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  • T82232hCES2A-IN-1；化合物 hCES2A-IN-1hCES2A-IN-1

    hCES2A-IN-1 (compound 20w), a potent hCES2A inhibitor derived from bysspectin A, exhibits an IC50 value of 1.6 nM, demonstrating an approximately 1000-fold potency enhancement compared to its lead compound, bysspectin A [1].

    价 格：￥电议型 号：T82232产 地：中国大陆

  • T82231hCES2-IN-1；化合物 hCES2-IN-1hCES2-IN-1

    hCES2-IN-1 (Compound 24) is a reversible, selective inhibitor of the human carboxylesterase 2 (hCES2) enzyme, exhibiting an IC50 of 6.72 μM. This compound diminishes hCES2 levels in vivo and demonstrates efficacy in alleviating irinotecan-induced delayed diarrhea and DSS-induced ulcerative colitis [1].

    价 格：￥电议型 号：T82231产 地：中国大陆

  • T82230HCoV-OC43-IN-1；化合物 HCoV-OC43-IN-1HCoV-OC43-IN-1

    HCoV-OC43-IN-1 (Compound IV-16) serves as an inhibitor of the coronavirus HCoV-OC43, exhibiting antiviral efficacy with an EC50 of 90 nM. It effectively inhibits the mRNA levels and expression of the viral nucleocapsid protein (NP) [1].

    价 格：￥电议型 号：T82230产 地：中国大陆

  • T82227HDAC1/CDK7-IN-1；化合物 HDAC1/CDK7-IN-1HDAC1/CDK7-IN-1

    HDAC1/CDK7-IN-1 (compound 8e) serves as a dual inhibitor targeting both CDK7 and HDAC1, with IC50 values of 893 nM and 248 nM , respectively. This compound effectively suppresses the proliferation of various cancer cell lines, including MDA-MB-231, MCF-7, A549, and HCT-116. Additionally, it triggers cell cycle arrest and apoptosis in HCT-116 cells and impedes their migration [1].

    价 格：￥电议型 号：T82227产 地：中国大陆

  • T82189HMGB1-IN-2；化合物 HMGB1-IN-2HMGB1-IN-2

    HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At a concentration of 30 μM, HMGB1-IN-2 reduces IL-1β, TNF-α, and caspase-1 p20 levels, and inhibits NF-κB p65 phosphorylation, providing anti-apoptotic effects. In vivo, HMGB1-IN-2 at a dose of 15 mg/kg administered intraperitoneally alleviates kidney injury in a mouse model of septic acute kidney injury. Furthermore, it inh

    价 格：￥电议型 号：T82189产 地：中国大陆

  • T82188HN-1；化合物 HN-1HN-1

    HN-1, a 12-mer peptide with specificity for head and neck squamous cell carcinoma (HNSCC), penetrates tumor tissue and facilitates the translocation of agents across cell membranes [1].

    价 格：￥电议型 号：T82188产 地：中国大陆

  • T8218Vanin-1-IN-1；化合物Vanin-1-IN-1VUN34002；VUN34002

    Vanin-1-IN-1 (VUN34002) is an vanin-1 enzyme inhibitor.

    价 格：￥电议型 号：T8218产 地：中国大陆

  • T82168HSP70/SIRT2-IN-1；化合物 HSP70/SIRT2-IN-1HSP70/SIRT2-IN-1

    HSP70/SIRT2-IN-1 (Compound 2a) serves as a dual inhibitor targeting both SIRT2 and HSP70, exhibiting an IC50 of 17.3±2.0 μM against SIRT2. This compound possesses antitumor activity [1].

    价 格：￥电议型 号：T82168产 地：中国大陆

  • T82167HSP70/SIRT2-IN-2；化合物 HSP70/SIRT2-IN-2HSP70/SIRT2-IN-2

    HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].

    价 格：￥电议型 号：T82167产 地：中国大陆

  • T82150Hyaluronan-IN-1；化合物 Hyaluronan-IN-1Hyaluronan-IN-1

    Hyaluronan-IN-1, a biological active peptide comprising 12 amino acids, functions as an inhibitor of hyaluronan (HA), a high molecular weight glycosaminoglycan prevalent in the extracellular matrix and on cell surfaces. It demonstrates specific binding to various forms of HA, including soluble, immobilized, and cell-associated, and nearly completely inhibits leukocyte adhesion to HA substrates.

    价 格：￥电议型 号：T82150产 地：中国大陆

  • T82136ICMT-IN-1；化合物 ICMT-IN-1ICMT-IN-1

    ICMT-IN-1 (compound 75) is a potent ICMT inhibitor with an IC50 value of 0.0013 μM. This compound promotes dose-dependent cytoplasmic accumulation of ICMT in HCT-116 cells and effectively inhibits the proliferation of various cancer cell lines that express K-Ras and N-Ras [1].

    价 格：￥电议型 号：T82136产 地：中国大陆

  • T82125ICMT-IN-2；化合物 ICMT-IN-2ICMT-IN-2

    ICMT-IN-2 (compound 45) serves as an ICMT inhibitor with an IC50 value of 0.168 μM [1].

    价 格：￥电议型 号：T82125产 地：中国大陆

  • T82074Immune cell migration-IN-1；化合物 Immune cell migration-IN-1Immune cell migration-IN-1

    Immune cell migration-IN-1 (compound 2) serves as a potent inhibitor of immune cell migration, with potential research applications for mitigating conditions such as dry eye diseases, eczema dermatitis, and psoriasis [1].

    价 格：￥电议型 号：T82074产 地：中国大陆

  • T82073Immune cell migration-IN-2；化合物 Immune cell migration-IN-2Immune cell migration-IN-2

    Immune cell migration-IN-2 is a potent inhibitor of immune cell migration, exhibiting an EC50 value of 13.5 nM in a T-cell adhesion assay. This compound is utilized in research pertaining to dry-eye and other retinal diseases [1]. As a click chemistry reagent, Immune cell migration-IN-2 possesses an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules.

    价 格：￥电议型 号：T82073产 地：中国大陆

  • T81964Laccase-IN-2；化合物 Laccase-IN-2Laccase-IN-2

    Laccase-IN-2 is a potent laccase inhibitor demonstrating excellent antifungal activity against Magnaporthe oryzae both in vitro and in vivo [1].

    价 格：￥电议型 号：T81964产 地：中国大陆

  • T81953LANA-DNA-IN-2；化合物 LANA-DNA-IN-2LANA-DNA-IN-2

    Compound 20, also known as LANA-DNA-IN-2, is an inhibitor of the interaction between latency-associated nuclear antigen (LANA) and DNA. It is employed in the study of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection [1].

    价 格：￥电议型 号：T81953产 地：中国大陆

  • T81932LIN28-IN-1；化合物 LIN28-IN-1LIN28-IN-1

    LIN28-IN-1 (compound 5) is a selective inhibitor targeting the RNA-binding protein LIN28, specifically binding to its cold shock domain (CSD). This compound robustly interrupts the LIN28-let-7 miRNA interaction with an IC 50 of 5.4 μM, thereby mitigating LIN28´s adverse effects on epigenetic gene control. Furthermore, LIN28-IN-1 exhibits significant anti-proliferative activity against LIN28-expressing JAR cancer cells, evidenced by an IC 50 value of 6.4 μM [1].

    价 格：￥电议型 号：T81932产 地：中国大陆

  • T81921LMP7-IN-2；化合物 LMP7-IN-2LMP7-IN-2

    LMP7-IN-2 is an inhibitor of LMP7 and may be utilized in the treatment of associated inflammatory diseases and disorders [1].

    价 格：￥电议型 号：T81921产 地：中国大陆

  • T81911LtaS-IN-2；化合物 LtaS-IN-2LtaS-IN-2

    LtaS-IN-2 (compound 13), a derivative of LtaS-IN-1 [1], is an LTA synthesis inhibitor with antibacterial properties against S. aureus and S. epidermidis, exhibiting MIC90 values of 0.5 μg/mL and 1 μg/mL, respectively.

    价 格：￥电议型 号：T81911产 地：中国大陆

  • T81851MASTL-IN-1；化合物 MASTL-IN-1MASTL-IN-1

    MASTL-IN-1 is a potent inhibitor of microtubule-associated serine/threonine kinase-like (MASTL), which plays a role in cell proliferation, migration, and invasion, thereby holding promise in cancer research [1].

    价 格：￥电议型 号：T81851产 地：中国大陆

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