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  • T81184Sec61-IN-4；化合物 Sec61-IN-4Sec61-IN-4

    Sec61-IN-4 (Compound 16b) is a potent Sec61 inhibitor with an IC50 value of 0.04 nM in U87-MG cells [1].

    价 格：￥电议型 号：T81184产 地：中国大陆

  • T81183Sec61-IN-5；化合物 Sec61-IN-5Sec61-IN-5

    Sec61-IN-5 (Compound 16c), a Sec61 inhibitor, exhibits cytotoxicity in A549 cells with an IC50 of 0.27 nM and impedes Sec61-dependent secretory function with an IC50 of 0.08 nM [1].

    价 格：￥电议型 号：T81183产 地：中国大陆

  • T79771HDAC6-IN-22；化合物 HDAC6-IN-22HDAC6-IN-22

    HDAC6-IN-22 (compound 30), an HDAC6 inhibitor, exhibits an IC50 of 4.63 nM and demonstrates antiproliferative effects against multiple myeloma both in vitro and in vivo. It induces cell cycle arrest in the G2 phase and promotes apoptosis via the mitochondrial pathway [1].

    价 格：￥电议型 号：T79771产 地：中国大陆

  • T79769HDAC6-IN-23；化合物 HDAC6-IN-23HDAC6-IN-23

    HDAC6-IN-23 (compound 9), an orally active inhibitor of HDAC6 [1], displays selective enzymatic inhibition.

    价 格：￥电议型 号：T79769产 地：中国大陆

  • T79710PI3Kα/HDAC6-IN-1；化合物 PI3Kα/HDAC6-IN-1PI3Kα/HDAC6-IN-1

    PI3Kα/HDAC6-IN-1 (compound 21j) is a dual inhibitor of PI3Kα and HDAC6, exhibiting IC50 values of 2.9 nM and 26 nM, respectively. It effectively hinders AKT(Ser473) phosphorylation and promotes the build-up of acetylated α-tubulin, while not influencing acetylated histones H3 and H4. The compound demonstrates potent anti-cancer efficacy by inhibiting the L-363 cell line with an IC50 of 0.17 μM [1].

    价 格：￥电议型 号：T79710产 地：中国大陆

  • T79523HDAC6-IN-18；化合物 HDAC6-IN-18HDAC6-IN-18

    HDAC6-IN-18 (Compound 4), an irreversible and selective HDAC6 isoform inhibitor, exhibits potent anti-multiple myeloma effects. It demonstrates HDAC6 inhibitory activity with IC50 values of 0.17, 0.7, and 0.42 μM in RPMI8266, U266, and MM.1S cells, respectively [1].

    价 格：￥电议型 号：T79523产 地：中国大陆

  • T78839HDAC6-IN-19；化合物 HDAC6-IN-19HDAC6-IN-19

    HDAC6-IN-19 (Compound 14g), an HDAC6 inhibitor with an IC50 of 2.68 nM, additionally inhibits HDAC1, HDAC2, and HDAC3, with IC50 values of 61.6 nM, 98.7 nM, and 103 nM, respectively. This compound effectively suppresses the proliferation of various cancer cell lines, such as leukemia, colon cancer, melanoma, and breast cancer [1].

    价 格：￥电议型 号：T78839产 地：中国大陆

  • T78799BChE/HDAC6-IN-1；化合物 BChE/HDAC6-IN-1BChE/HDAC6-IN-1

    BChE/HDAC6-IN-1 is a dual BChE/HDAC6 inhibitor that exhibits potent and selective inhibition with IC50 values of 4 nM for BChE and 8.9 nM for HDAC6. It demonstrates efficacy in alleviating cognitive deficits in an Aβ1–42-induced mouse model, indicating its potential utility in Alzheimer´s disease research [1].

    价 格：￥电议型 号：T78799产 地：中国大陆

  • T78769HDAC6-IN-17；化合物 HDAC6-IN-17HDAC6-IN-17

    HDAC6-IN-17 (compound 5b) is a potent inhibitor of HDAC6, exhibiting IC50 values of 150 nM for HDAC6, 1400 nM for HDAC8, and 2300 nM for HDAC4. It demonstrates cytotoxic activity against human cancer cell lines and is utilized in cancer research [1].

    价 格：￥电议型 号：T78769产 地：中国大陆

  • T78768HDAC6-IN-16；化合物 HDAC6-IN-16HDAC6-IN-16

    HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colony formation, arresting the cell cycle at the G2 phase, and inducing apoptosis [1].

    价 格：￥电议型 号：T78768产 地：中国大陆

  • T78723ZINC61142882；化合物 ZINC61142882ZINC61142882

    ZINC61142882 is a SARS-CoV-2 Nsp14 N7-Methyltransferase inhibitor with an IC50 value of 6 μM [1].

    价 格：￥电议型 号：T78723产 地：中国大陆

  • T78462C6 NBD Glucosylceramide；化合物 C6 NBD GlucosylceramideC6 NBD Glucosylceramide

    C6 NBD Glucosylceramide, a fluorescent derivative of glucosylceramide (Ex=466 nm, Em=535 nm), is utilized to investigate glucosylceramide metabolism and internalization, as well as to assess glucosylceramide synthase activity [1] [2] [3].

    价 格：￥电议型 号：T78462产 地：中国大陆

  • T78461C6 NBD Ceramide；化合物 C6 NBD CeramideNbd-ceramide；Nbd-ceramide

    C6 NBD Ceramide is a cell-permeable Golgi fluorescent probe (Ex=466 nm, Em=536 nm), a neuraminidic acid with a green fluorescent tag that can recognize Golgi apparatus in live and fixed cells, observing morphological changes of the Golgi apparatus in live cells. C6 NBD Ceramide can be metabolized intracellularly to generate fluorescent sphingomyelin and glucosylceramide, thus applied in studies of sphingolipid transport and metabolism mechanisms.

    价 格：￥电议型 号：T78461产 地：中国大陆

  • T78191NH2-C6-ARC186；化合物 NH2-C6-ARC186NH2-C6-ARC186

    NH2-C6-ARC186 is a derivative of the aptamer ARC186, featuring an NH2-C6 moiety that enables coupling to various peptides or molecules. As a potent complement inhibitor, it operates by inhibiting convertase-mediated C5 activation [1].

    价 格：￥电议型 号：T78191产 地：中国大陆

  • T77953Thalidomide-5-O-C6-NH2 hydrochloride；化合物 Thalidomide-5-O-C6-NH2 hydrochlorideThalidomide-5-O-C6-NH2

    Thalidomide-5-O-C6-NH2 hydrochloride is a Thalidomide-based cereblon ligand that facilitates the recruitment of CRBN protein. This compound can be conjugated, via a linker, to another ligand to form proteolysis-targeting chimeras (PROTACs) [1].

    价 格：￥电议型 号：T77953产 地：中国大陆

  • T77922HDAC6 degrader-1；化合物 HDAC6 degrader-1HDAC6 degrader-1

    HDAC6 degrader-1, a proteolysis-targeting chimeric molecule (PROTAC), incorporates the selective HDAC6 inhibitor Nexturastat A (Nex A) for HDAC6 binding, a linker, and an E3 ligase recruiting ligand. This compound effectively induces HDAC6 degradation, displays superior selectivity over other HDAC isoforms, and efficiently inhibits cell proliferation [1].

    价 格：￥电议型 号：T77922产 地：中国大陆

  • T75167Homo-BacPROTAC6；化合物 Homo-BacPROTAC6Homo-BacPROTAC6

    Homo-BacPROTAC6, a ClpC1 NTD BacPROTAC degrader, effectively targets ClpC2, while Homo-BacPROTAC7 has been shown to efficiently kill M. tuberculosis [1].

    价 格：￥电议型 号：T75167产 地：中国大陆

  • T75017PROTAC HDAC6 degrader 1；化合物 PROTAC HDAC6 degrader 1PROTAC HDAC6 degrader 1

    Compound A6, a potent and selective PROTAC HDAC6 degrader, exhibits a DC50 of 3.5 nM. It demonstrates notable antiproliferative activity by inducing apoptosis in myeloid leukemia cell lines [1].

    价 格：￥电议型 号：T75017产 地：中国大陆

  • T74698RMC-6236；化合物 RMC-6236RMC6236；RMC6236

    RMC-6236 is a RAS(ON)MULTI inhibitor with anticancer activity and is used in the study of advanced malignant solid tumors and colorectal cancer.

    价 格：￥电议型 号：T74698产 地：中国大陆

  • T74617HDAC6-IN-8；化合物 HDAC6-IN-8HDAC6-IN-8

    Compound 12C, modified by altering cap groups, exhibits broad-spectrum enzyme inhibitory activity, as demonstrated in enzyme inhibition assays. Conversely, compounds 9m and 9q display a predilection towards HDAC6 inhibition, indicating subtype-selective inhibitory properties among the tested variants.

    价 格：￥电议型 号：T74617产 地：中国大陆

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