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T39299(3S,4S)-PF-06459988；(3S,4S)-PF-06459988(3S,4S)-PF-06459988
(3S, 4S)-PF-06459988 is the less active S enantiomer of PF-06459988, which is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 exhibits excellent selectivity against EGFR wild-type due to its minimally reactive electrophile, which reduces the likelihood of off-target labeling.
价 格：￥电议型 号：T39299产 地：中国大陆
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T39248PF-06426779；PF-06426779PF-06426779
PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4) , with an IC 50 of 0.3 nM.
价 格：￥电议型 号：T39248产 地：中国大陆
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T38816Fmoc-Val-Ala-PAB-PNP；Fmoc-Val-Ala-PAB-PNPFmoc-Val-Ala-PAB-PNP
Fmoc-Val-Ala-PAB-PNP is a cleavable linker employed for the synthesis of antibody-drug conjugates (ADCs).
价 格：￥电议型 号：T38816产 地：中国大陆
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T38798Mal-PFP ester；Mal-PFP esterMal-PFP ester
Mal-PFP ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
价 格：￥电议型 号：T38798产 地：中国大陆
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T38728Biotin-PEG4-PFP ester；Biotin-PEG4-PFP esterBiotin-PEG4-PFP ester；Biotin-PEG4-PFP ester
Biotin-PEG4-PFP ester is a cleavable linker specifically designed for the synthesis of antibody-drug conjugates (ADCs).
价 格：￥电议型 号：T38728产 地：中国大陆
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T38721ALD-PEG4-OPFP；ALD-PEG4-OPFPALD-PEG4-OPFP；ALD-PEG4-OPFP
ALD-PEG4-OPFP is a cleavable ADC linker consisting of four units of PEG. It is specifically formulated for use in the synthesis of antibody-drug conjugates (ADCs).
价 格：￥电议型 号：T38721产 地：中国大陆
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T38709PFM39；化合物 PFM39PFM39
PFM39 is a selective MRE11 nucleic acid exonuclease inhibitor and Mirin analog that prolongs mitosis.PFM39 inhibits HR and alleviates repair defects caused by EXO1/BLM depletion.
价 格：￥电议型 号：T38709产 地：中国大陆
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T38467(Rac)-PF-998425；(Rac)-PF-998425(Rac)-PF-998425
(Rac)-PF-998425 is a potent, selective, nonsteroidal antagonist of the androgen receptor (AR), with IC50 values of 26 nM and 90 nM in AR binding and cellular assays, respectively. This compound shows promise for investigating androgenetic alopecia.
价 格：￥电议型 号：T38467产 地：中国大陆
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T38462PF-04577806；PF-04577806PF-04577806
PF-04577806 is a potent, selective, and ATP competitive inhibitor of the protein kinase C (PKC). It exhibits significant inhibitory activity against various isoforms of PKC, including PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, with IC50 values of 2.4 nM, 8.1 nM, 6.9 nM, 45.9 nM, and 29.5 nM, respectively. Furthermore, PF-04577806 has the ability to reverse retinal vascular leakage in diabetic rats.
价 格：￥电议型 号：T38462产 地：中国大陆
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T38461PF-03622905；PF-03622905PF-03622905
PF-03622905, a potent and ATP-competitive PKC inhibitor, exhibits IC50 values of 5.6 nM, 14.5 nM, 13 nM, 37.7 nM, and 74.1 nM for PKCα, PKCβI, PKCβII, PKCγ, and PKCθ, respectively. Notably, PF-03622905 demonstrates high specificity for PKC in comparison to other protein kinases.
价 格：￥电议型 号：T38461产 地：中国大陆
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T38270PF 5081090；PF 5081090PF 5081090
PF 5081090 has a wide range of applications in life science related research.
价 格：￥电议型 号：T38270产 地：中国大陆
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T38266Nirogacestat dihydrobromidePF 3084014 hydrobromideNirogacestat dihydrobromide
Potent γ-secretase inhibitor (IC50 values are 1.2 and 6.2 nM in whole cell and cell-free assays, respectively). Reduces Aβ in brain, CSF and plasma in mice and guinea pigs.
价 格：￥电议型 号：T38266产 地：中国大陆
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T38099APF；APFAPF
APF is an aromatic amino-fluorescein derivative and fluorescent probe for highly reactive radicals. It has low intrinsic fluorescence, however, upon oxidation by hydroxyl radical, hypochlorite ion, and certain peroxidase intermediates, it is converted to the highly fluorescent molecule fluorescein, facilitating the detection of highly reactive biological radicals. APF is not oxidized by nitric oxide (NO), hydrogen peroxide (H2O2), or other oxidants. Fluorescein displays excitation/emission maxim
价 格：￥电议型 号：T38099产 地：中国大陆
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T38097Antibiotic PF 1052；Antibiotic PF 1052Antibiotic PF 1052
Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also in
价 格：￥电议型 号：T38097产 地：中国大陆
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T38071HPF；HPFHPF
The biology of highly reactive oxygen radical species is of great interest in many biomedical research disciplines, including neurodegeneration, aging, cancer, and infectious diseases.[1] There are a number of fluorescent reagents, such as 2,7-dichlorodihydrofluorescein (DCDHF), that can be used to detect free radicals, but they have significant limitations due to their facile oxidation by light and numerous non-radical oxidants such as hydrogen peroxide (H2O2). [2] HPF is a cell-permeable aroma
价 格：￥电议型 号：T38071产 地：中国大陆
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T37800PF-04449613PF-04449613PF 04449613|||PF04449613
PF-04449613 is a phosphodiesterase 9A (PDE9A) inhibitor (IC50= 22 nM).1It is selective for PDE9A over PDE1C (IC50= >1,000 nM), as well as over a variety of other PDEs, inhibiting PDE2-8, -10, and -11 activity by less than 30% in a panel of enzymes, ion channels, and transporters at 1 μM but does inhibit the human dopamine transporter (DAT; Ki= 293 nM).
价 格：￥电议型 号：T37800产 地：中国大陆
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T37799PF 04671536 hydrochloridePF 04671536 hydrochloridePF 04671536 hydrochloride
Potent and selective PDE8B/8A inhibitor ( IC50 values are 1.3 and 1.9 nM, respectively). Exhibits selectivity for PDE8A/B over other PDEs (IC50 values are >10 μM) and a range of other targets. Increases glucose-dependent insulin secretion from human pacreatic islet cells. Orally bioavailable.
价 格：￥电议型 号：T37799产 地：中国大陆
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T36910PF 04449913 maleatePF 04449913 maleatePF 04449913 maleate
Potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells.
价 格：￥电议型 号：T36910产 地：中国大陆
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T36605(±)5-iPF2α-VI；(±)5-iPF2α-VI(±)5-iPF2α-VI；(±)5-iPF2α-VI
Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes. (±)5-iPF2α-VI is one of dozens of possible stereo- and regioisomeric isoprostanes which can be formed from arachidonic acid. To date, the most extensively studied of these is 8-isoprostane (8-epi-PGF2α, iPF2α-III). However, 8-isoprostane is a minor isoprostane
价 格：￥电议型 号：T36605产 地：中国大陆
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T3637Pifithrin-β hydrobromide；化合物Pifithrin-β hydrobromideCyclic PFT-α|||PFT-β|||Cyclic Pifithrin-α hydrob
Pifithrin-β hydrobromide (Cyclic PFT-α) is an inhibitor of p53; reversibly blocks p53-dependent transcriptional activation and apoptosis. Protects against neuronal death in models of stroke and neurodegenerative disorders. Active in vivo; protects mice from the side-effects of Y therapy associated with p53 induction. Supresses self-renewal of embryonic stem cells. Also aryl hydrocarbon receptor (AHR) agonist, causes upregulation of AHR target gene CYP1A1 (EC50 = 1.1 μM).
价 格：￥电议型 号：T3637产 地：中国大陆
