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  • T78432Suc-AAPF-pNA；化合物 Suc-AAPF-pNASuc-Ala-Ala-Pro-Phe-pNA；Suc-Ala-Ala-Pro-Phe-pNA

    Suc-AAPF-pNA (Suc-Ala-Ala-Pro-Phe-pNA), a chromogenic p-nitroanilide (pNA) substrate, exhibits a Km of 1.7 mM and is utilized for assessing both free and membrane-bound cathepsin G in human neutrophils [1].

    价 格：￥电议型 号：T78432产 地：中国大陆

  • T78282Tanezumab；化合物 TanezumabRN-624|||PF 4383119；RN-624|||PF 4383119

    Tanezumab (RN-624) is a high-affinity, specific humanized anti-NGF monoclonal antibody (mAb) that inhibits nerve growth factor (NGF) from binding to its p75 and TrkA receptors in the peripheral nervous system. It is utilized in research investigating both acute and chronic pain conditions, including osteoarthritis, knee pain, neuralgia, and post-herpetic neuralgia [1] [2].

    价 格：￥电议型 号：T78282产 地：中国大陆

  • T77932PF15 TFA；化合物 PF15 TFAPF15 TFA

    PF15 TFA, a PROTAC targeting FLT3 kinase and CRBN, exhibits selective degradation of FLT3-ITD with a DC50 of 76.7 nM. The compound potently suppresses proliferation in FLT3-ITD-positive cells, reduces phosphorylation levels of FLT3 and STAT5, and demonstrates inhibition of tumor growth in murine leukemia models [1].

    价 格：￥电议型 号：T77932产 地：中国大陆

  • T77831Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP；化合物 Fmoc-Glu-(Boc)-Val-Cit-PAB-PNPFmoc-Glu-(Boc)-Val-Cit-PAB-PNP

    Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a cleavable linker utilized in antibody-drug conjugate (ADC) synthesis, facilitating the attachment and subsequent release of therapeutics from antibodies [1].

    价 格：￥电议型 号：T77831产 地：中国大陆

  • T77781Lotiglipron；化合物 LotiglipronPF-07081532；PF-07081532

    Lotiglipron (PF-07081532) is an orally active and potent GLP-1R agonist that reduces blood glucose and body weight and may be useful in the study of type 2 diabetes mellitus (T2DM) and obesity.

    价 格：￥电议型 号：T77781产 地：中国大陆

  • T7767FMoc-Val-Cit-PAB-PNP；化合物FMoc-Val-Cit-PAB-PNPFMocValCitPABPNP|||ADC Linkers|||inhibit|||Antibody-drug

    Fmoc-Val-Cit-PAB-PNP is a linker for Antibody-Drug-Conjugation (ADC).

    价 格：￥电议型 号：T7767产 地：中国大陆

  • T7729PF-06454589；化合物PF-06454589PF-06454589

    PF-06454589 is a potent inhibitor of LRRK2.

    价 格：￥电议型 号：T7729产 地：中国大陆

  • T76858Ascrinvacumab；阿伐苏单抗PF-03446962；PF-03446962

    Ascrinvacumab (PF-03446962) is a highly humanized IgG2 monoclonal antibody against ALK-1. Ascrinvacumab has a Kd value of 7 nM for human ALK1. Ascrinvacumab has an inhibitory effect on TGF-β and can be used to study hepatocellular carcinoma (HCC).

    价 格：￥电议型 号：T76858产 地：中国大陆

  • T76774Ponsegromab；Ponsegromab单抗PF 06946860；PF 06946860

    Ponsegromab (PF 06946860) is a selective and effective humanized anti-GDF15 antibody inhibitor. Ponsegromab has anti-cachexic activity by binding to GDF15 to prevent its binding to GFRAL, thus disrupting GDF15/GFRAL mediated signaling. Ponsegromab has potential anticancer activity and can be used to treat cancer patients with cancer anorexia cachexia syndrome.

    价 格：￥电议型 号：T76774产 地：中国大陆

  • T76739Bococizumab；伯考赛珠单抗RN316|||PF-04950615；RN316|||PF-04950615

    Bococizumab(PF-04950615) is a humanized mAb against PCSK9 and an inhibitor of the synthesis of PCSK9 in the liver that reduces the amount of low-density lipoprotein cholesterol (LDL-C) in the blood.Bococizumab is used to treat hypercholesterolemia.

    价 格：￥电议型 号：T76739产 地：中国大陆

  • T76705Utomilumab乌托鲁单抗PF 05082566|||PF-2566

    Utomilumab (PF 05082566) is a humanized IgG2 antibody targeting the T-cell co-stimulatory receptor 4-1BB/CD137 and a 4-1BB/CD137 agonist.Utomilumab has antitumor activity and may be used in the study of patients with advanced malignancies.

    价 格：￥电议型 号：T76705产 地：中国大陆

  • T7502LPF 05089771；化合物PF-05089771PF-05089771|||PF05089771；PF-05089771|||PF05089771

    PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.

    价 格：￥电议型 号：T7502L产 地：中国大陆

  • T7502PF 05089771 tosylate；化合物PF 05089771 tosylatePF 05089771 tosylate

    PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50: 0.11-25 μM), L-type calcium, and KvLQT and hERG potassium channels (IC50: ≥10 μM), as well as human and cynomolgus monkey TRPV1 receptors (IC50: 10/20 μM). PF-05089771 is also 1, 000-fold selective for half-inactivated over resting Nav1.7 channels, and mutation o

    价 格：￥电议型 号：T7502产 地：中国大陆

  • T74292Fluorescent DOTAP；化合物 Fluorescent DOTAPFluorescent DOTAP

    Fluorescent DOTAP, a cationic lipid, facilitates research in nucleic acid and protein delivery [1].

    价 格：￥电议型 号：T74292产 地：中国大陆

  • T74271TRIM24/BRPF1-IN-2；化合物 TRIM24/BRPF1-IN-2TRIM24/BRPF1-IN-2

    TRIM24/BRPF1-IN-2 (compound 20l) is an effective dual inhibitor of TRIM24/BRPF1, demonstrating IC50 values of 0.98 μM for TRIM24 and 1.16 μM for BRPF1, respectively. It exhibits strong binding affinity to the bromodomains of TRIM24/BRPF1, making it a valuable tool for prostate cancer research [1].

    价 格：￥电议型 号：T74271产 地：中国大陆

  • T74259PF15；化合物 PF15PF15

    PF15, a selective FLT3-ITD degrader, serves as a PROTAC (proteolysis targeting chimera) tethering ligands for FLT3 kinase and CRBN. It exhibits a degradation concentration 50 (DC50) of 76.7 nM and notably impedes the proliferation of FLT3-ITD-positive cells. PF15 also reduces phosphorylation levels of FLT3 and STAT5 and demonstrates efficacy in inhibiting tumor growth in mouse models, suggesting potential applications in leukemia research [1].

    价 格：￥电议型 号：T74259产 地：中国大陆

  • T7419Sutezolid；化合物SutezolidPNU-100480|||U-100480|||PF-02341272；PNU-100480|||U-100480|||PF-02341272

    Sutezolid (U-100480) is an oxazolidinone antimicrobial for the treatment of tuberculosis.

    价 格：￥电议型 号：T7419产 地：中国大陆

  • T73846PF-06456384 trihydrochloride；化合物 PF-06456384 trihydrochloridePF-06456384 trihydrochloride

    PF-06447475 trihydrochloride is a potent, selective LRRK2 kinase inhibitor that demonstrates excellent brain penetration, exhibiting IC50 values of 3 nM for wild-type LRRK2 and 11 nM for G2019S LRRK2 variants. It holds potential for Parkinson´s disease (PD) research [1].

    价 格：￥电议型 号：T73846产 地：中国大陆

  • T73470PF-184；化合物 PF-184PF-184

    PF-184 is a potent, selective inhibitor of IKK-2 with an IC50 value of 37 nM, demonstrating significant selectivity over rhIKK-1, IKKi, and over 30 other tyrosine and serine/threonine kinases. It is utilized in inflammation research, including studies on asthma and chronic obstructive pulmonary disease.

    价 格：￥电议型 号：T73470产 地：中国大陆

  • T7343PF-04979064；化合物PF-04979064PF-04979064

    PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).

    价 格：￥电议型 号：T7343产 地：中国大陆

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