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T35880Renin Fluorogenic Substrate；Renin Fluorogenic SubstrateRenin Fluorogenic Substrate
The renin fluorogenic substrate consists of the normal peptide substrate for renin which has been linked to the fluorophore EDANS at one end and to a non-fluorescent quenching molecule (Dabcyl) at the other. After cleavage by renin, the product (peptide-EDANS) is brightly fluorescent and can be easily analyzed using an excitation wavelength of 340 nm and emission wavelengths of 485-510 nm.
价 格：￥电议型 号：T35880产 地：中国大陆
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T3588JK184；化合物JK184JK184
JK184 is a potent Hedgehog (Hh) pathway inhibitor.
价 格：￥电议型 号：T3588产 地：中国大陆
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T35879Octyl glucose neopentyl glycol；Octyl glucose neopentyl glycolOctyl glucose neopentyl glycol
Octyl glucose neopentyl glycol (OGNG) is a detergent derived from neopentyl glycol, intended for stabilizing membrane proteins [1].
价 格：￥电议型 号：T35879产 地：中国大陆
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T35878N-(3-Aminopropyl)cyclohexylamine；N-(3-氨丙基)环己胺N-(3-Aminopropyl)cyclohexylamine
N-(3-Aminopropyl)cyclohexylamine, a derivative of cyclohexylamine, functions as a selective and competitive inhibitor of spermine synthase, making it suitable for research on neurological diseases[1].
价 格：￥电议型 号：T35878产 地：中国大陆
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T35877MurA-IN-1；MurA-IN-1MurA-IN-1
MurA-IN-1 (compound 1a), a PTPRR inhibitor, exhibits IC50 values of 0.09 μM for PTPRR, 0.23 μM for PTP1B, 0.75 μM for PTPN7, and 0.8 μM for PTPN5, respectively, targeting a family of human MAPK-specific protein tyrosine phosphatases[1].
价 格：￥电议型 号：T35877产 地：中国大陆
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T35876Chlorthalidone Impurity G；Chlorthalidone Impurity GChlorthalidone Impurity G
Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) an
价 格：￥电议型 号：T35876产 地：中国大陆
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T35875CCG258208 hydrochloride；CCG258208 hydrochlorideCCG258208 hydrochloride
GRKs-IN-1 hydrochloride, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=130 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 hydrochloride is a derivative 14as of paroxetine, shows a 100-fold improvement in cardiomyocyte contractility assays over paroxetine[1].
价 格：￥电议型 号：T35875产 地：中国大陆
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T35874CC260；CC260CC260
CC260, a selective inhibitor for PI5P4Kα and PI5P4Kβ with Kis of 40 nM and 30 nM respectively, exhibits minimal to no inhibition against other protein kinases like Plk1 and RSK2. It is applicable in the research of cell energy metabolism, diabetes, and cancer[1].
价 格：￥电议型 号：T35874产 地：中国大陆
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T35873C19 Ceramide (d18:1/19:0)；C19 Ceramide (d18:1/19:0)C19 Ceramide (d18:1/19:0)；C19 Ceramide (d18:1/19:
C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3]
价 格：￥电议型 号：T35873产 地：中国大陆
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T35872BRD-8000.3；BRD-8000.3BRD-8000.3
BRD-8000.3 is a narrow-spectrum, bactericidal antimycobacterial agent known for its specific inhibition of EfpA. It exhibits potent activity against wild-type strains and proves to be a valuable tool in tuberculosis research[1].
价 格：￥电议型 号：T35872产 地：中国大陆
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T35870Boc-D-His-OH；Boc-D-His-OHBoc-D-His-OH
Boc-D-His-OH is an amino acid derivative and has a wide range of applications in life science related research.
价 格：￥电议型 号：T35870产 地：中国大陆
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T3587NOD-IN-1；化合物NOD-IN-1Compound 4；Compound 4
NOD-IN-1 (Compound 4) is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors.
价 格：￥电议型 号：T3587产 地：中国大陆
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T35869Berotralstat；BerotralstatBerotralstat
Berotralstat (BCX7353) is a second-generation, synthetic, and orally active plasma kallikrein inhibitor with low toxicity. It is highly specific and effectively used in the research of hereditary angioedema (HAE) attacks. Berotralstat functions by inhibiting the enzymatic activity of plasma kallikrein, which is responsible for the release of bradykinin. This blocking mechanism targets the major biologic peptide involved in the promotion of swelling and pain associated with HAE attacks[1][2].
价 格：￥电议型 号：T35869产 地：中国大陆
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T35868BCAT-IN-2；BCAT 抑制剂2BCAT-IN-2
BCAT-IN-2 is an orally active and selective inhibitor of mitochondrial branched-chain aminotransferase (BCATm), inhibits BCATm and BCATc, and is used in obesity and dyslipidemia.
价 格：￥电议型 号：T35868产 地：中国大陆
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T35867TRAP-6 Peptide (trifluoroacetate salt)；TRAP-6 Peptide (trifluoroacetate salt)TRAP-6 Peptide (trifluo
TRAP-6 peptide is a hexapeptide corresponding to residues 42-47 of protease-activated receptor 1 (PAR1). It acts as an agonist of PAR1, inducing platelet aggregation in human platelet-rich plasma ex vivo (EC50 = 0.8 μM). TRAP-6 (0.3 and 0.6 mg/kg) has a triphasic effect on mean arterial blood pressure (MAP) in anesthetized rats with a short decrease, an increase, and then a longer decrease in MAP following intravenous administration.
价 格：￥电议型 号：T35867产 地：中国大陆
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T35864T-5342126T-5342126T 5342126|||T5342126
T-5342126 is a toll-like receptor 4 (TLR4) antagonist.1It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC50= 27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC50s = 110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-depen
价 格：￥电议型 号：T35864产 地：中国大陆
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T35863VRK-IN-1VRK 抑制剂1VRK IN 1|||VRKIN1
VRK-IN-1 is a potent and selective inhibitor of cowpox-associated kinase 1 (VRK1), which can be used in the study of neurological disorders.
价 格：￥电议型 号：T35863产 地：中国大陆
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T35862Cucurbit[8]uril；葫芦[8]脲Cucurbit[8]uril
Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications.
价 格：￥电议型 号：T35862产 地：中国大陆
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T35861COQ7-IN-1COQ7-IN-1COQ7-IN-1
COQ7-IN-1 is a powerful inhibitor of human coenzyme Q (COQ7), effectively disrupting the synthesis of ubiquinone (UQ) in the body. Notably, COQ7-IN-1 does not disrupt the natural growth of human normal culture cells. This compound proves valuable for investigating the equilibrium between two pathways of UQ supplementation: de novo UQ synthesis and extracellular UQ uptake[1].
价 格：￥电议型 号：T35861产 地：中国大陆
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T35860AP39；AP39AP39|||AP 39|||AP-39|||AP-39|||AP39；AP39|||AP 39|||AP-39|||AP-39|||AP39
AP39 is a compound used to increase the levels of hydrogen sulfide (H2S) within mitochondria. It consists of a mitochondria-targeting motif (triphenylphosphonium) coupled to an H2S-donating moiety (dithiolethione) by an aliphatic linker. AP39 (30-300 nM) dose-dependently increases H2S levels in endothelial cells, predominantly in mitochondrial regions. It stimulates mitochondrial electron transport and improves cellular bioenergetic function at lower concentrations (30-100 nM), while having an i
价 格：￥电议型 号：T35860产 地：中国大陆
