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T62894AZ-PFKFB3-67 quarterhydrate;化合物 AZ-PFKFB3-67 quarterhydrateAZ-PFKFB3-67 quarterhydrate
AZ-PFKFB3-67 quarterhydrate is a selective and potent inhibitor of the metabolic kinase PFKFB3 kinase, acting on PFKFB3 (IC50: 11 nM), PFKFB2 (IC50: 159 nM) and PFKFB1 (IC50: 1130 nM).
价 格:¥电议型 号:T62894产 地:中国大陆
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T6251PF-04691502;化合物PF04691502PF4691502;PF4691502
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
价 格:¥电议型 号:T6251产 地:中国大陆
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T62356Mardepodect hydrochloride;Mardepodect 盐酸盐PF-2545920 HCl|||Mardepodect HCl|||MP-10 HCl|||PF-02545920
Mardepodect hydrochloride (Mardepodect HCl) is an orally active, selective and potent inhibitor of PDE10A that crosses the blood-brain barrier (IC50: 0.37 nM).Mardepodect hydrochloride up-regulates the expression of proteins encoding specific growth and transcription factors, cell signalling molecules and cell surface proteins. Mardepodect hydrochloride upregulates genes encoding specific growth factors, transcription factors, cell signalling molecules, and cell surface proteins, while downregul
价 格:¥电议型 号:T62356产 地:中国大陆
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T6222PFI-1;化合物PFI1PF-6405761|||PFI 1|||PFI1;PF-6405761|||PFI 1|||PFI1
PFI-1 (PF-6405761), a specific BET (bromodomain-containing protein) inhibitor for BRD4, is with the IC50 of 0.22 μM in a cell-free assay.
价 格:¥电议型 号:T6222产 地:中国大陆
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T62171HDAC8/BRPF1-IN-1;化合物 HDAC8/BRPF1-IN-1HDAC8/BRPF1-IN-1
HDAC8/BRPF1-IN-1 (Compound 23a) is a dual HDAC8 and BRPF1 inhibitor that acts on human HDAC8 (IC50: 443 nM) and human BRPF1 (Kd: 67 nM). HDAC8/BRPF1-IN-1 has low in vitro activity against HDAC1 and 6.
价 格:¥电议型 号:T62171产 地:中国大陆
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T6210Pifithrin-μ;化合物Pifithrin-μPFTμ|||NSC 303580|||2-Phenylethynesulfonamide;PFTμ|||NSC 303580|||2-Phenyl
Pifithrin-μ (NSC-303580) is an inhibitor of p53 and HSP70, with neuroprotective and antitumor activity.
价 格:¥电议型 号:T6210产 地:中国大陆
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T6181UPF 1069;化合物UPF 1069UPF 1069
UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.
价 格:¥电议型 号:T6181产 地:中国大陆
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T6177PF-562271 besylate;化合物PF-562271 besylatePF-00562271 Besylate;PF-00562271 Besylate
PF-562271 besylate (PF-00562271 Besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.
价 格:¥电议型 号:T6177产 地:中国大陆
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T61727HDAC6/8/BRPF1-IN-1;化合物 HDAC6/8/BRPF1-IN-1HDAC6/8/BRPF1-IN-1
HDAC6/8/BRPF1-IN-1 is a dual inhibitor that targets HDAC6, HDAC8, and the bromodomain and PHD finger containing protein 1 (BRPF1). It exhibits inhibitory activity against HDAC1, HDAC6, and HDAC8 with IC50 values of 797 nM, 344 nM, and 908 nM, respectively. In addition, it inhibits BRPF1 with a Kd value of 175.2 nM. This compound is utilized in cancer research [1].
价 格:¥电议型 号:T61727产 地:中国大陆
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T61564PF-03463275;化合物PF-03463275PF-3463275;PF-3463275
PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive deficits associated with schizophrenia.
价 格:¥电议型 号:T61564产 地:中国大陆
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T6127Rucaparib Phosphate;瑞卡帕布磷酸盐AG-014699 phosphate|||PF-01367338|||AG-014699|||PF-01367338 phosphate;AG-
Rucaparib Phosphate (PF-01367338 phosphate) is an inhibitor of PARP (Ki: 1.4 nM for PARP1) that is used in clinical therapy to sensitize cancer cells to chemotherapy.
价 格:¥电议型 号:T6127产 地:中国大陆
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T61213PF-03654764;化合物PF-03654764PF-03654764
PF-03654764 is an orally active, potent, and selective histamine H3 receptor antagonist that inhibits human H3 and rat H3 with Ki values of 1.2 nM and 7.9 nM, respectively.PF-03654764 is often co-administered with Fexofenadine for the treatment of allergic rhinitis.
价 格:¥电议型 号:T61213产 地:中国大陆
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T60921LPF-07038124 HCl(2415085-44-6 Free base);化合物 PF-07038124 HCl(2415085-44-6 Free base)PF-07038124 HCl(2
产品可用于生物细胞实验
价 格:¥电议型 号:T60921L产 地:中国大陆
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T60921PF-07038124;化合物 PF-07038124PF-07038124
PF-07038124 is an inhibitor of PDE4. The IC50 value of PF-07038124 for PDE4B2 is 0.5 nM. PF-07038124 shows inhibitory activities against IFNγ, IL4, and IL-13 with IC50 values of 1.06, 4.1, and 125 nM, respectively [1].
价 格:¥电议型 号:T60921产 地:中国大陆
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T60904ERCC1-XPF-IN-2;化合物ERCC1-XPF-IN-2ERCC1-XPF-IN-2
ERCC1-XPF-IN-2 is active in nucleotide excision repair, cisplatin enhancement and γH2AX assays. ERCC1-XPF-IN-2 is a potent inhibitor of ERCC1-XPF endonuclease with an IC 50 value of 0.6 μM [1].
价 格:¥电议型 号:T60904产 地:中国大陆
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T6085PF-543化合物PF543Sphingosine Kinase 1 Inhibitor II|||PF 543
PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.
价 格:¥电议型 号:T6085产 地:中国大陆
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T60761PF-06305591 dihydrate;化合物 PF-06305591 dihydratePF-06305591 dihydrate
PF-06305591 dihydrate is a potent and highly selective voltage gated sodium channel NaV1.8 blocker (IC 50 = 15 nM) with an excellent preclinical in vitro ADME and safety profile [1].
价 格:¥电议型 号:T60761产 地:中国大陆
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T60629PF-06649298;化合物 PF-06649298PF-06649298
PF-06649298 is an inhibitor of sodium-coupled citrate transporter which specifically interacts with NaCT with an IC 50 value of 16.2 μM to inhibits the transport of citrate in human hepatocytes. PF-06649298 can be used in regulating metabolism of glucose and metabolism of lipid [1] [2].
价 格:¥电议型 号:T60629产 地:中国大陆
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T60621PFM03;化合物 PFM03PFM03
PFM03 is an inhibitor of MRE11 Endonuclease that regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) [1].
价 格:¥电议型 号:T60621产 地:中国大陆
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T60608FPFT-2216;化合物FPFT-2216FPFT-2216
FPFT-2216 is a "molecular glue" compound that degrades IKZF6, IKZF1, DE1D, and CK3α. FPFT-2216 has potential antitumor activity and can be used to study immune system diseases.
价 格:¥电议型 号:T60608产 地:中国大陆