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T1868JIB-04；化合物JIB04JIB 04|||NSC 693627；JIB 04|||NSC 693627|||5-氯-2(1H)-吡啶酮 (2E)-(苯基-2-吡啶基亚甲基)腙
JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor.
价 格：￥电议型 号：T1868产 地：中国大陆
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T1829Ruxolitinib芦可替尼芦可替尼|||INCB018424|||鲁索替尼|||(R)-Ruxolitinib
Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective. Rixolitinib exhibits antitumor activity and induces autophagy and apoptosis.
价 格：￥电议型 号：T1829产 地：中国大陆
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T18061KB02-SLF；化合物 T18061KB02-SLF
KB02-SLF is a PROTAC-based nuclear FKBP12 degrader, known as a molecular glue. It facilitates the degradation of nuclear FKBP12 by covalently modifying DCAF16, an E3 ligase. Moreover, KB02-SLF enhances the longevity of protein degradation in biological systems. The compound SLF acts as a linker, binding to the ubiquitin E3 ligase ligand KB02, resulting in the formation of KB02-SLF[1].
价 格：￥电议型 号：T18061产 地：中国大陆
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T18060KB02-JQ1；化合物 T18060KB02-JQ1
KB02-JQ1 is a potent and specific proteolysis targeting chimera (PROTAC) that specifically degrades BRD4, acting as a molecular glue. It does not degrade BRD2 or BRD3. The mechanism of action involves covalent modification of the E3 ligase DCAF16, thereby promoting BRD4 degradation. Importantly, KB02-JQ1 demonstrates enhanced stability and durability in facilitating protein degradation within biological systems. The compound forms a complex with the ubiquitin E3 ligase ligand KB02 through a link
价 格：￥电议型 号：T18060产 地：中国大陆
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T16275NB001；化合物NB001HTS 09836；HTS 09836
NB001 (HTS 09836) is an inhibitor of adenyl cyclase 1 exhibiting effects on neural and non-neural pain.
价 格：￥电议型 号：T16275产 地：中国大陆
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T16009LManaglinat dialanetil；地马格列MB06322|||MB 6322|||CS-917；MB06322|||MB 6322|||CS-917
Managlinat dialanetil (MB06322) is an orally available and potent fructose 1,6-bisphosphatase (FBPase) inhibitor with hypoglycaemic activity for the study of type 2 diabetes.
价 格：￥电议型 号：T16009L产 地：中国大陆
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T15056DB07107；化合物 T15056DB07107
DB07107 is a potent inhibitor of drug resistant T315I mutant Bcr-Abl tyrosine kinase and a potent Akt1 inhibitor (IC50: 360 nM).
价 格：￥电议型 号：T15056产 地：中国大陆
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T15055DB04760；化合物 DB04760MMP-13 Inhibitor；MMP-13 Inhibitor
DB04760 is a highly selective, non-zinc-chelating inhibitor of MMP-13 (IC50: 8 nM). DB04760 obviously decreases paclitaxel neurotoxicity and has anticancer activity.
价 格：￥电议型 号：T15055产 地：中国大陆
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T14491B022化合物 B022B022|||B-022
B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM), a chemical probe for the treatment of liver inflammation and injury.B022 protects the liver from inflammation and injury caused by oxidative stress and toxins.
价 格：￥电议型 号：T14491产 地：中国大陆
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T12477Uzansertib phosphate；化合物INCB053914 phosphateINCB053914 phosphate；INCB053914 phosphate
Uzansertib phosphate (INCB053914 phosphate) is an orally active, ATP-competitive inhibitor of pan-PIM kinase(PIM1, PIM2, PIM3 with IC50s of 0.24 nM, 30 nM, 0.12 nM , respectively).
价 格：￥电议型 号：T12477产 地：中国大陆
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T12401Pemigatinib；化合物PemigatinibINCB054828；INCB054828
Pemigatinib (INCB054828) is an orally active, selective inhibitor of FGFR(IC50s of 0.4 nM, 0.5 nM, 1.2 nM, 30 nM for FGFR1, FGFR2, FGFR3, FGFR4, respectively).
价 格：￥电议型 号：T12401产 地：中国大陆
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T12367Parsaclisib；化合物ParsaclisibINCB050465；INCB050465
Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)
价 格：￥电议型 号：T12367产 地：中国大陆
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T11649INCB054329 Racemate；化合物 T11649INCB054329 Racemate
INCB054329 Racemate is an inhibitor of BET protein.
价 格：￥电议型 号：T11649产 地：中国大陆
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T10704CCB02；化合物CCB02CCB02
CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity. CCB02 shows no inhibition on the cell cycle- and centrosome-related kinases, or the phosphorylation status of Aurora-A, CDK2, Plk1, Plk2, and CHK1.
价 格：￥电议型 号：T10704产 地：中国大陆
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T10692LNumidargistat；化合物 T10692LINCB01158|||CB-1158；INCB01158|||CB-1158
CB-1158 is a potent and orally bioavailable inhibitor of arginase (IC50s: 86 and 296 nM for recombinant human arginase 1 and 2).
价 格：￥电议型 号：T10692L产 地：中国大陆
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T10692CB-1158 dihydrochloride (2095732-06-0 free base)；化合物 T10692INCB01158 dihydrochloride|||CB-1158 dihyd
CB-1158 dihydrochloride is an effective and orally active inhibitor of arginase (IC50s: 86 nM and 296 nM for recombinant human arginase 1 and 2).
价 格：￥电议型 号：T10692产 地：中国大陆
