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  • T73005PF-07054894；化合物 PF-07054894PF-07054894

    PF-07054894 is a potent antagonist of the CCR6 and a targeted G protein-coupled receptor (GPCR), useful in the research of inflammatory bowel disease.

    价 格：￥电议型 号：T73005产 地：中国大陆

  • T72999PF-06455943；化合物 PF-06455943PF-06455943

    PF-06455943, a leucine rich repeat kinase 2 (LRRK2) inhibitor, exhibits an inhibition concentration (IC50) value of 3 nM and also functions as a PET radioligand. It is utilized in the research of ADME/neuro PK characterization and Parkinson´s disease (PD).

    价 格：￥电议型 号：T72999产 地：中国大陆

  • T72744(R)-PF-06256142；化合物 (R)-PF-06256142(R)-PF-06256142

    (R)-PF-06256142, the R enantiomer of PF-06256142, exhibits low activity. PF-06256142 itself is distinguished as a potent and selective orthosteric D1 receptor agonist, with the capability to minimize receptor desensitization compared to dopamine and other catechol-containing agonists.

    价 格：￥电议型 号：T72744产 地：中国大陆

  • T72743(R)-PF-04991532；化合物 (R)-PF-04991532(R)-PF-04991532

    (R)-PF-04991532 is the R-enantiomer of PF-04991532 . PF-04991532 is a potent, hepatoselective glucokinase activator .

    价 格：￥电议型 号：T72743产 地：中国大陆

  • T72629PfGSK3/PfPK6-IN-2；化合物 PfGSK3/PfPK6-IN-2PfGSK3/PfPK6-IN-2

    PfGSK3/PfPK6-IN-2, an effective dual inhibitor targeting Plasmodium falciparum GSK3/PK6 (PfGSK3/PfPK6), exhibits potent inhibitory activity with IC50 values of 172 nM for PfGSK3 and 11 nM for PfPK6, respectively. This compound is utilized in malaria research.

    价 格：￥电议型 号：T72629产 地：中国大陆

  • T72221PF-06815345 hydrochloride；化合物 PF-06815345 hydrochloridePF-06815345 hydrochloride

    PF-06815345 hydrochloride, an orally active potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9), has an IC50 value of 13.4 μM. It significantly decreases in vivo PCSK9 levels in mice.

    价 格：￥电议型 号：T72221产 地：中国大陆

  • T72046PF-17；化合物 PF-17PF-17

    PF-17 can be used as a PUF60 inhibitor for the treatment of ovarian cancer.

    价 格：￥电议型 号：T72046产 地：中国大陆

  • T71957Cupferron；化合物 CupferronCupferron

    Cupferron is a superoxide dismutase inhibitor.

    价 格：￥电议型 号：T71957产 地：中国大陆

  • T7163PF-05175157；化合物PF 05175157PF-05175157

    PF 05175157 is an inhibitor of acetyl-CoA carboxylase 1 (ACC1) and ACC2 (IC50s = 27, 33, 23.5, and 50.4 nM for human ACC1, human ACC2, rat ACC1, and rat ACC2, respectively

    价 格：￥电议型 号：T7163产 地：中国大陆

  • T71507PF-4522654；化合物 PF-4522654PF-4522654

    PF-4522654 is a potent and selective 5-HT2C receptor agonist.

    价 格：￥电议型 号：T71507产 地：中国大陆

  • T71506PF-03246799 hydrochloride；化合物 PF-03246799 hydrochloridePF-03246799 hydrochloride

    PF-03246799 hydrochloride is a potent serotonin 5-HT2C receptor agonist.

    价 格：￥电议型 号：T71506产 地：中国大陆

  • T71335PF-3774076；化合物 PF-3774076PF-3774076

    PF-3774076 is a CNS penetrant, potent, selective, partial agonist at the human α1A adrenoceptor. PF-3774076 is selective over α1B and α1D adrenoceptors.

    价 格：￥电议型 号：T71335产 地：中国大陆

  • T71166PF-05150122；化合物 PF-05150122PF-05150122

    PF-05150122 is a novel potent and selective human Nav1.7 blocker.

    价 格：￥电议型 号：T71166产 地：中国大陆

  • T71089PF-00956980；化合物 PF-956980PF-00956980

    PF-00956980 is a reversible pan-JAK inhibitor, exhibiting IC50 values of 2.2 μM for JAK1, 23.1 μM for JAK2, and 59.9 μM for JAK3. It is utilized in the study of lung and skin inflammatory diseases.

    价 格：￥电议型 号：T71089产 地：中国大陆

  • T71020PF-04671536；化合物 PF-04671536PF-04671536

    PF-04671536 is a highly potent and selective inhibitor of phosphodiesterase 8B (PDE8B) phosphodiesterase 8A (PDE8A). In primary human pancreatic islets, PF-04671536 increases insulin secretion in a glucose-dependent manner.

    价 格：￥电议型 号：T71020产 地：中国大陆

  • T70911PF-5177624；化合物 PF-5177624PF-5177624

    PF-5177624 is a selective and potent PDK1 inhibitor inducing anti-tumor activity in breast cancer cells.

    价 格：￥电议型 号：T70911产 地：中国大陆

  • T70896PF05020182；化合物 PF05020182PF05020182

    PF05020182 is novel potent and selective Kv7.2/4 potassium channel opener. PF-05020182 (2) significantly inhibits convulsions in the MES assay at doses tested, consistent with in vitro activity measure. The physiochemical properties, in vitro and in vivo activities of PF-05020182 support further development as an adjunctive treatment of refractory epilepsy. Facilitating activation, or delaying inactivation, of the native Kv7 channel reduces neuronal excitability, which may be beneficial in cont

    价 格：￥电议型 号：T70896产 地：中国大陆

  • T70826PF-03671148；化合物 PF-03671148PF-03671148

    PF-03671148 is a potent ALK inhibitor. PF-03671148 inhibits the expression of fibrotic genes and protein markers both in vitro in human fibroblasts and in vivo in a rat wound repair model. Wound healing is not inhibited by the topical application of the ALK5 inhibitor to the wound. PF-03671148 may have potential utility for the prevention of dermal scarring.

    价 格：￥电议型 号：T70826产 地：中国大陆

  • T70812PF-05236216 hydrochloride；化合物 PF-05236216 hydrochloridePF-05236216 hydrochloride

    PF-05236216 hydrochloride is a brain penetrant, potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε) that modulates circadian rhythms in mice.

    价 格：￥电议型 号：T70812产 地：中国大陆

  • T70782PF-05139962；化合物 PF-05139962PF-05139962

    PF-05139962 is a novel potent mTOR inhibitor with excellent mTOR biochemical inhibition, cellular potency, kinase selectivity and in vitro ADME properties. PF-05139962 has pS473 and pS6 cellular IC50 = 48 and 6 nM respectively. PF-05139962 has great selectivity against other receptors and kinases. No genotoxicity was observed on this compound and no more than 25% inhibiton was observed for major CYP enzymes (3A4, 1A2, 2C9, 2D6) at 3 uM. This compound has LE = 0.35 and LipE up to 6.8 which is in

    价 格：￥电议型 号：T70782产 地：中国大陆

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