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  • T79095SB-649701；化合物 SB-649701SB-649701

    SB-649701 is a potent antagonist of the human CCR8 receptor, exhibiting a pIC50 value of 7.7, and is utilized in asthma research [1].

    价 格：￥电议型 号：T79095产 地：中国大陆

  • T7904SR 19881；化合物SR 19881SR 19881

    SR 19881 is a full agonist of ERRγ(EC50 value of 0.39 μM in a binding assay and an EC50 value of 4.7 μM in a cell-based assay).

    价 格：￥电议型 号：T7904产 地：中国大陆

  • T78765SARS-CoV-2-IN-51；化合物 SARS-CoV-2-IN-51SARS-CoV-2-IN-51

    SARS-CoV-2-IN-51 (S-10), a lead compound for Omicron fusion inhibition, demonstrates potent activity against Omicron and other SARS-CoV-2 variants, with EC50 values ranging from 0.82-5.45 μM. It functions by directly interacting with the spike (S) protein in the prefusion state [1], thereby preventing viral entry.

    价 格：￥电议型 号：T78765产 地：中国大陆

  • T78762SIKs-IN-1；化合物 SIKs-IN-1SIKs-IN-1

    SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, functions as an inhibitor of Salt-inducible kinases (SIKs), which play a role in the M1/M2 macrophage polarization linked to inflammation. By inhibiting SIK activity, this compound increases the anti-inflammatory cytokine IL-10 and decreases the pro-inflammatory cytokine IL-12, demonstrating significant anti-inflammatory efficacy in a DSS-induced colitis model [1].

    价 格：￥电议型 号：T78762产 地：中国大陆

  • T78721Smurf1-IN-1；化合物 Smurf1-IN-1Smurf1-IN-1

    Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy in a rat model of pulmonary hypertension [1].

    价 格：￥电议型 号：T78721产 地：中国大陆

  • T78682SJ1461；化合物 SJ1461SJ1461

    SJ1461 is a potent, orally active inhibitor of the BET family, selectively targeting and inhibiting BRD2 (BD1), BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) with respective IC50 values of 1.6 nM, 0.1 nM, 6.5 nM, and 0.2 nM [1].

    价 格：￥电议型 号：T78682产 地：中国大陆

  • T78196SIK2-IN-1；化合物 SIK2-IN-1SIK2-IN-1

    SIK2-IN-1 (compound 8g) is a potent inhibitor of SIK2 with selectivity over other AMPK-family kinases, demonstrating favorable ADMET profiles in vitro and robust cellular activities [1].

    价 格：￥电议型 号：T78196产 地：中国大陆

  • T78174Serine Hydrolase inhibitor-21；化合物 Serine Hydrolase inhibitor-21Serine Hydrolase inhibitor-21

    Serine Hydrolase Inhibitor-21 (compound 8), a pyridine-based serine hydrolase inhibitor, exhibits a K i of 429 nM against BuChE, and shows promise for Alzheimer´s disease research [1].

    价 格：￥电议型 号：T78174产 地：中国大陆

  • T78165SPEN inhibitor 1；化合物 SPEN inhibitor 1SPEN inhibitor 1

    SPEN-IN-1 (compound X1) is a selective inhibitor of the SPEN protein factor, exhibiting a dissociation constant (K d) of 47 nM. Notably, it exhibits high specificity for RepA, a 431-nucleotide domain within Xist (a non-coding RNA prototype), characterized by 8.5 repeats of a GC-rich motif instrumental in gene silencing [1].

    价 格：￥电议型 号：T78165产 地：中国大陆

  • T76374SPAI-1；化合物 SPAI-1SPAI-1

    SPAI-1, a peptide isolated from porcine duodenum, serves as a specific inhibitor to monovalent cation transporting ATPases, effectively inhibiting Na+, K+-ATPase and H+, K+-ATPase while stimulating Mg2+-ATPase in vitro [1] [2].

    价 格：￥电议型 号：T76374产 地：中国大陆

  • T75161STING agonist-31；化合物 STING agonist-31STING agonist-31

    STING agonist-31, a potent STING agonist, exhibits EC50 values of 0.24 μM and 39.51 μM for human STING (h-STING) and murine STING (m-STING), respectively, demonstrating significant antitumor efficacy [1].

    价 格：￥电议型 号：T75161产 地：中国大陆

  • T74894SIRT1/2/3-IN-1；化合物 SIRT1/2/3-IN-1SIRT1/2/3-IN-1

    SIRT1/2/3-IN-1 (compound 10) is a potent, selective, and cell-permeable inhibitor targeting SIRT1, SIRT2, and SIRT3, demonstrating inhibitory concentrations (IC50s) of 0.54 μM, 0.253 μM, and 0.72 μM, respectively. It is utilized in cancer research [1].

    价 格：￥电议型 号：T74894产 地：中国大陆

  • T74859SLC7A11-IN-1；化合物 SLC7A11-IN-1SLC7A11-IN-1

    SLC7A11-IN-1 is a potent inhibitor of the solute carrier family 7 member 11 (SLC7A11, xCT), exhibiting antiproliferative, anti-tumor activities, and the ability to inhibit cell invasion and metastasis. It induces apoptosis and arrests cell cycle progression in the S-phase [1].

    价 格：￥电议型 号：T74859产 地：中国大陆

  • T74822S1R agonist 1；化合物 S1R agonist 1S1R agonist 1

    Compound 6b, also known as S1R agonist 1, is a selective agonist for S1R with dissociation constants (Ki) of 0.93 nM for S1R and 72 nM for S2R. This compound demonstrates neuroprotective effects against reactive oxygen species (ROS) and NMDA-induced neurotoxicity [1].

    价 格：￥电议型 号：T74822产 地：中国大陆

  • T74816Complement C1s-IN-1；化合物 Complement C1s-IN-1Complement C1s-IN-1

    Complement C1s-IN-1 is a potent and selective C1s inhibitor that is orally active and capable of crossing the blood-brain barrier, demonstrating an IC50 value of 36 nM [1].

    价 格：￥电议型 号：T74816产 地：中国大陆

  • T74730SPC4061；化合物 SPC4061SPC4061

    SPC4061, a potent PCSK9 inhibitor and an antisense nucleotide, specifically targets the lock-in nucleic acid (LNA) of PCSK9. This action is relevant for researching hypercholesterolemia and associated diseases [1] [2].

    价 格：￥电议型 号：T74730产 地：中国大陆

  • T74545STAT3 degrader-1；化合物 STAT3 degrader-1STAT3 degrader-1

    STAT3 Degrader-1 (Compound 295) is a potent degrader of STAT3, utilized in anticancer research [1].

    价 格：￥电议型 号：T74545产 地：中国大陆

  • T74462SNIPER(TACC3)-11；化合物 SNIPER(TACC3)-11SNIPER(TACC3)-11

    SNIPER(TACC3)-11 is a potent degrader of the FGFR3-TACC3 protein, effectively diminishing its levels and inhibiting the proliferation of cancer cells positive for FGFR3-TACC3 [1].

    价 格：￥电议型 号：T74462产 地：中国大陆

  • T7361Verucerfont；化合物VerucerfontNBI77860|||GSK561679；NBI77860|||3-(4-甲氧基-2-甲基苯基)-2,5-二甲基-N-[(1S)-1-(3-甲基-1

    Verucerfont (NBI77860) is an antagonist of corticotropin-releasing factor receptor 1 (CRF1) .

    价 格：￥电议型 号：T7361产 地：中国大陆

  • T73555SPR41；化合物 SPR41SPR41

    SPR41, a potent inhibitor of the SARS-CoV-2 main protease (Mpro), exhibits Ki values of 0.184 ?M for SARS-CoV-2 Mpro, 0.252 ?M for hCatL, and 14.4 ?M for hCatB, demonstrating significant antiviral activity and cytotoxicity.

    价 格：￥电议型 号：T73555产 地：中国大陆

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