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  • T61762Zika virus-IN-3；化合物 Zika virus-IN-3Zika virus-IN-3

    Zika virus-IN-3 (Compd 7) is a Zika virus inhibitor, with an EC 50 of 3.4 μM [1].

    价 格：￥电议型 号：T61762产 地：中国大陆

  • T61751DNA-PK-IN-3；化合物 DNA-PK-IN-3DNA-PK-IN-3

    DNA-PK-IN-3 is a highly potent inhibitor of DNA-PK. This compound exerts a synergistic effect when combined with radiotherapy and chemotherapy, resulting in enhanced therapeutic outcomes and significant inhibition of tumor growth. Furthermore, DNA-PK-IN-3 demonstrates remarkable efficacy in reducing damage to normal cells, effectively minimizing adverse side effects. Due to these compelling properties, DNA-PK-IN-3 holds great potential for cancer research applications[1].

    价 格：￥电议型 号：T61751产 地：中国大陆

  • T61686Steroid sulfatase-IN-3；化合物 Steroid sulfatase-IN-3Steroid sulfatase-IN-3

    Steroid sulfatase-IN-3 (compound 1q) is a highly effective Steroid sulfatase (STS) inhibitor, exhibiting an IC 50 value of 25.8 nM. This compound also demonstrates antiproliferative properties against T-47D estrogen-dependent breast cancer cells, with an IC 50 of 1.04 μM [1].

    价 格：￥电议型 号：T61686产 地：中国大陆

  • T61675CHIKV-IN-3；化合物 CHIKV-IN-3CHIKV-IN-3

    CHIKV-IN-3 is a potent inhibitor effective against two low-passage CHIKV strains, demonstrating EC50 values of 1.55 μM for CHIKV-122508 and 0.14 μM for CHIKV-6708, respectively. It operates by targeting host cells to disrupt viral replication, while maintaining a minimal cytotoxic liability (CC50 > 100 μM). Additionally, CHIKV-IN-3 has shown a prophylactic effect [1].

    价 格：￥电议型 号：T61675产 地：中国大陆

  • T61660FGFR-IN-3；化合物 FGFR-IN-3FGFR-IN-3

    FGFR-IN-3 (compound 6) is a highly potent and orally active modulator of FGFR (fibroblast growth factor receptor). It has the ability to penetrate the blood-brain barrier (BBB). Additionally, FGFR-IN-3 exhibits significant neuroprotective properties. Therefore, it holds potential for research on neurodegenerative diseases [1].

    价 格：￥电议型 号：T61660产 地：中国大陆

  • T61632Glucosylceramide synthase-IN-3；化合物 Glucosylceramide synthase-IN-3Glucosylceramide synthase-IN-3

    Glucosylceramide synthase-IN-3 (compound BZ1) is a highly potent, brain-penetrant, and orally active inhibitor of glucosylceramide synthase (GCS), exhibiting an IC50 value of 16 nM for human GCS. This compound, designated as Glucosylceramide synthase-IN-3, finds potential applications in Gaucher´s disease research [1] [2].

    价 格：￥电议型 号：T61632产 地：中国大陆

  • T61618PI3K-IN-38；PI3K抑制剂38PI3K-IN-38

    PI3K-IN-38 is an orally available and potent PI3K inhibitor with an IC50 value of 0.541 ?M for PI3K-α. PI3K-IN-38 exhibits anticancer and anti-inflammatory activity and inhibits tumor growth in vivo.

    价 格：￥电议型 号：T61618产 地：中国大陆

  • T61584ASK1-IN-3；化合物 ASK1-IN-3ASK1-IN-3

    ASK1-IN-3 is a highly potent and selective inhibitor of ASK1 kinase, demonstrating an IC 50 of 33.8 nM. This compound also exhibits inhibitory effects on various cell cycle regulating kinases. ASK1-IN-3 showcases remarkable induction of apoptosis in HepG2 cancer cells and displays potent activity in arresting the cell cycle [1].

    价 格：￥电议型 号：T61584产 地：中国大陆

  • T61568Vanin-1-IN-3；化合物 Vanin-1-IN-3Vanin-1-IN-3

    Vanin-1-IN-3 (OMP-7) is a vanin-1 inhibitor with an IC 50 of 0.038 μM [1].

    价 格：￥电议型 号：T61568产 地：中国大陆

  • T61565KDM5B-IN-3；化合物 KDM5B-IN-3KDM5B-IN-3

    KDM5B-IN-3 (Compound 5) is an inhibitor of histone lysine-specific demethylase 5B (KDM5B) or JARID1B. It effectively inhibits the activity of KDM5B with an IC50 value of 9.32 μM. Consequently, KDM5B-IN-3 serves as a valuable tool in gastric cancer research [1].

    价 格：￥电议型 号：T61565产 地：中国大陆

  • T61552ATG7-IN-3；化合物 ATG7-IN-3ATG7-IN-3

    ATG7-IN-3 (compound 18) is an effective inhibitor of ATG7, with a potency of 0.048 μM as determined by its IC50 value. It exhibits inhibitory actions on autophagy. Moreover, ATG7-IN-3 effectively hampers the development of endogenous LC3B puncta in the H4 neuroglioma cell line [1].

    价 格：￥电议型 号：T61552产 地：中国大陆

  • T61546c-ABL-IN-3；化合物 c-ABL-IN-3c-ABL-IN-3

    c-ABL-IN-3, a highly effective c-Abl inhibitor, exhibits promising potential for studying neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and Parkinson´s disease (PD), as well as cancer [1]. The activation of c-Abl has been strongly implicated in a range of diseases, notably cancer [1]. It offers valuable opportunities for research in these fields [1].

    价 格：￥电议型 号：T61546产 地：中国大陆

  • T61480NHE3-IN-3；化合物 NHE3-IN-3NHE3-IN-3

    NHE3-IN-3 (Compound 1) is a potent inhibitor of the isoform 3 of the Na+/H+ exchanger (NHE3). It exhibits pIC50 values of 6.2 and 6.6 against human and rat NHE3, respectively. Furthermore, NHE3-IN-3 showcases exceptional oral bioavailability of 98% in Sprague–Dawley rats [1].

    价 格：￥电议型 号：T61480产 地：中国大陆

  • T61479LOX-IN-3 dihydrochloride monohydrate；化合物 LOX-IN-3 dihydrochloride monohydrateLOX-IN-3 dihydrochlorid

    LOX-IN-3 dihydrochloride monohydrate (Compound 33) is a lysyl oxidase (LOX) inhibitor with oral activity. It is specifically designed for research purposes in the areas of fibrosis, cancer, and angiogenesis [1].

    价 格：￥电议型 号：T61479产 地：中国大陆

  • T61466PptT-IN-3；化合物 PptT-IN-3PptT-IN-3

    PptT-IN-3 (compound 5p) is a powerful inhibitor (IC 50 = 3.5 μM) of phosphopantetheinyl phosphoryl transferase (PptT), an indispensable enzyme involved in the synthesis of cellular lipids and virulence factors in Mycobacterium tuberculosis. This compound, PptT-IN-3, holds promise for tuberculosis research [1].

    价 格：￥电议型 号：T61466产 地：中国大陆

  • T61460Tyrosinase-IN-3；化合物 Tyrosinase-IN-3Tyrosinase-IN-3

    Tyrosinase-IN-3 (compound 54) is a powerful tyrosinase inhibitor, an enzyme involved in the key catalytic step of melanin biosynthesis and enzymatic browning. As a copper-containing metalloenzyme, tyrosinase plays a crucial role in these processes. The compound shows promise for studying skin whitening agents and food preservatives [1].

    价 格：￥电议型 号：T61460产 地：中国大陆

  • T61429HDAC-IN-33；化合物 HDAC-IN-33HDAC-IN-33

    HDAC-IN-33 is a highly potent HDAC inhibitor, effectively inhibiting HDAC1, HDAC2, and HDAC6 with IC50 values of 24, 46, and 47 nM, respectively. This compound demonstrates significant antiproliferation activity against tumor cells and exhibits remarkable in vivo antitumor efficacy. Additionally, HDAC-IN-33 initiates the activation of antitumor immunity [1].

    价 格：￥电议型 号：T61429产 地：中国大陆

  • T61403Plasma kallikrein-IN-3；化合物 Plasma kallikrein-IN-3Plasma kallikrein-IN-3

    Plasma kallikrein-IN-3, a potent inhibitor ( IC 50 : 0.15 μM) of plasma kallikrein, finds application in research related to hereditary angioedema, diabetic macular edema, and diabetic retinopathy [1].

    价 格：￥电议型 号：T61403产 地：中国大陆

  • T61362CDK5-IN-3；化合物 CDK5-IN-3CDK5-IN-3

    CDK5-IN-3 (compound 11) is a highly potent and selective inhibitor of CDK5, demonstrating significant inhibition with IC50 values of 0.6 nM and 18 nM for CDK5/p25 and CDK2/CycA, respectively. This compound holds promise for further investigation in the context of autosomal dominant polycystic kidney disease (ADPKD) research [1].

    价 格：￥电议型 号：T61362产 地：中国大陆

  • T61352COX-2/5-LOX-IN-3；化合物 COX-2/5-LOX-IN-3COX-2/5-LOX-IN-3

    COX-2/5-LOX-IN-3 (compound 5b) is a powerful and dual inhibitor of COX-2 and 5-LOX, with IC50 values of 45.73 μM, 5.45 μM, and 4.33 μM for COX-1, COX-2, and 5-LOX, respectively. This compound, COX-2/5-LOX-IN-3, shows promise for the investigation of inflammatory diseases [1].

    价 格：￥电议型 号：T61352产 地：中国大陆

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