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T81991Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside;化合物 Kaempferol-3-O-[2″,6″-di-O-E-p-cou
Kaempferol-3-O-[2″,6″-di-O-E-p-coumaroyl]-β-D-glucopyranoside, an acylated kaempferol glucoside, can be extracted from the leaves of O. dentata and functions as a repellent to the fouling organism, the blue mussel M. edulis [1].
价 格:¥电议型 号:T81991产 地:中国大陆
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T81990Kaempferol-3-O-robinoside-7-O-glucoside;化合物 Kaempferol-3-O-robinoside-7-O-glucosideKaempferol-3-O-ro
Kaempferol-3-O-robinobioside-7-O-glucoside, a biflavonoid triglycoside, can be isolated from Withania somnifera [1].
价 格:¥电议型 号:T81990产 地:中国大陆
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T81854Marstacimab;化合物 MarstacimabPF-06741086;PF-06741086
Marstacimab (PF-06741086), an anti-tissue factor pathway inhibitor (TFPI) monoclonal antibody, is utilized in hemophilia research [1] [2].
价 格:¥电议型 号:T81854产 地:中国大陆
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T81822MeOSuc-AAPF-CMK;化合物 MeOSuc-AAPF-CMKMeOSuc-Ala-Ala-Pro-Phe-CH?Cl;MeOSuc-Ala-Ala-Pro-Phe-CH?Cl
MeOSuc-AAPF-CMK (MeOSuc-Ala-Ala-Pro-Phe-CH2Cl) is a potent inhibitor of the enzyme proteinase K [1].
价 格:¥电议型 号:T81822产 地:中国大陆
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T81501PF-06655075 TFA;化合物 PF-06655075 TFAPF-06655075 TFA
PF-06655075 (TFA) is the trifluoroacetic acid (TFA) salt of PF-06655075, a novel, non-brain-penetrant oxytocin receptor agonist that exhibits enhanced selectivity for the oxytocin receptor and improved pharmacokinetic stability. It serves as a valuable tool compound for investigating the influence of peripheral oxytocin on behavioral responses [1].
价 格:¥电议型 号:T81501产 地:中国大陆
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T81500PF-07059013;化合物 PF-07059013PF-07059013
PF-07059013, an orally active and potent noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity and demonstrates substantial partitioning into red blood cells (RBCs), making it useful for sickle cell disease (SCD) research [1][2].
价 格:¥电议型 号:T81500产 地:中国大陆
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T80878Vanutide cridificar;化合物 Vanutide cridificarPF 05236806|||ACC-001;PF 05236806|||ACC-001
Vanutide cridificar (ACC-001) is an aminoterminal Aβ1-7 peptide conjugate, employed in Alzheimer’s disease (AD) research [1].
价 格:¥电议型 号:T80878产 地:中国大陆
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T80743Z-APF-CMK;化合物 Z-APF-CMKZ-APF-CMK
Z-APF-CMK is a selective inhibitor of the calcium (Ca2+)-regulated nuclear scaffold protease (CRNSP), as reported in reference [1].
价 格:¥电议型 号:T80743产 地:中国大陆
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T80735Z-Gly-Pro-Phe-Leu-CHO;化合物 Z-Gly-Pro-Phe-Leu-CHOZ-GPFL-CHO;Z-GPFL-CHO
Z-Gly-Pro-Phe-Leu-CHO (Z-GPFL-CHO) is a tetrapeptide aldehyde serving as a selective and potent proteasome inhibitor, demonstrating inhibition constants (Ki) of 1.5 ?M, 2.3 ?M, and 40.5 ?M for branched-chain amino acid-preferred, small neutral amino acid-preferred, and chymotrypsin-like activities, respectively, and an inhibitory concentration (IC50) of 3.1 ?M for peptidyl-glutamyl peptide hydrolyzing activity [1].
价 格:¥电议型 号:T80735产 地:中国大陆
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T80611Sasanlimab;化合物 SasanlimabPF-06801591;PF-06801591
Sasanlimab (PF-06801591), a humanized IgG4-κ antibody, selectively targets PD-1 and is primarily produced in Chinese Hamster Ovary (CHO) cells [1].
价 格:¥电议型 号:T80611产 地:中国大陆
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T79867Ibuzatrelvir;化合物 IbuzatrelvirPF-07817883;PF-07817883
Ibuzatrelvir (PF-07817883) is an antiviral compound designed to inhibit the SARS-CoV-2 3CL protease, and is utilized in the treatment of COVID-19 [1].
价 格:¥电议型 号:T79867产 地:中国大陆
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T79764PF-07202954;化合物 PF-07202954PF-07202954
PF-07202954, a weakly basic diacylglycerol O-acyltransferase 2 (DGAT2) inhibitor, exhibits an inhibition concentration half-maximum (IC50) of 10 nM against human DGAT2 and effectively reduces liver triglyceride content in a rat model fed on a Western diet [1].
价 格:¥电议型 号:T79764产 地:中国大陆
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T79755PF-07208254;化合物 PF-07208254PF-07208254
PF-07208254, a potent BDK inhibitor, enhances cardiometabolic endpoints in mice [1].
价 格:¥电议型 号:T79755产 地:中国大陆
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T79358PF-07247685;化合物 PF-07247685PF-07247685
PF-07247685, a potent BCKDC kinase (BDK) inhibitor (EC 50 = 2.2 nM), enhances the binding between BDK and the BCKDH E2 core subunit to block E1 phosphorylation. BDK regulation is crucial for BCKDH activity, which manages the rate-limiting step in the catabolism of branched-chain amino acids (BCAA). Dysfunctional BCAA metabolism is linked to various cardiometabolic disorders such as heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-072
价 格:¥电议型 号:T79358产 地:中国大陆
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T79357PF-07238025;化合物 PF-07238025PF-07238025
PF-07238025, a potent branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with an EC50 of 19 nM, enhances the stability of the BDK-BCKDH core E2 subunit interaction and inhibits the phosphorylation of the E1 subunit. By modulating BDK, which regulates the phosphorylation of BCKDH, a key enzyme in branched-chain amino acid (BCAA) degradation, PF-07238025 indirectly controls the rate-limiting step in BCAA catabolism. Dysregulated BCAA metabolism is implicated in various cardiometabolic di
价 格:¥电议型 号:T79357产 地:中国大陆
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T79174PF-06478939 TFA;化合物 PF-06478939 TFAPF-06478939 TFA
PF-06478939 TFA is a peptide that acts as a non-brain-penetrating agonist at the oxytocin (OT) and vasopressin receptors, exhibiting EC50 values of 0.01 nM and 0.078 nM, respectively [1].
价 格:¥电议型 号:T79174产 地:中国大陆
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T79173PF-06478939;化合物 PF-06478939PF-06478939
PF-06478939 is a peptide that functions as an agonist at the oxytocin (OT) receptor and vasopressin receptor without crossing the blood-brain barrier. It exhibits EC50 values of 0.01 nM at the OT receptor and 0.078 nM at the vasopressin receptor [1].
价 格:¥电议型 号:T79173产 地:中国大陆
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T79172PF-06655075;化合物 PF-06655075PF-06655075
PF-06655075 is a novel, non-brain-penetrant oxytocin receptor agonist that demonstrates enhanced selectivity for the oxytocin receptor and substantially improved pharmacokinetic stability. This compound serves as a tool to further investigate the function of peripheral oxytocin in behavioral responses [1].
价 格:¥电议型 号:T79172产 地:中国大陆
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T79123PF-07284892;化合物 PF-07284892ARRY-558;ARRY-558
PF-07284892 (ARRY-558) is an orally active, potent inhibitor of SHP2, demonstrating an IC50 of 21 nM, and is known to reduce the expression of pERK [1] [2].
价 格:¥电议型 号:T79123产 地:中国大陆
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T78455Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2;化合物 Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2Ru(bpy)2(mcbpy-O-Su-ester)(PF6)
Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 is a potent ruthenium-based dye that serves as an effective quencher for quantum dots (QDs) fluorescence and as a capture probe for the virus antigen EV71. Additionally, it can be utilized as a sensitive label for electrogenerated chemiluminescence (ECL) detection of matrix metalloproteinases (MMPs) [1] [2] [3].
价 格:¥电议型 号:T78455产 地:中国大陆