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  • T62962Axl-IN-3；化合物 Axl-IN-3Axl-IN-3

    Axl-IN-3 is a selective, potent and orally active inhibitor of AXL kinase (IC50: 41.5 nM) and has a low inhibitory effect on other kinases.

    价 格：￥电议型 号：T62962产 地：中国大陆

  • T62958SARS-CoV-2-IN-31；化合物 SARS-CoV-2-IN-31SARS-CoV-2-IN-31

    SARS-CoV-2-IN-31 is a potent inhibitor of COVID-19. SARS-CoV-2-IN-31 shows excellent to mild activity (IC50: 28.84-38.36 μM) against a variety of cancer cell lines. SARS-CoV-2-IN-31 can be used in cancer research.

    价 格：￥电议型 号：T62958产 地：中国大陆

  • T62941Bcl-2/Mcl-1-IN-3；化合物 Bcl-2/Mcl-1-IN-3Bcl-2/Mcl-1-IN-3

    Bcl-2/Mcl-1-IN-3 is a Bcl-2/Mcl-1 inhibitor that acts on Mcl-1 (Ki: 0.14 μM) and Bcl-2 (Ki: 0.23 μM) and can be used in cancer research.

    价 格：￥电议型 号：T62941产 地：中国大陆

  • T62920HDAC-IN-38；化合物 HDAC-IN-38HDAC-IN-38

    HDAC-IN-38 is a potent inhibitor of HDAC. HDAC-IN-38 has similar micromolar inhibitory effects on HDAC1, 2, 3, 5, 6 and 8, and also increases histone acetylation levels (H3K14 or H4K5). HDAC-IN-38 increases cerebral blood flow (CBF), reduces cognitive impairment and improves hippocampal atrophy.

    价 格：￥电议型 号：T62920产 地：中国大陆

  • T62897MtTMPK-IN-3；化合物 MtTMPK-IN-3MtTMPK-IN-3

    MtTMPK-IN-3 (compound 25) is a potent inhibitor of Mycobacterium tuberculosis thymidylate kinase (MtTMPK) with an IC50 value of 0.12 μM. It also demonstrates inhibitory activity against Mtb H37Rv with a MIC of 12.5 μM and exhibits a degree of cytotoxicity in MRC-5 human fibroblast cells (EC50 = 12.5 μM). This compound is useful for tuberculosis research [1].

    价 格：￥电议型 号：T62897产 地：中国大陆

  • T62875NF-κB-IN-3；化合物 NF-κB-IN-3NF-κB-IN-3

    NF-κB-IN-3 (Compound 2) is an NF-κB inhibitor (IC50: 0.70 μM) and can be used as an anti-tumour agent.

    价 格：￥电议型 号：T62875产 地：中国大陆

  • T62862CK2-IN-3；化合物 CK2-IN-3CK2-IN-3

    CK2-IN-3 is a potent and selective CK2 inhibitor (Kd: 12 nM) with IC50 values of 1.51 μM for CK2α and 7.64 μM for CK2α´. CK2-IN-3 can be used in cancer research.

    价 格：￥电议型 号：T62862产 地：中国大陆

  • T62837Influenza virus-IN-3；化合物 Influenza virus-IN-3Influenza virus-IN-3

    Influenza virus-IN-3 (compound 9) is a potent inhibitor of selective influenza viruses, acting on H5N1 (IC50: 0.88 μM), H5N2 (IC50: 0.10 μM), H5N6 (IC50: 5.5 μM), H5N8 (IC50: 0.51 μM). Influenza virus-IN-3 has antiviral and NA (neuraminidase) inhibitory effects and low cytotoxicity (CC50>200 μM).

    价 格：￥电议型 号：T62837产 地：中国大陆

  • T62824FLT3/ITD-IN-3；化合物 FLT3/ITD-IN-3FLT3/ITD-IN-3

    FLT3/ITD-IN-3 (Compound 19) is a potent inhibitor of FLT3-ITD, acting on FLT3D835Y (IC50: 0.3 nM), FLT3 (IC50: 0.4 nM) and FLT3-ITD (IC50: 0.9 nM). FLT3/ITD-IN-3 showed potent inhibition of FLT3 phosphorylation and was effective against the proliferation of AML cells.

    价 格：￥电议型 号：T62824产 地：中国大陆

  • T62786HDAC1-IN-3；化合物 HDAC1-IN-3HDAC1-IN-3

    HDAC1-IN-3 is a potent inhibitor of Pf HDAC1. HDAC1-IN-3 is antimalarial in both wild-type and multidrug-resistant strains of the parasite. HDAC1-IN-3 exhibits a significant in vivo killing effect on all life cycles of the parasite.

    价 格：￥电议型 号：T62786产 地：中国大陆

  • T62779PI3K-IN-35；化合物 PI3K-IN-35PI3K-IN-35

    PI3K-IN-35 (Compound 6l) is a highly selective inhibitor of PI3K, acting on PI3K-α (IC50: 13.98 μM), PI3K-β (IC50: 7.22 μM) and PI3K-δ (IC50: 10.94 μM). PI3K-IN-35 blocks the cell cycle in G2/M phase and induces apoptosis. PI3K-IN-35 can be used to study leukaemia.

    价 格：￥电议型 号：T62779产 地：中国大陆

  • T62777EGFR/HER2-IN-3；化合物 EGFR/HER2-IN-3EGFR/HER2-IN-3

    EGFR/HER2-IN-3 (Compound ZINC21942954) is a dual EGFR and HER2 inhibitor.

    价 格：￥电议型 号：T62777产 地：中国大陆

  • T62760ROMK-IN-32；化合物 ROMK-IN-32ROMK-IN-32

    ROMK-IN-32 is an inhibitor of the extra-renal medullary potassium channel (ROMK) (IC50: 35 nM) and also inhibits hERG (IC50: 22 μM).

    价 格：￥电议型 号：T62760产 地：中国大陆

  • T62745AMPK-IN-3；AMPK抑制剂3AMPK-IN-3

    AMPK-IN-3 is a novel, selective and potent AMPK inhibitor with inhibitory effects on AMPK (α2), AMPK (α1) and KDR, with IC50 values of 60.7, 107 and 3820 nM, respectively.AMPK-IN-3 showed anticancer activity in K562 cells.

    价 格：￥电议型 号：T62745产 地：中国大陆

  • T62718RSK2-IN-3；化合物 RSK2-IN-3RSK2-IN-3

    RSK2-IN-3 (Compound 26) is a covalent, reversible inhibitor of RPS6KA3 (RSK2) kinase.

    价 格：￥电议型 号：T62718产 地：中国大陆

  • T62708HDAC-IN-37；化合物 HDAC-IN-37HDAC-IN-37

    HDAC-IN-37 is a potent inhibitor of HDAC, acting on HDAC1 (IC50: 0.0551 μM), HDAC3 (IC50: 1.24 μM), HDAC8 (IC50: 0.948 μM) and HDAC6 (IC50: 34.2 μM). HDAC-IN-37 is able to slowly induce histone acetylation. HDAC-IN-37 prevents the transition from G1 to S phase and induces early apoptosis.

    价 格：￥电议型 号：T62708产 地：中国大陆

  • T62697BuChE-IN-3；化合物 BuChE-IN-3BuChE-IN-3

    BuChE-IN-3 (Compound C4) is a potent inhibitor of BuChE (IC50: 8.3 nM). buChE-IN-3 is a mild antioxidant, non-toxic, lipophilic and neuroprotective agent.

    价 格：￥电议型 号：T62697产 地：中国大陆

  • T62683PRMT5-IN-3；化合物 PRMT5-IN-3PRMT5-IN-3

    PRMT5-IN-3 is a PRMT5 inhibitor.PRMT5-IN-3 is a combined DNA damaging agent that is synthetically lethal to tumor cells.

    价 格：￥电议型 号：T62683产 地：中国大陆

  • T62681PDE5-IN-3；化合物 PDE5-IN-3PDE5-IN-3

    PDE5-IN-3 (compound 11j) is a potent inhibitor of PDE5 (IC50: 1.57 nM). PDE5-IN-3 has a moderate inhibitory effect on EGFR (IC50: 5.827 μM). PDE5-IN-3 markedly inhibits the Wnt/β-catenin pathway with an IC50 value of 1286.96 ng/mL. PDE5-IN-3 induced the intrinsic apoptotic mitochondrial pathway in HepG2 cells, and PDE5-IN-3 exhibited significant antitumor effects.

    价 格：￥电议型 号：T62681产 地：中国大陆

  • T62671FAAH/MAGL-IN-3；化合物 FAAH/MAGL-IN-3FAAH/MAGL-IN-3

    FAAH/MAGL-IN-3 (Compound 10) is an irreversible dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) that acts on FAAH (IC50: 179 nM) and MAGL (IC50: 759 nM). FAAH/MAGL-IN-3 showed little PAMPA (parallel artificial membrane permeability assay) permeability.

    价 格：￥电议型 号：T62671产 地：中国大陆

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