陆

  • T82235hCA/Wnt/β-catenin-IN-1；化合物 hCA/Wnt/β-catenin-IN-1hCA/Wnt/β-catenin-IN-1

    hCA/Wnt/β-catenin-IN-1 (Compd 15) serves as an inhibitor with selective affinity for hCA isoforms II, IX, and XII, exhibiting K i values of 33.6, 24.1, and 6.8 nM, respectively. Additionally, this compound attenuates P-gp activity and impedes the Wnt/β-catenin signaling pathway. Furthermore, it compromises the viability of cancer cells, specifically targeting the NCI/ADR-RES DOX-resistant cell line [1].

    价 格：￥电议型 号：T82235产 地：中国大陆

  • T82234hCAIX-IN-19；化合物 hCAIX-IN-19hCAIX-IN-19

    hCAIX-IN-19 is a sulfonamide inhibitor with an inhibition constant (KI) of 6.2 nM for hCAIX, exhibiting significant selectivity towards hCAIX over hCAI (hCA I/hCAIX = 117).

    价 格：￥电议型 号：T82234产 地：中国大陆

  • T82232hCES2A-IN-1；化合物 hCES2A-IN-1hCES2A-IN-1

    hCES2A-IN-1 (compound 20w), a potent hCES2A inhibitor derived from bysspectin A, exhibits an IC50 value of 1.6 nM, demonstrating an approximately 1000-fold potency enhancement compared to its lead compound, bysspectin A [1].

    价 格：￥电议型 号：T82232产 地：中国大陆

  • T82231hCES2-IN-1；化合物 hCES2-IN-1hCES2-IN-1

    hCES2-IN-1 (Compound 24) is a reversible, selective inhibitor of the human carboxylesterase 2 (hCES2) enzyme, exhibiting an IC50 of 6.72 μM. This compound diminishes hCES2 levels in vivo and demonstrates efficacy in alleviating irinotecan-induced delayed diarrhea and DSS-induced ulcerative colitis [1].

    价 格：￥电议型 号：T82231产 地：中国大陆

  • T82230HCoV-OC43-IN-1；化合物 HCoV-OC43-IN-1HCoV-OC43-IN-1

    HCoV-OC43-IN-1 (Compound IV-16) serves as an inhibitor of the coronavirus HCoV-OC43, exhibiting antiviral efficacy with an EC50 of 90 nM. It effectively inhibits the mRNA levels and expression of the viral nucleocapsid protein (NP) [1].

    价 格：￥电议型 号：T82230产 地：中国大陆

  • T82227HDAC1/CDK7-IN-1；化合物 HDAC1/CDK7-IN-1HDAC1/CDK7-IN-1

    HDAC1/CDK7-IN-1 (compound 8e) serves as a dual inhibitor targeting both CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM , respectively. This compound effectively suppresses the proliferation of various cancer cell lines, including MDA-MB-231, MCF-7, A549, and HCT-116. Additionally, it triggers cell cycle arrest and apoptosis in HCT-116 cells and impedes their migration [1].

    价 格：￥电议型 号：T82227产 地：中国大陆

  • T82223hDHODH-IN-13；化合物 hDHODH-IN-13hDHODH-IN-13

    hDHODH-IN-13 (compound w2), an inhibitor of human dihydroorotate dehydrogenase (hDHODH), exhibits an IC50 of 173.4 nM and has potential research applications in studying inflammatory bowel disease (IBD) [1].

    价 格：￥电议型 号：T82223产 地：中国大陆

  • T8218Vanin-1-IN-1；化合物Vanin-1-IN-1VUN34002；VUN34002

    Vanin-1-IN-1 (VUN34002) is an vanin-1 enzyme inhibitor.

    价 格：￥电议型 号：T8218产 地：中国大陆

  • T82168HSP70/SIRT2-IN-1；化合物 HSP70/SIRT2-IN-1HSP70/SIRT2-IN-1

    HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2. This compound possesses antitumor activity [1].

    价 格：￥电议型 号：T82168产 地：中国大陆

  • T82150Hyaluronan-IN-1；化合物 Hyaluronan-IN-1Hyaluronan-IN-1

    Hyaluronan-IN-1, a biological active peptide comprising 12 amino acids, functions as an inhibitor of hyaluronan (HA), a high molecular weight glycosaminoglycan prevalent in the extracellular matrix and on cell surfaces. It demonstrates specific binding to various forms of HA, including soluble, immobilized, and cell-associated, and nearly completely inhibits leukocyte adhesion to HA substrates.

    价 格：￥电议型 号：T82150产 地：中国大陆

  • T82136ICMT-IN-1；化合物 ICMT-IN-1ICMT-IN-1

    ICMT-IN-1 (compound 75) is a potent ICMT inhibitor with an IC50 value of 0.0013 μM. This compound promotes dose-dependent cytoplasmic accumulation of ICMT in HCT-116 cells and effectively inhibits the proliferation of various cancer cell lines that express K-Ras and N-Ras [1].

    价 格：￥电议型 号：T82136产 地：中国大陆

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