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  • T80541TCMCB07 TFA；化合物 TCMCB07 TFATCMCB07 TFA

    TCMCB07 TFA is a cyclic nonapeptide and an orally active, brain-penetrating antagonist of the melanocortin receptor 4 (MC4R), playing a significant role in managing cachexia [1].

    价 格：￥电议型 号：T80541产 地：中国大陆

  • T80540TCMCB07；化合物 TCMCB07TCMCB07

    TCMCB07, a cyclic nonapeptide, serves as an orally active, brain-penetrant antagonist of the melanocortin receptor 4 (MC4R), with significant implications in the management of cachexia [1].

    价 格：￥电议型 号：T80540产 地：中国大陆

  • T78329Litifilimab；化合物 LitifilimabBIIB059；BIIB059

    Litifilimab, a humanized IgG1-κ antibody, targets the C-type lectin domain family 4 member C (CLEC4C) and has potential applications in the study of cutaneous lupus erythematosus (CLE) [1] [2].

    价 格：￥电议型 号：T78329产 地：中国大陆

  • T78296IMAB027；化合物 IMAB027ASP1650；ASP1650

    IMAB027 (ASP1650) is a specific monoclonal antibody targeting CLDN6 (Claudin 6), a membrane protein of tight junctions aberrantly overexpressed in multiple human cancers, notably in ovarian cancers. This compound exhibits anti-tumor properties and induces apoptosis specifically in CLDN6-positive ovarian and testicular cancer cell lines [1].

    价 格：￥电议型 号：T78296产 地：中国大陆

  • T77884PB038；化合物 PB038PB038

    PB038 is a drug-like molecule that incorporates a PEG (polyethylene glycol) unit and a cleavable linker conjugated to Exatecan [1].

    价 格：￥电议型 号：T77884产 地：中国大陆

  • T77416Opicinumab；奥匹努单抗BIIB033；BIIB033

    Opicinumab (BIIB033) is a novel monoclonal antibody against LINGO-1 that may be used to prevent and delay acute optic neuritis and recurrent multiple sclerosis.

    价 格：￥电议型 号：T77416产 地：中国大陆

  • T77042Aducanumab；阿杜那单抗BIIB037；BIIB037

    Aducanumab (BIIB037), A selective human immunoglobulin gamma-1 (IgG1) monoclonal antibody, targets the clustered form of amyloid beta (Aβ). Aducanumab shows brain permeability and may be used to treat Alzheimer´s disease (AD).

    价 格：￥电议型 号：T77042产 地：中国大陆

  • T76861Cinpanemab；辛帕奈单抗BIIB054；BIIB054

    Cinpanemab (BIIB054) is a novel human monoclonal antibody with affinity for alpha-synuclein residues 1-10. Cinpanemab can be used to study Parkinson´s disease and related diseases.

    价 格：￥电议型 号：T76861产 地：中国大陆

  • T74644DB0614；化合物 DB0614DB0614

    DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down a wide array of kinases including AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. This compound has potential applications in the research of diseases or disorders caused by aberrant kinase activity [1].

    价 格：￥电议型 号：T74644产 地：中国大陆

  • T73542DB008；化合物 DB008DB008

    DB008, a potent and selective PARP16 inhibitor, exhibits an IC50 value of 0.27 μM, incorporating an acrylamide electrophilic reagent. This membrane-permeable compound specifically targets PARP16.

    价 格：￥电议型 号：T73542产 地：中国大陆

  • T72023JB002；化合物JB002JB002

    JB002, a myosin II inhibitor, exhibits potent activity with an IC50 of ≤10 μM. It holds potential for research applications in muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy.

    价 格：￥电议型 号：T72023产 地：中国大陆

  • T71599AqB007；化合物 AqB007AqB007

    AqB007 is a selective blocker of the Aquaporin-1 ion channel conductance, thereby slowing cancer cell migration.

    价 格：￥电议型 号：T71599产 地：中国大陆

  • T71598AqB011；化合物 AqB011AqB011

    AqB011 is a selective blocker of the Aquaporin-1 ion channel conductance, slowing cancer cell migration.

    价 格：￥电议型 号：T71598产 地：中国大陆

  • T71585DB03417；化合物 DB03417DB03417

    DB03417 is a compound listed in web page: https://go.drugbank.com/drugs/DB03417. DB03417 is a potential tryptase inhibitor.

    价 格：￥电议型 号：T71585产 地：中国大陆

  • T71525AB05831；化合物 AB05831AB05831

    AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis of terminal, non-reducing N-acetyl-|3-D-glucosamine (GlcNAc) andN-acetyl-(3-D-galactosamine (GalNAc) residues in glycoproteins, gan-gliosides, and glycosaminoglycans (GAGs). HEX, released by chondrocytes into the extracellular compartment, promotes cartilage matrix degradation.

    价 格：￥电议型 号：T71525产 地：中国大陆

  • T71116MPT0B098；化合物 MPT0B098MPT0B098

    MPT0B098 is a potent microtubule inhibitor through binding to the colchicine-binding site of tubulin. MPT0B098 is active against the growth of various human cancer cells, including chemoresistant cells with IC50 values ranging from 70 to 150 nmol/L. MPT0B098 arrests cells in the G2?–M phase and subsequently induces cell apoptosis. In addition, MPT0B098 effectively suppresses VEGF-induced cell migration and capillary-like tube formation of HUVECs. Distinguished from other microtubule inhibitors,

    价 格：￥电议型 号：T71116产 地：中国大陆

  • T69937INCB059872 tosylate；化合物 INCB059872 tosylateINCB059872 tosylate

    INCB059872, also known as INCB59872, is a potent, selective, and orally active lysine-specific demethylase 1 inhibitor. INCB059872 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively, through amine oxidation. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. In addition, LSD

    价 格：￥电议型 号：T69937产 地：中国大陆

  • T69888SB02024；化合物 SB02024SB02024

    SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 and MCF-7, in vivo. Vps34 inhibitor significantly potentiated cytotoxicity of Sunitinib and Erlotinib in MCF-7 and MDA-MB-231 in vitro in monolayer cultures and when grown as multicellular spheroids. Our data suggests that inhibition of autophagy significantly improves sensitivity

    价 格：￥电议型 号：T69888产 地：中国大陆

  • T6949PLX7904化合物PLX7904PB04

    PLX7904 (PB04), also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.

    价 格：￥电议型 号：T6949产 地：中国大陆

  • T68383BIIB028；化合物 BIIB028BIIB028

    BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to o

    价 格：￥电议型 号：T68383产 地：中国大陆

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