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T81311RASP-IN-1；化合物 RASP-IN-1RASP-IN-1
RASP-IN-1 (Compound A), a lipophilic compound, serves as an inhibitor for macular degeneration and exhibits biological activity within the rabbit retina. In a mouse model [1], the administration of 14 C-RASP-IN-1 (10 mg/kg) intraperitoneally yielded a maximum concentration (C max) of 14.36 μg/g in the posterior eye cup 30 minutes post-treatment.
价 格：￥电议型 号：T81311产 地：中国大陆
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T81295Retrocyclin-1；化合物 Retrocyclin-1Retrocyclin-1
Retrocyclin-1, a Theta-defensin, selectively binds to carbohydrate-rich surface molecules such as fetuin, gp120 (K d =35.4 nM), CD4 (K d =31 nM), and galactosylceramide (K d =24.1 nM) [1], thereby shielding cells from HIV-1 infection.
价 格：￥电议型 号：T81295产 地：中国大陆
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T81293Retrocyclin-2；化合物 Retrocyclin-2Retrocyclin-2
Retrocyclin-2 is an antimicrobial peptide effective against human immunodeficiency virus (HIV), influenza A, and herpes simplex virus (HSV) [1].
价 格：￥电议型 号：T81293产 地：中国大陆
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T81272RIOK2-IN-1；化合物 RIOK2-IN-1RIOK2-IN-1
RIOK2-IN-1 (com 4) is a selective RIOK2 inhibitor with a Kd of 150 nM, though it demonstrates low cellular activity with an IC50 of 14,600 nM. As an atypical kinase, RIOK2´s involvement in ribosome maturation and cell cycle progression associates it with various human cancers. The derivative compound CQ211, an enhanced version of RIOK2-IN-1, exhibits robust in vivo and in vitro efficacy. It effectively inhibits the proliferation of MKN-1 and HT-29 cancer cell lines and hinders tumor growth
价 格：￥电议型 号：T81272产 地：中国大陆
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T81271RIOK2-IN-2；化合物 RIOK2-IN-2RIOK2-IN-2
RIOK2-IN-2 (8) functions as an inhibitor of RIOK2, exhibiting IC50 values of 3.02 μM in MKN-1 cells and 5.34 μM in MOLT4 cells [1].
价 格：￥电议型 号：T81271产 地：中国大陆
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T81254RPE65-IN-1；化合物 RPE65-IN-1RPE65-IN-1
RPE65-IN-1 (Compound 16e) serves as a potent inhibitor of RPE65, applicable in studies related to retinopathy [1].
价 格：￥电议型 号：T81254产 地：中国大陆
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T81181sEH/FLAP-IN-1；化合物 sEH/FLAP-IN-1sEH/FLAP-IN-1
sEH/FLAP-IN-1 (Compound 46A) serves as a dual inhibitor targeting both sEH and FLAP. It effectively suppresses 5-LOX product formation with an EC50 of 11 nM in SACM-stimulated PBMCs and also inhibits sEH activity (EC50: 18 nM) as well as thromboxane production. This compound is utilized in the study of inflammatory diseases [1].
价 格：￥电议型 号：T81181产 地：中国大陆
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T81175SETD7-IN-1；化合物 SETD7-IN-1SETD7-IN-1
SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitory concentration (IC50) of 0.96 ± 0.10 ?M [1].
价 格：￥电议型 号：T81175产 地：中国大陆
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T81140SNM1A-IN-1；化合物 SNM1A-IN-1SNM1A-IN-1
SNM1A-IN-1 (compound 11a) serves as an inhibitor of the DNA damage repair enzyme SNM1A, exhibiting cytotoxic properties [1].
价 格：￥电议型 号：T81140产 地：中国大陆
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T81114Spns2-IN-1；化合物 Spns2-IN-1Spns2-IN-1
Spns2-IN-1 is a potent Spns2 inhibitor, effectively impeding Spns2-dependent S1P transport with an IC50 value of 1.4±0.3 μM, crucial for modulating the immune response [1].
价 格：￥电议型 号：T81114产 地：中国大陆
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T81109Squalene synthase-IN-1；化合物 Squalene synthase-IN-1Squalene synthase-IN-1
Squalene synthase-IN-1 (compound 1) is a potent antihyperlipidemic agent that inhibits Squalene Synthase and demonstrates exceptional antioxidant and anti-inflammatory activities. It significantly reduces both glucose and oxidative stress levels without causing toxicity [1].
价 格：￥电议型 号：T81109产 地：中国大陆
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T81105SREBP/SCAP-IN-1；化合物 SREBP/SCAP-IN-1SREBP/SCAP-IN-1
SREBP/SCAP-IN-1 (compound 10b) serves as a selective inhibitor of SREBP/SCAP [1].
价 格：￥电议型 号：T81105产 地：中国大陆
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T81104SREBP/SCAP-IN-2；化合物 SREBP/SCAP-IN-2SREBP/SCAP-IN-2
SREBP/SCAP-IN-2 (compound 13) acts as a selective inhibitor of SREBP/SCAP [1].
价 格：￥电议型 号：T81104产 地：中国大陆
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T8108Blu-782；化合物Blu-782ALK2-IN-1；ALK2-IN-1
Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)
价 格：￥电议型 号：T8108产 地：中国大陆
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T81075SUCNR1-IN-2；化合物 SUCNR1-IN-2SUCNR1-IN-2
SUCNR1-IN-2 (Statement 35) serves as an inhibitor of both succinate and succinate receptor 1, utilized in research pertaining to neurodegenerative disorders, including neuroinflammation [1].
价 格：￥电议型 号：T81075产 地：中国大陆
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T81031tau protein/α-synuclein-IN-1；化合物 tau protein/α-synuclein-IN-1tau protein/α-synuclein-IN-1
Tau protein/α-synuclein-IN-1 is a dual inhibitor that not only impedes tau protein and α-synuclein but also reduces the development of α-syn inclusions in M17D neuroblastoma cells, making it a useful agent in the study of Alzheimer´s disease [1].
价 格：￥电议型 号：T81031产 地：中国大陆
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T80921Tubulin/JAK2-IN-1；化合物 Tubulin/JAK2-IN-1Tubulin/JAK2-IN-1
Tubulin/JAK2-IN-1 (compound 7g) serves as a potent dual inhibitor targeting both Janus kinase 2 (JAK2) and microtubules, demonstrating significant antiproliferative effects against cancer cells [1].
价 格：￥电议型 号：T80921产 地：中国大陆
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T80874VEGFR-2/c-Met-IN-1；化合物 VEGFR-2/c-Met-IN-1VEGFR-2/c-Met-IN-1
VEGFR-2/c-Met-IN-1 is a dual inhibitor targeting VEGFR-2 and c-Met with respective IC50 values of 138 nM and 74 nM, demonstrating antitumor activity [1].
价 格：￥电议型 号：T80874产 地：中国大陆
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T80873VEGFR2/HDAC1-IN-1；化合物 VEGFR2/HDAC1-IN-1VEGFR2/HDAC1-IN-1
VEGFR2/HDAC1-IN-1 (compound 13) is a potent dual inhibitor of VEGFR-2 and HDAC, with IC50 values of 57.83 nM for VEGFR-2 and 9.82 nM for HDAC. It arrests the cell cycle at the S and G2 phases and induces apoptosis in HeLa cells, demonstrating an anti-angiogenic effect [1].
价 格：￥电议型 号：T80873产 地：中国大陆
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T80870VE-PTP-IN-1；化合物 VE-PTP-IN-1VE-PTP-IN-1
VE-PTP-IN-1 (compound 2) is a selective inhibitor of the vascular endothelial protein tyrosine phosphatase (VE-PTP), possessing weakly acidic properties. It is associated with the regulation of vascular homeostasis and angiogenesis.
价 格：￥电议型 号：T80870产 地：中国大陆
